External ligand-free Pd-catalyzed arylation achieving an exclusive switch in regioselectivity from α- to β position of N-vinyl-7-azaindoles via an N-oxide activation strategy.
Cancer remains a major global health challenge and a leading cause of mortality. This ongoing burden underscores the need for continuous exploration of novel therapeutic strategies, prompting extensive review of emerging targets, mechanisms, and treatment approaches.
Dowtherm-A mediated facile synthesis of 2-aroyl 7-azaindoles via a hetereoannulation strategy.
This review presents various new strategies for the functionalization of 5 and 6-membered fused heteroaromatics. These synthetic strategies enable rapid access to complex heterocyclic compounds.
A scalable and efficient synthesis of 2-trifluoromethyl-3-trifluoroacetyl-6-azaindoles from 3-amino-4-methylpyridines under treatment with TFAA is disclosed. Activation of the methyl group in aminomethylpyridines under mildly acidic conditions appeared promising for expanding substrate scope.