A practical synthesis of new β-difluoromethoxy vinyl sulfones has been explored by O-difluoromethylation of β-ketosulfones using the inexpensive and easily workable sodium chlorodifluoroacetate as a difluorocarbene precursor.
This study explores novel isoxazole-based small molecules, identifying compound 7l with potent antiviral activity against Zika virus (ZIKV) and an improved safety profile in vitro, highlighting its potential as a promising candidate for therapeutic development.
Experimental studies on a five-ring ester-difluoromethoxy linked ferroelectric nematic liquid crystal.
Free and metal difluorocarbenes reacted with (thio)carbonyl compounds and silyl dienol ethers to provide difluoromethyl (thio)ethers, ring-fluorinated carbo/heterocycles and difluoroalkenes.
In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.