To discover promising therapeutic agents, novel diaryl pyrimidine linked acyl thiourea derivatives (6a–j) were designed and synthesized via straightforward and multistep synthesis.
Dihydrofolate reductase (DHFR) is a crucial enzyme involved in folate metabolism and serves as a prime target for anticancer and antimicrobial therapies.
We present key methodologies, illustrated with key case studies, to enable the study of supramolecular amphiphiles and support technology translation.
A series of new benzimidazole–dioxo(benzo)isoindoline conjugates were designed and synthesized as dual VEGFR-2 and FGFR-1 inhibitors. Compound 8m demonstrated potent % inhibition of 80.69% and 76.83% on VEGFR-2 and FGFR-1 at 10 μM, respectively.
A library of piperate derivatives 3–25 was synthesized in a two-step reaction scheme starting from piperine 1, which was converted to piperic acid 2 first, and then reacted with various alkyl and aryl halides to afford the final products.