Issue 43, 2020

Simultaneous and visual detection of cysteamine based on Michael addition reaction with polydiacetylene liposomes

Abstract

In this study, we report the fabrication of a highly sensitive colorimetric and fluorometric sensor comprising self-assembled polydiacetylene (PDA) liposomes for the measurement of cysteamine concentration. The N-maleimidomethanol (HM) moiety was used as the Michael addition acceptor, which reacts with the thiol groups in cysteamine to generate maleimide–thiol conjugation resulting in the conformational transition of the conjugated backbone. Furthermore, this chemosensor system displays a clear blue-to-red colorimetric transition in the presence of cysteamine among various biothiols with high selectivity and sensitivity owing to the structural specificity of cysteamine. The resulting PDA solutions were analyzed via FE-SEM, UV-vis, fluorescence and Raman spectroscopy, and chromoisomerism for naked-eye visualization. This chemosensor provides a convenient method for the detection of cysteamine in aqueous solution and in real samples.

Graphical abstract: Simultaneous and visual detection of cysteamine based on Michael addition reaction with polydiacetylene liposomes

Supplementary files

Article information

Article type
Paper
Submitted
08 มิ.ย. 2563
Accepted
03 ส.ค. 2563
First published
04 ส.ค. 2563

J. Mater. Chem. C, 2020,8, 15290-15295

Simultaneous and visual detection of cysteamine based on Michael addition reaction with polydiacetylene liposomes

T. C. Pham, S. Lee, Y. R. Son, M. Kwak, H. S. Kim and S. Lee, J. Mater. Chem. C, 2020, 8, 15290 DOI: 10.1039/D0TC02721A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements