Issue 30, 2023

Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

Abstract

A heavy-atom-free photosensitizer (CI) based on an imidazole–carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.

Graphical abstract: Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

Supplementary files

Article information

Article type
Communication
Submitted
08 ม.ค. 2566
Accepted
20 มี.ค. 2566
First published
20 มี.ค. 2566

Chem. Commun., 2023,59, 4503-4506

Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

T. C. Pham, D. J. Lee, D. H. Kim, J. Yoon, T. D. Lam, H. M. Kim and S. Lee, Chem. Commun., 2023, 59, 4503 DOI: 10.1039/D3CC00108C

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