Issue 25, 2014

Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye

Abstract

Elevated levels of homocysteine (Hcy) in blood are indicative of many high risk cardiovascular and neurodegenerative diseases. Thus, development of highly efficient and selective dyes for monitoring Hcy levels has attracted much attention. This paper reports the utilization of TPE-Cy, an aggregation-induced-emission active hemicyanine dye, as a probe for the detection of Hcy. More interestingly, this dye shows high selectivity to Hcy over cysteine, glutathione and other amino acids in weakly basic buffer solution.

Graphical abstract: Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye

Supplementary files

Article information

Article type
Paper
Submitted
08 เม.ย. 2557
Accepted
29 เม.ย. 2557
First published
29 เม.ย. 2557

J. Mater. Chem. B, 2014,2, 3919-3923

Author version available

Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye

S. Chen, Y. Hong, J. Liu, N. Tseng, Y. Liu, E. Zhao, J. W. Yip Lam and B. Z. Tang, J. Mater. Chem. B, 2014, 2, 3919 DOI: 10.1039/C4TB00551A

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