Issue 12, 2018

Mechanisms of and variables affecting UVR photoadaptation in human skin

Abstract

Humans have been exposed to solar UV radiation since their appearance on Earth and evolution has enabled most individuals to adapt to this exposure, to some degree. UV radiation produces several deleterious effects in human skin and light-skinned individuals are at greatest risk for both acute and long-term negative effects such as DNA damage, sunburn, immune suppression and skin cancer. The benefits of photoadaptation, which leads to a decreased response after acclimatization, are that humans who have skin that is capable of photoadaptation can work and play in the sun with reduced fear of painful sunburn. However, the effects of photoadaptation on DNA damage and development of skin cancer are quite complex and less well-understood. In this article, we have reviewed the current state of knowledge of UVR photoadaptation in human skin. However, more studies are needed to explore the use of UVR photoadaptation to protect against critical endpoints, such as skin cancer.

Graphical abstract: Mechanisms of and variables affecting UVR photoadaptation in human skin

Article information

Article type
Paper
Submitted
21 พ.ย. 2560
Accepted
04 พ.ค. 2561
First published
31 พ.ค. 2561

Photochem. Photobiol. Sci., 2018,17, 1932-1940

Mechanisms of and variables affecting UVR photoadaptation in human skin

M. Garmyn, A. R. Young and S. A. Miller, Photochem. Photobiol. Sci., 2018, 17, 1932 DOI: 10.1039/C7PP00430C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements