Issue 1, 2017

Electrically controlled release of insulin using polypyrrole nanoparticles

Abstract

Conducting polymers present an opportunity for developing programmable, adjustable, spatially, and temporally controllable drug delivery systems. While several small molecule drugs have been released from thin conductive polymeric films successfully, delivering large molecule therapeutics, such as polypeptides and nucleic acids, has remained a significant challenge. Poor drug loading (∼ng cm−2) of thin films coupled with film instability has, in many cases, made conducting polymer films refractory to clinical development. To address these limitations, we have utilized conductive polymer nanoparticulate backbones to controllably release insulin, a high molecular weight, clinically relevant polypeptide. We find that the interaction between insulin and the polymer scaffold can be described by a simple Langmuir-type adsorption model. By modifying the ratio of the amount of nanoparticles to the amount of insulin, we have obtained drug loading percentages estimated to be as high as 51 wt% percent. In vivo experiments in mice confirmed retained bioactivity of the released insulin after electrical stimulation.

Graphical abstract: Electrically controlled release of insulin using polypyrrole nanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
22 ต.ค. 2559
Accepted
02 ธ.ค. 2559
First published
02 ธ.ค. 2559

Nanoscale, 2017,9, 143-149

Electrically controlled release of insulin using polypyrrole nanoparticles

N. Hosseini-Nassab, D. Samanta, Y. Abdolazimi, J. P. Annes and R. N. Zare, Nanoscale, 2017, 9, 143 DOI: 10.1039/C6NR08288B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements