Issue 31, 2021

Hyaluronic acid-based hydrogels to study cancer cell behaviors

Abstract

Hyaluronic acid (HA) is a natural polysaccharide and a key component of the extracellular matrix (ECM) in many tissues. Therefore, HA-based biomaterials are extensively utilized to create three dimensional ECM mimics to study cell behaviors in vitro. Specifically, derivatives of HA have been commonly used to fabricate hydrogels with controllable properties. In this review, we discuss the various chemistries employed to fabricate HA-based hydrogels as a tunable matrix to mimic the cancer microenvironment and subsequently study cancer cell behaviors in vitro. These include Michael-addition reactions, photo-crosslinking, carbodiimide chemistry, and Diels–Alder chemistry. The utility of these HA-based hydrogels to examine cancer cell behaviors such as proliferation, migration, and invasion in vitro in various types of cancer are highlighted. Overall, such hydrogels provide a biomimetic material-based platform to probe cell-matrix interactions in cancer cells in vitro and study the mechanisms associated with cancer progression.

Graphical abstract: Hyaluronic acid-based hydrogels to study cancer cell behaviors

Article information

Article type
Review Article
Submitted
28 เม.ย. 2564
Accepted
07 ก.ค. 2564
First published
07 ก.ค. 2564

J. Mater. Chem. B, 2021,9, 6103-6115

Author version available

Hyaluronic acid-based hydrogels to study cancer cell behaviors

K. Goodarzi and S. S. Rao, J. Mater. Chem. B, 2021, 9, 6103 DOI: 10.1039/D1TB00963J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements