Issue 9, 2024

Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms

Abstract

Gene therapy is a revolutionary treatment approach in the 21st century, offering significant potential for disease prevention and treatment. However, the efficacy of gene delivery is often compromised by the inherent challenges of gene properties and vector-related defects. It is crucial to explore ways to enhance the curative effect of gene drugs and achieve safer, more widespread, and more efficient utilization, which represents a significant challenge in amplification gene therapy advancements. Spherical nucleic acids (SNAs), with their unique physicochemical properties, are considered an innovative solution for scalable gene therapy. This review aims to comprehensively explore the amplifying contributions of SNAs in gene therapy and emphasize the contribution of SNAs to the amplification effect of gene therapy from the aspects of structure, application, and recent clinical translation – an aspect that has been rarely reported or explored thus far. We begin by elucidating the fundamental characteristics and scaling-up properties of SNAs that distinguish them from traditional linear nucleic acids, followed by an analysis of combined therapy treatment strategies, theranostics, and clinical translation amplified by SNAs. We conclude by discussing the challenges of SNAs and provide a prospect on the amplification characteristics. This review seeks to update the current understanding of the use of SNAs in gene therapy amplification and promote further research into their clinical translation and amplification of gene therapy.

Graphical abstract: Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms

Article information

Article type
Review Article
Submitted
24 พ.ย. 2566
Accepted
11 ม.ค. 2567
First published
11 ม.ค. 2567

Nanoscale, 2024,16, 4392-4406

Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms

Z. Tao, H. Zhang, S. Wu, J. Zhang, Y. Cheng, L. Lei, Y. Qin, H. Wei and C. Yu, Nanoscale, 2024, 16, 4392 DOI: 10.1039/D3NR05971E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements