Issue 15, 2020

A natural polymer based bioadhesive with self-healing behavior and improved antibacterial properties

Abstract

Bioadhesives are of great interest for tissue/wound closure to reduce surgical time, minimize treatment invasiveness, and prevent body fluid leakage. However, bacterial infections remain a major concern during wound healing and tissue bonding. Hence, the development of bioadhesives with antibacterial properties is necessary. In this study, a hydrogel bioadhesive based on silk fibroin (SF) and tannic acid (TA) was combined with silver nanoparticles (AgNPs) generated in situ during hydrogel formation to improve its antibacterial abilities. In this system, TA can be regarded as a phenolic glue molecule to spontaneously co-assemble with SF to fabricate the adhesive matrix network and also as a reductant to induce silver nitrate to form AgNPs evenly within the adhesive network. Furthermore, the influence of the amount of silver nitrate was considered. The produced hybrid hydrogel bioadhesives with different amounts of AgNPs exhibited self-healing capabilities, considerable wet tissue adhesion strengths (14.32 ± 1.85 kPa–28.80 ± 2.29 kPa) and good cytocompatibility. When the initial concentration of silver nitrate was more than 0.05 wt%, the produced STA bioadhesive showed effective antibacterial properties in vitro. These results demonstrate that these STA bioadhesives have the potential to be used in tissue/wound closure, especially when bacterial infections are a main problem.

Graphical abstract: A natural polymer based bioadhesive with self-healing behavior and improved antibacterial properties

Supplementary files

Article information

Article type
Paper
Submitted
19 เม.ย. 2563
Accepted
04 มิ.ย. 2563
First published
19 มิ.ย. 2563

Biomater. Sci., 2020,8, 4346-4357

A natural polymer based bioadhesive with self-healing behavior and improved antibacterial properties

X. Ke, Z. Dong, S. Tang, W. Chu, X. Zheng, L. Zhen, X. Chen, C. Ding, J. Luo and J. Li, Biomater. Sci., 2020, 8, 4346 DOI: 10.1039/D0BM00624F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements