A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

Rahul T. Kadakia; Da Xie; Daniel Martinez; Meng Yu; Emily L. Que

doi:10.1039/C9CC00375D

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A dual-responsive probe for detecting cellular hypoxia using ¹⁹F magnetic resonance and fluorescence†

Rahul T. Kadakia,

^a Da Xie,

^a Daniel Martinez, Jr,

^a Meng Yu

^a and Emily L. Que

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Texas at Austin, 105 E 24th St. Stop A5300, Austin, TX, USA
E-mail: emilyque@cm.utexas.edu

Abstract

We report the first dual-responsive ¹⁹F MRI and fluorescence imaging probe for cellular hypoxia. The Cu²⁺-based probe exhibits no ¹⁹F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu⁺. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

This article is part of the themed collection: 2019 Emerging Investigators

Download options Please wait...

Supplementary files

Supplementary information PDF (1573K)

Article information

DOI: https://doi.org/10.1039/C9CC00375D
Article type: Communication
Submitted: 15 ม.ค. 2562
Accepted: 13 มิ.ย. 2562
First published: 13 มิ.ย. 2562

Download Citation

Chem. Commun., 2019,55, 8860-8863

Permissions

Request permissions

A dual-responsive probe for detecting cellular hypoxia using ¹⁹F magnetic resonance and fluorescence

R. T. Kadakia, D. Xie, D. Martinez, M. Yu and E. L. Que, Chem. Commun., 2019, 55, 8860 DOI: 10.1039/C9CC00375D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications