Issue 4, 2010

Cross-couplings between benzylic and aryl halides “on water”: synthesis of diarylmethanes

Abstract

A remarkably simple entry to unsymmetrical diarylmethanes has been developed that relies on an in situ organozinc-mediated, palladium-catalyzed cross-coupling. Thus, by mixing a benzyl and aryl halide together in the presence of Zn metal and a Pd catalyst, diarylmethanes are formed at room temperature without assistance by a surfactant; hence, “on water”.

Graphical abstract: Cross-couplings between benzylic and aryl halides “on water”: synthesis of diarylmethanes

Supplementary files

Article information

Article type
Communication
Submitted
26 ต.ค. 2552
Accepted
30 พ.ย. 2552
First published
09 ธ.ค. 2552

Chem. Commun., 2010,46, 562-564

Cross-couplings between benzylic and aryl halides “on water”: synthesis of diarylmethanes

C. Duplais, A. Krasovskiy, A. Wattenberg and B. H. Lipshutz, Chem. Commun., 2010, 46, 562 DOI: 10.1039/B922280D

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