We characterize an ionic cocrystal of ponatinib HCl using X-ray diffraction and solid-state NMR. Multinuclear NMR, with ultra-high fields up to 35.2 T, lays the groundwork for characterization of complex crystals in the absence of diffraction data.
We developed a fully integrated microfluidic drug screening platform, combining centrifugal cell loading, automated flow control, and single-cell-resolution image analysis to enable quantitative, patient-specific therapeutic assessment.
The top-ranked ligand for FGFR1 kinase reveals a spectrum of interaction states, as uncovered by LiGaMD simulation.
Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines.
Stimulated Raman scattering (SRS) microscopy provides unique opportunities for molecular imaging in preclinical drug evaluation.