Issue 75, 2022

Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Abstract

Naphthalimide-based fluorescent probes (NAN0-N3 and NAN6-N3) were developed with dual locked fluorescence. Here, ≥1.9 × 10−2 mM of H2S and ≥2.2 × 10−2 μg mL−1 of DNA could unlock a highly sensitive off–on fluorescence response through synergistic changes of the molecular structure and conformation. As such, the probes could monitor DNA damage induced by the overexpression of H2S, and were able to evaluate the degree of apoptosis of living cells mediated by H2S-induced mtDNA or nDNA damage.

Graphical abstract: Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Supplementary files

Article information

Article type
Communication
Submitted
29 ก.ค. 2565
Accepted
23 ส.ค. 2565
First published
31 ส.ค. 2565

Chem. Commun., 2022,58, 10500-10503

Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Y. Wang, X. Zhao, Y. Chen, T. D. James, G. Wang and H. Zhang, Chem. Commun., 2022, 58, 10500 DOI: 10.1039/D2CC04247A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements