A novel aptameric nanobiosensor based on the self-assembled DNA–MoS2 nanosheet architecture for biomolecule detection

Abstract

We have developed a novel fluorescence-activated DNA–MoS₂ nanosheet biosensor for detecting biomolecular targets such as proteins and small molecules based on the self-assembled architecture of a DNA aptamer and a MoS₂ nanosheet. The proposed design is simple to prepare and exhibits low background interference, high sensitivity and rapid response.