Themed collection Recent Review Articles

Functionalization of rod-shaped plant viruses for biomedical applications
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05354K

Hydrogen Bubble Evolution and Its Induced Mass Transfer on Zinc Electrodes in Alkaline and Neutral Media
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR05108D

Characterisation of polymeric nanoparticles for drug delivery
Polymeric nanoparticles represent an innovative approach to drug delivery, particularly for addressing complex diseases like cancer.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00071H
Multifunctional DNA nanomaterials: a new frontier in rheumatoid arthritis diagnosis and treatment
DNA nanomaterials offer promising advancements in addressing the challenges of rheumatoid arthritis (RA) through targeted drug delivery, biomarker detection, and therapeutic innovation.
Nanoscale, 2025,17, 4974-4999
https://doi.org/10.1039/D4NR04013A
External strategies for enhanced sensing performance of self-powered polyvinylidene fluoride-based sensors
External strategies such as electrode design, stress/heat transfer improvements, microstructure optimization, and multifunctional synergy show great potential for improving sensing performance of PVDF-based sensors. Images reproduced with permission, full details in paper.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05200E
Recent advances in multimodal mechanoluminescent sensors enabled by nanostructure design
Multifunctional coupling and signal decoupling achieved through nanostructure and supramolecule design, enable multimodal mechanoluminescent materials to play an increasingly important role in interdisciplinary applications and cutting-edge fields.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04875J

Sustainable nanofibrous membranes for air filtration, water purification and oil removal
The increasing demand for sustainable solutions to address environmental and energy challenges has driven the development of advanced materials. This paper highlights recent advancements in the development of sustainable nanofibrous membranes.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04673K
Colloidal semiconductor quantum shells for solution-processed laser applications
Laser diodes based on solution-processed semiconductor quantum dots (QDs) present an economical and color-tunable alternative to traditional epitaxial lasers.
Nanoscale, 2025,17, 3698-3707
https://doi.org/10.1039/D4NR04653F
Leveraging the dual role of ROS in liver diseases with nanomaterials: clearing and amplifying for therapy
The dual role of ROS in liver diseases, and the potential of nanomaterials with catalytic activity for therapeutic applications are examined.
Nanoscale, 2025,17, 3688-3697
https://doi.org/10.1039/D4NR04469J
NIR-II upconversion nanomaterials for biomedical applications
This review provides a comprehensive overview of recent biomedical applications of upconversion nanomaterials specifically within the near-infrared two-region (NIR-II) window (1000–1700 nm).
Nanoscale, 2025,17, 2985-3002
https://doi.org/10.1039/D4NR04445B
Mathematically inspired structure design in nanoscale thermal transport
Mathematically inspired structure design has emerged as a powerful approach for tailoring material properties, especially in nanoscale thermal transport, with promising applications both within this field and beyond.
Nanoscale, 2025,17, 3003-3013
https://doi.org/10.1039/D4NR04385E

Advances in integrated power supplies for self-powered bioelectronic devices
The emerging integrated power supplies for self-powered bioelectronic devices over the past few years are summarized. Additionally, the challenges and future perspectives in self-powered device design and manufacturing are also indicated.
Nanoscale, 2025,17, 2423-2437
https://doi.org/10.1039/D4NR04645E

Design strategies and performance enhancements of PVDF-based flexible electrolytes for high-performance all-solid-state lithium metal batteries
Lithium metal is considered one of the most promising anode materials for lithium batteries due to its high theoretical specific capacity (3860 mA h g−1) and low redox potential (−3.04 V).
Nanoscale, 2025,17, 2408-2422
https://doi.org/10.1039/D4NR04583A
Organic semiconductor bulk heterojunctions for solar-to-chemical conversion: recent advances and challenges
This minireview highlights recent progress in BHJ-based photoelectrochemical cells and photocatalysts for solar-to-chemical conversions.
Nanoscale, 2025,17, 1889-1921
https://doi.org/10.1039/D4NR03938F
Chiral nanomaterials as vaccine adjuvants: a new horizon in immunotherapy
Chiral nanomaterials are emerging as a promising class of vaccine adjuvants with the potential to significantly enhance vaccine efficacy, especially in the context of cancer immunotherapy.
Nanoscale, 2025,17, 1932-1935
https://doi.org/10.1039/D4NR03542A

Advances in simulating dilute alloy nanoparticles for catalysis
Dilute and single-atom alloy catalysts have attracted tremendous attention in heterogeneous catalysis. Herein, we discuss recent progress on simulating their stability and catalytic behavior.
Nanoscale, 2025,17, 1936-1953
https://doi.org/10.1039/D4NR03761H
Near-infrared circularly polarized luminescence enabled by chiral inorganic nanomaterials
We summarize the latest developments in NIR-CPL generated by chiral inorganic nanomaterials and provide new perspectives for constructing NIR-CPL materials and developing new applications for chiral nanomaterials.
Nanoscale, 2025,17, 1922-1931
https://doi.org/10.1039/D4NR03743J
Bioinspired solid-state nanochannels for molecular analysis
Solid-state nanochannel sensors consisting of recognition elements and nanochannels are capable of detecting a wide range of small molecules including gas molecules, drug molecules and biomolecules.
Nanoscale, 2025,17, 1225-1237
https://doi.org/10.1039/D4NR03711A
Unveiling nanoparticle–immune interactions: how super-resolution imaging illuminates the invisible
This mini-review focuses on how super-resolution techniques uncover the detailed interactions between nanoparticles and immune cells.
Nanoscale, 2025,17, 1213-1224
https://doi.org/10.1039/D4NR03838J

Chirality generation on carbon nanosheets by chemical modification
Chirality is an intriguing property of molecules, and exciting area of study involves the generation of chirality in nanographenes (NGs), also known as graphene quantum dots.
Nanoscale, 2025,17, 774-787
https://doi.org/10.1039/D4NR02952F

Nanoparticle-based drug delivery systems: opportunities and challenges in the treatment of esophageal squamous cell carcinoma (ESCC)
Nanoparticles boost ESCC treatment efficacy by enhancing drug targeting and overcoming biological barriers, despite biocompatibility and scalability challenges.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05114A

Application of functional coatings in water electrolyzers and fuel cells
This review summarizes recent advances in functional coatings in water electrolyzers and fuel cells, covering both compositional design and mechanism understanding of coating materials.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00137D
Research advances of acoustic particle manipulation techniques in field-assisted manufacturing
Acoustic particle manipulation and typical acoustic tweezers are explained. Preparation of microdroplets, microstructured functional surfaces and anisotropic composites via acoustic field-assisted manufacturing (FAM) and applications in biomedical fields are discussed, plus challenges and prospects.
Nanoscale, 2025,17, 5654-5671
https://doi.org/10.1039/D4NR04891A
Metal–organic framework microneedles for precision transdermal drug delivery: design strategy and therapeutic potential
This review explores the synergistic potential of MOF-based MNs and details strategies for integrating MOFs and various guest molecules within MOFs into MNs to enhance transdermal therapeutic applications.
Nanoscale, 2025,17, 5571-5604
https://doi.org/10.1039/D4NR03898C
In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology
Payload delivery systems for DNA- and RNA-based therapies are advancing with viral and non-viral vectors, including lipidic and polymeric nanoparticles. This work highlights their role in oncology, innovations, and use in clinical trials.
Nanoscale, 2025,17, 5501-5525
https://doi.org/10.1039/D4NR05371K
Advanced metal oxide catalysts for propane dehydrogenation: from design strategy to dehydrogenation performance
This review summarizes the design strategy of metal oxide catalysts for PDH, including the suitable supports and the modulated active sites of catalysts. The roles of reaction conditions and advanced characterizations are highlighted.
Nanoscale, 2025,17, 5629-5653
https://doi.org/10.1039/D4NR04482G

Nanomaterial-enabled anti-biofilm strategies: new opportunities for treatment of bacterial infections
Scheme of nano-delivery systems in anti-biofilm application. Created with BioRender.com.
Nanoscale, 2025,17, 5605-5628
https://doi.org/10.1039/D4NR04774E

Self-assembled inorganic nanomaterials for biomedical applications
Self-assembly methods are presented for inorganic nanomaterials used in bioapplications. The most promising in vitro and in vivo results are reported. A discussion on safety and biocompatibility issues, future challenges and prospects is performed.
Nanoscale, 2025,17, 5526-5570
https://doi.org/10.1039/D4NR04537H
Advanced flexible self-healing triboelectric nanogenerators for applications in complex environments
Advanced flexible self-healing triboelectric nanogenerators (F-TENGs) achieve reliable energy harvesting in harsh environments, enabling sustainable wearable electronics and sensors through dynamic material innovations.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05170J
Advanced disease therapeutics using engineered living drug delivery systems
This review highlights how smart nanomaterials overcome biological barriers by enhancing targeting, reducing off-target effects, and enabling controlled drug release. Created in BioRender. Orash, A. (2025) https://BioRender.com/g97k271
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05298F

Recent advances in the fundamentals and in situ characterizations for mechanics in 2D materials
This review involves advances in the mechanics of 2D materials, including measurement methods, sample transfer, materials design, and mechanisms covering the impact of defects and thickness for highly-bendable 2D materials.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05171H
Recent advances in MXene nanozyme-based optical and electrochemical biosensors for food safety analysis
Utilization of MXene nanozymes in electrochemical and optical biosensors for food safety.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00066A
Single photon generation from quantum dots: recent advances, challenges and future directions
Single photon sources (SPS) enable precise quantum communication, secure encryption and quantum computing. Recent research highlights quantum dots as ideal candidates for SPS due to their tunable emission, high stability, brightness and scalability.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR00091B
Synergistic effect between bacteriophages and nanozymes for introducing hybrid dual recognition of pathogenic bacteria from water and agricultural samples: Promising new tools for sensitive and specific biosensors
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR00146C
Recent progress on transition metal dichalcogenide-based composites for cancer therapy
In this review, we present the recent progress on transition metal dichalcogenide-based composites, including their typical categories, key fabrication strategies, and transformative roles in the field of cancer therapy.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05510A
Recent advances in functional lipid-based nanomedicines as drug carriers for organ-specific delivery
The review highlights lipid-based nanomedicines (LBNs) for organ-specific delivery, focusing on functionalization strategies to improve target specificity, drug stability, therapeutic outcomes, and reduce side effects in clinical applications.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04778H
Pd-based chalcogenides for energy conversion electrocatalysis
This review systematically summarizes the recent advances in the use of Pd-based chalcogenides as electrocatalysts for energy conversion reactions.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05230G
Modulation anisotropy of nanomaterials toward monolithic integrated polarization-sensitive photodetectors
This review provides an overview of linear, circular, and full-Stokes photodetectors, discussing how to simplify their design from complex to simple. Images by permission of: RSC 2021, WLY 2023, Optica Publishing Group 2016 and ACS 2020.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05034G
Carbon dots derived from organic drug molecules with improved therapeutic effects and new functions
This article reviews the functions of drug-derived CDs compared with their precursors and demonstrates their broad application prospects in biomedicine.
Nanoscale, 2025,17, 4958-4973
https://doi.org/10.1039/D4NR04467C
NH2-MIL-125(Ti) and its functional nanomaterials – a versatile platform in the photocatalytic arena
Versatile photocatalytic applications of NH2-MIL-125(Ti) and its functional nanomaterials.
Nanoscale, 2025,17, 4906-4957
https://doi.org/10.1039/D4NR03774J
The impact of antimony on all-inorganic lead-free perovskites: progress in optical advancement and applications
We present a comprehensive overview of the recent progress in the rational design of Sb3+ and other BIII cation doping in Cs2BIBIIIX6 DPs, along with their remarkable applications in optoelectronic devices.
Nanoscale, 2025,17, 4892-4905
https://doi.org/10.1039/D4NR04102J
Printing rare-earth-free (REF) magnetic inks: synthesis, formulation, and device applications
This review highlights recent advances in additive manufacturing of rare-earth-free (REF) magnetic materials, emphasizing innovations in material synthesis, ink formulation, printing techniques, and device applications.
Nanoscale, 2025,17, 4830-4853
https://doi.org/10.1039/D4NR04035J
Bioactive surface-functionalized MXenes for biomedicine
This work reviews the surface modification strategies and biomedical applications of MXene, discusses the challenges, trends and prospects of MXenes nanomaterials, which provides information for enhancing the clinical translation of nanomedicine.
Nanoscale, 2025,17, 4854-4891
https://doi.org/10.1039/D4NR04260C
Manganese-based nanoenzymes: From catalytic chemistry to design principle and antitumor/antibacterial therapy
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR00107B
Nanophotonic biosensors for COVID-19 detection: advances in mechanisms, methods, and design
The growing societal impact of coronavirus disease 2019 (COVID-19) has underscored the urgent need for innovative strategies to address the ongoing challenges posed by the pandemic.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04423A

Understanding the interplay between pH and charges for theranostic nanomaterials
Nanotechnology enables targeted theranostics by enhancing imaging and therapy. This review explores advances in pH-induced charge-switchable nanomaterials, their role in drug delivery and imaging contrast, and future directions in the field.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR03706E

Optical Label-Free Microscopy Characterization of Dielectric Nanoparticles
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D4NR03860F

Germanium nanocrystal non-volatile memory devices: fabrication, charge storage mechanism and characterization
The charge storage mechanism of Ge nanocrystals is associated with the reduction, by hydrogen species, of Si–O–Ge bonds, which are located at the outer surface of the Ge nanocrystals where the Ge atoms form bonds with the silicon oxide matrix.
Nanoscale, 2025,17, 4195-4211
https://doi.org/10.1039/D4NR05159A

From synthesis to application: a review of BaZrS3 chalcogenide perovskites
This review covers BaZrS3 thin-film synthesis methods, optical, optoelectronic, electronic, and defect properties, and highlights device applications.
Nanoscale, 2025,17, 4250-4300
https://doi.org/10.1039/D4NR03880K
Chirality of sub-nanometer nanowires/nanobelts
In this review, we summarize the origination, transfer and amplification of chirality in sub-nanometer nanowires/nanobelts (SNWs/SNBs).
Nanoscale, 2025,17, 4328-4337
https://doi.org/10.1039/D4NR05262E
Electrocatalytic reduction of CO2 to produce the C2+ products: from selectivity to rational catalyst design
Electrocatalytic reduction of CO2 (eCO2RR) into valuable multi-carbon (C2+) products is an effective strategy for combating climate change and mitigating energy crises.
Nanoscale, 2025,17, 4338-4364
https://doi.org/10.1039/D4NR04159C
2D monolayer electrocatalysts for CO2 electroreduction
Through bridging the gap between 2D material and single-atom material, 2D monolayer materials exhibit great potential in CO2RR due to their unique structural/electronic properties, high atom utilization and low mass transfer resistance.
Nanoscale, 2025,17, 4212-4225
https://doi.org/10.1039/D4NR04109G
Recent advances in nanoporous organic polymers (NPOPs) for hydrogen storage applications
Nanoporous organic polymers (NPOPs) as versatile materials with robust thermal stability, large surface area, and customizable porosity, making them ideal candidates for advanced hydrogen (H2) storage applications.
Nanoscale, 2025,17, 4226-4249
https://doi.org/10.1039/D4NR03623A
Innovative applications of MXenes in dialysis: enhancing filtration efficiency
The purpose of this review is to comprehensively explore the multifaceted applications of MXenes and their composites in dialysis, highlighting challenges and future directions.
Nanoscale, 2025,17, 4301-4327
https://doi.org/10.1039/D4NR04329D
Ultrafast chirality-dependent dynamics from helicity-resolved transient absorption spectroscopy
Helicity-resolved transient absorption spectroscopy enables the mechanistic understanding of the ultrafast dynamics of chirality and chiroptics in micro- and nano-chiral materials.
Nanoscale, 2025,17, 4175-4194
https://doi.org/10.1039/D4NR03682D

Latest developments in the synthesis of metal–organic frameworks and their hybrids for hydrogen storage
Metal–organic frameworks (MOFs) are promising materials for hydrogen (H2) storage due to their versatile structures, high surface areas and substantial pore volumes.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR03969F
Recent progress in non-noble metal nano-electrocatalysts for hybrid water splitting
This review provides a comprehensive overview of the recent progress in non-noble metal-based nanocatalysts for hybrid water splitting, including fundamental concepts, catalysts design, reaction mechanism and typical hybrid water splitting systems.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04915B
Insight into the structural reconstruction of alkaline water oxidation electrocatalysts
This review explores precatalysts’ structural reconstruction during alkaline OER, summarizes methods probing structural evolution and influencing factors, guides dynamic reconstruction regulation, and discusses reconstruction impacts on performance.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR05426A

Recent advances in fundamental research on photon avalanches on the nanometre scale
Overview of photon avalanche upconversion: history, imaging applications, photonic applications, and challenges for frontier applications. Image created with BioRender.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR03493G
Nanoscale high-entropy alloys for solar and thermal applications
This review highlights the advantages of non-annealing synthesis, emphasizing the importance of in situ characterization, multi-level simulations and machine learning to accelerate photo-/thermocatalytic research in nanoscale high-entropy alloys.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04697H
Engineering the next generation of MXenes: challenges and strategies for scalable production and enhanced performance
Optimization strategy of MXene scale preparation.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04560B
Synergizing superwetting and architected electrodes for high-rate water splitting
Review of recent advancements in tackling bubble-related issues through the design and implementation of superwetting electrodes, including surface modification techniques and structural optimizations.
Nanoscale, 2025,17, 3600-3615
https://doi.org/10.1039/D4NR03836C

Advances and applications of dynamic surface-enhanced Raman spectroscopy (SERS) for single molecule studies
Dynamic SERS is a promising tool to capture in situ molecular fingerprints in complex chemical and biological systems, with continuously evolving sensitivity and temporal resolution.
Nanoscale, 2025,17, 3656-3670
https://doi.org/10.1039/D4NR04239E
Recent advances in mRNA-based therapeutics for neurodegenerative diseases and brain tumors
mRNA-based therapeutics have entered the mainstream with seemingly limitless possibilities to treat neurodegenerative diseases and brain tumors.
Nanoscale, 2025,17, 3537-3548
https://doi.org/10.1039/D4NR04394D
Emerging devices based on chiral nanomaterials
Chiral nanomaterials, as a class of advanced materials, have recently attracted extensive attention on account of their unique physical and chemical properties that stem from their special geometry.
Nanoscale, 2025,17, 3585-3599
https://doi.org/10.1039/D4NR03998J
Advances in precise synthesis of metal nanoclusters and their applications in electrochemical biosensing of disease biomarkers
Metal nanoclusters as advanced electrode materials to achieve electrochemical biosensing of diverse disease-associated biomarkers.
Nanoscale, 2025,17, 3616-3634
https://doi.org/10.1039/D4NR04714A
Recent advances in poly(amino acids), polypeptides, and their derivatives in drug delivery
This review systematically describes the preparation of poly(amino acids) and peptides, and their use in drug loading for various diseases, offering insights for research and clinical applications of degradable biomedical polymers.
Nanoscale, 2025,17, 3549-3584
https://doi.org/10.1039/D4NR04481A
Biomolecular ligands as tools to modulate the optical and chiroptical properties of gold nanoclusters
This review highlights advances in the use of biomolecular ligands to synthesize gold nanoclusters, factors affecting their optical and chiroptical features, and applications in biosensing, bioimaging, and theranostics.
Nanoscale, 2025,17, 3671-3687
https://doi.org/10.1039/D4NR04267K
Recent advances in SERS assays for detection of multiple extracellular vesicles biomarkers for cancer diagnosis
This review provides insights on recent advances using label-free and label-based SERS assays for detecting multiple small extracellular vesicle biomarkers for cancer diagnosis, including issues surrounding their translation from lab to clinic.
Nanoscale, 2025,17, 3635-3655
https://doi.org/10.1039/D4NR04014G
Electrocatalytic biomass upgrading coupled with hydrogen evolution and CO2 reduction
This review gives a detailed summary on the biomass upgrading coupled with electrocatalytic hydrogen evolution and CO2 reduction, with critical challenges and perspectives provided to inspire more efforts in pushing forward the future development.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D4NR04433A
About this collection
In addition to high impact and high quality research across nanoscience & nanotechnology, Nanoscale publishes topical review articles. Reviews will be added to this webpage as soon as possible after publication.