Hina Zaman, Aamer Saeed, Hammad Ismail, Sadaf Anwaar, Muhammad Latif, Muhammad Zaffar Hashmi and Hesham R. El-Seedi
RSC Adv., 2024,14, 33235-33246
Abstract
To discover promising therapeutic agents, novel diaryl pyrimidine linked acyl thiourea derivatives (6a–j) were designed and synthesized via straightforward and multistep synthesis.
Hina Aftab, Saeed Ullah, Ajmal Khan, Mariya al-Rashida, Talha Islam, Abdulrahman Alshammari, Norah A. Albekairi, Parham Taslimi, Ahmed Al-Harrasi, Zahid Shafiq and Saeed Alghamdi
RSC Adv., 2024,14, 31409-31421
Abstract
Dihydrofolate reductase (DHFR) is a crucial enzyme involved in folate metabolism and serves as a prime target for anticancer and antimicrobial therapies.
Thomas Allam, Dominick E. Balderston, Mandeep K. Chahal, Kira L. F. Hilton, Charlotte K. Hind, Olivia B. Keers, Rebecca J. Lilley, Chandni Manwani, Alix Overton, Precious I. A. Popoola, Lisa R. Thompson, Lisa J. White and Jennifer R. Hiscock
Chem. Soc. Rev., 2023,52, 6892-6917
From themed collection:
Supramolecular Chemistry
Abstract
We present key methodologies, illustrated with key case studies, to enable the study of supramolecular amphiphiles and support technology translation.
Heba T. Abdel-Mohsen and Amira M. Nageeb
RSC Adv., 2024,14, 28889-28903
Abstract
A series of new benzimidazole–dioxo(benzo)isoindoline conjugates were designed and synthesized as dual VEGFR-2 and FGFR-1 inhibitors. Compound 8m demonstrated potent % inhibition of 80.69% and 76.83% on VEGFR-2 and FGFR-1 at 10 μM, respectively.
Mohamed Azzouzi, Abderrahim Ait Ouchaoui, Omar Azougagh, Salah Eddine El Hadad, Mohamed Abou-salama, Adyl Oussaid, Christophe Pannecouque and Taoufik Rohand
RSC Adv., 2024,14, 36902-36918
Abstract
Imidazo[1,2-a]pyridine-Schiff base derivatives were synthesized, characterized, and evaluated for their anti-HIV potential. Molecular docking and ADME were performed and discussed.