A practical synthesis of new β-difluoromethoxy vinyl sulfones has been explored by O-difluoromethylation of β-ketosulfones using the inexpensive and easily workable sodium chlorodifluoroacetate as a difluorocarbene precursor.
This study explores novel isoxazole-based small molecules, identifying compound 7l with potent antiviral activity against Zika virus (ZIKV) and an improved safety profile in vitro, highlighting its potential as a promising candidate for therapeutic development.
Experimental studies on a five-ring ester-difluoromethoxy linked ferroelectric nematic liquid crystal.
We report the discovery of a new series of 3H-spiro[benzofuran-2,4′-piperidine] IRAK4 inhibitors as potential anti-DLBCL agents.
Free and metal difluorocarbenes reacted with (thio)carbonyl compounds and silyl dienol ethers to provide difluoromethyl (thio)ethers, ring-fluorinated carbo/heterocycles and difluoroalkenes.