Multi-component heteroarene couplings via polarity-reversed radical cascades

Jeremy M. Lear; J. Quentin Buquoi; Xin Gu; Kui Pan; Darsheed N. Mustafa; David A. Nagib

doi:10.1039/C9CC03498F

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Multi-component heteroarene couplings via polarity-reversed radical cascades†

Jeremy M. Lear,‡^a J. Quentin Buquoi,‡^a Xin Gu,^a Kui Pan,^a Darsheed N. Mustafa^a and David A. Nagib

*^a

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* Corresponding authors

^a Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA
E-mail: nagib.1@osu.edu

Abstract

A multi-component radical addition strategy enables difunctionalization of alkenes with heteroarenes and a variety of radical precursors, including N₃, P(O)R₂, and CF₃. This unified approach for coupling diverse classes of electrophilic radicals and heteroarenes to vinyl ethers allows for direct, vicinal C–C as well as C–N, C–P, and C–R_f bond formation.

This article is part of the themed collection: 2019 Emerging Investigators

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DOI: https://doi.org/10.1039/C9CC03498F
Article type: Communication
Submitted: 07 พ.ค. 2562
Accepted: 21 พ.ค. 2562
First published: 21 พ.ค. 2562

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Chem. Commun., 2019,55, 8820-8823

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Multi-component heteroarene couplings via polarity-reversed radical cascades

J. M. Lear, J. Q. Buquoi, X. Gu, K. Pan, D. N. Mustafa and D. A. Nagib, Chem. Commun., 2019, 55, 8820 DOI: 10.1039/C9CC03498F

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Chemical Communications

Multi-component heteroarene couplings via polarity-reversed radical cascades†

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Multi-component heteroarene couplings via polarity-reversed radical cascades

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