Issue 27, 2021

Hydrophilic and anti-adhesive modification of porous polymer microneedles for rapid dermal interstitial fluid extraction

Abstract

Porous polymer microneedles (MNs) with interconnected structures demonstrate great potential in dermal interstitial fluid (ISF) extraction. However, the fluid extraction rate and the recovery of the extracted ISF by the porous MNs are limited by the poor hydrophilicity and the adhesion of porous MNs. Herein, we present a facile and mild polydopamine (PDA) and poly(ethylene glycol) (PEG) coating strategy for hydrophilic and anti-adhesive modification of porous polymer MNs from a phase inversion method. As a proof-of-concept, taking polysulfone (PSF) as an example, PDA and PEG-coated MNs (PSF@PDA@PEG) are fabricated through the self-polymerization of dopamine and PEG anchoring. Thanks to the hydrophilicity and anti-adhesion of PEG, the resulting PSF@PDA@PEG MNs demonstrate improved hydrophilicity, fast fluid extraction speed, and low target molecular adhesion. Besides, this method can be extended to hydrophobic polymers generally used in medical fields, including polylactic acid (PLA), polyvinylidene fluoride (PVDF), etc. This investigation provides a new road for MN-based off-line analysis in point-of-care testing (POCT).

Graphical abstract: Hydrophilic and anti-adhesive modification of porous polymer microneedles for rapid dermal interstitial fluid extraction

Supplementary files

Article information

Article type
Paper
Submitted
19 เม.ย. 2564
Accepted
04 มิ.ย. 2564
First published
04 มิ.ย. 2564

J. Mater. Chem. B, 2021,9, 5476-5483

Hydrophilic and anti-adhesive modification of porous polymer microneedles for rapid dermal interstitial fluid extraction

P. Liu, H. Du, Z. Wu, H. Wang, J. Tao, L. Zhang and J. Zhu, J. Mater. Chem. B, 2021, 9, 5476 DOI: 10.1039/D1TB00873K

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