Catalytic asymmetric formal (2 + 3) cycloaddition involving methyl-substituted 2-indolylmethanols

Si-Jia Liu, Tian-Zhen Li, Ning-Yi Wang, Qi Cheng, Yinchun Jiao, Yu-Chen Zhang and Feng Shi

Org. Chem. Front., 2024, 11, 4812
DOI: 10.1039/D4QO01047G

Catalytic asymmetric reactions of indolylmethanols for the synthesis of chiral indole derivatives

Yu-Die Wang, Wen-Yu Luan, Chun Ma and Feng Shi

Chem. Commun., 2026, 62, 1109
DOI: 10.1039/D5CC06044C

Substituent-dependent [4+2] or [2+2] cycloadditions of phenylallenyl phosphine oxides with arynes

Yunlong Qin, Jianing Zhang, Congcong Zhang and Qilin Wang

Chem. Commun., 2024, 60, 11343
DOI: 10.1039/D4CC03507K

Mechanisms and regio- and stereoselectivities in NHC-catalyzed [3+3] annulations for the synthesis of axially and centrally chiral dihydropyridinones

Yanlong Kang, Mingchao Zhang, Yan Li and Zhiqiang Zhang

Phys. Chem. Chem. Phys., 2026, 28, 730
DOI: 10.1039/D5CP03567H

Synthesis of chiral spiro-heterocyclic azides via asymmetric [4 + 2]-cycloaddition of conjugated vinyl azides

Yican Lu, Yinhe Qu, Bingqian Yang, Hailong Zhang, Weidi Cao and Xiaoming Feng

Org. Chem. Front., 2026, 13, 64
DOI: 10.1039/D5QO01290B

Enantioselective addition of 3-hydroxyquinolin-2(1H)-one to isatin and pyrazole-4,5-dione derived ketimines

Yue Wei, Guishun Bai, Jiamin Wu, Yi Hua, Tao Zhang, Congyong Yue, Hong Wang and Xiaoze Bao

Org. Chem. Front., 2025, 12, 497
DOI: 10.1039/D4QO01895H

Synthesis of pyrazoline-derived N-vinyl nitrones through an unexpected selective [3 + 2] cycloaddition

Pei-Wen Qiu, Li-Bing Yan, Li-Fen Ning, Chun-Hua Chen, Hong-Yan Bi and Dong-Liang Mo

Org. Chem. Front., 2025, 12, 3403
DOI: 10.1039/D4QO02317J

Asymmetric [3 + 3] cycloaddition of cinnamaldehyde-derived N-aryl nitrones with 2-indolemethanols enabled by chiral phosphoric acid

Ning Zou, Yu-Zheng Wu, Zi-Wei Shang, Yu-Wei Cao, Li-Min Liao, Cui Wei, Dong-Liang Mo and Wen-Jun Zhou

Org. Biomol. Chem., 2024, 22, 9047
DOI: 10.1039/D4OB01365D

Stereoselective construction of 5-6-5 aza-tricyclic scaffolds via catalytic asymmetric aza-Piancatelli/Diels–Alder reactions

Lishu Wang, Han Wang, Xukun Nie, Jun Li, Yurong Tang and Yunfei Cai

Chem. Commun., 2025, 61, 8395
DOI: 10.1039/D5CC01888A

Recent advances in chiral phosphoric acids for asymmetric organocatalysis: a catalyst design perspective

Peng-Fei Zhao, Ke Wang, Jia-Xu Wen, Zhang-Mei-Duo Zhu, Hua Zhang, Zi-Heng Wang, Yu-Xin Liao, Chao-Shan Da and Zhi-Hong Du

Org. Biomol. Chem., 2025, 23, 7872
DOI: 10.1039/D5OB00719D

Biaxially chiral compounds: research and development of synthesis

Kongling Feng, Chaochao Yao and Hao Xu

Chem. Commun., 2025, 61, 2217
DOI: 10.1039/D4CC04701J

Switchable divergent organocatalytic asymmetric reactions of azlactones with 1,4-enediones

Luyao Li, Dandan Pan, Gongming Zhu, Chenhe Su and Bo Zhu

Org. Chem. Front., 2025, 12, 3417
DOI: 10.1039/D5QO00280J

Organocatalytic asymmetric [3+3] annulation reaction between 5-aminopyrazoles and enynones: synthesis of pyrazolo[3,4-b]pyridines

Dipali Digangana Sahoo and Subhas Chandra Pan

Chem. Commun., 2026, 62, 7369
DOI: 10.1039/D6CC01164K

Organocatalytic asymmetric synthesis of fluorinated pyranopyrazoles

Jianfeng Mu, Aining Dong, Menghan Yang, Hongyu Zhang, Guoshun Zhang, Xiaochen Wang, Bei Wei and Shurong Ban

Org. Chem. Front., 2026, 13, 2424
DOI: 10.1039/D6QO00005C

Catalytic enantioselective and site-specific Friedel–Crafts alkylation of 4-aminoindoles with β,γ-alkynyl-α-ketoimines for the synthesis of C7-functionalized indoles

Lei Yang, Xue-Man Zhang, Juan Liao, Yan-Ping Zhang, Zhen-Hua Wang, Yong You, Jian-Qiang Zhao and Wei-Cheng Yuan

Org. Chem. Front., 2025, 12, 655
DOI: 10.1039/D4QO01856G

Crab-shape C2-symmetric chiral Tpy-bisulidine ligands: design, synthesis and application in diversity-oriented asymmetric catalysis

Wu-Wu Li, Hong-Xing Cen, Di-Cheng Pan, Lin-Lu Liu, Li-Jun Peng, Zi-Hong Hu and Xiong-Li Liu

Org. Chem. Front., 2026, 13, 1768
DOI: 10.1039/D5QO01530H

One-pot (2 + 4) cycloaddition of propargyl alcohols with o-hydroxyphenyl substituted secondary phosphine oxides

Sen Zhang, Guo-Ke Zhang, Yi-Ming Tian, Wen-Xin Bai, Tian-Ya Liu and Yu-Chen Zhang

Org. Biomol. Chem., 2025, 23, 9178
DOI: 10.1039/D5OB01347J

Enantioselective Synthesis of Helically Chiral Molecules Enabled by Asymmetric Organocatalysis

Qingqin Huang, Yu-Ping Tang, Chao-Gang Zhang, Zhen Wang and Lei Dai

ACS Catal., 2024, 14, 16256
DOI: 10.1021/acscatal.4c05345

Dual Activation of Enals and γ‐C(sp3)‐H Bond of p‐Quinols for the Synthesis of Naphthylamines via Cyclization/Dual Aromatization

Junsheng Zhi, Liping Deng, Weijie Huang, Long Sun, Lou Shi, Yifei Li, Qun Liu and Ling Pan

Chin. J. Chem., 2025, 43, 2630
DOI: 10.1002/cjoc.70148

Skeletal Editing of Hydroxyl Oxindoles via Organoiodine‐Catalyzed Oxygen Atom Insertion Reaction

Yang Wang, Xin‐Zhi Zhou, Xin‐Yan Ke, Yue Wang, Shao‐Fei Ni and Feng Shi

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202519764

Synthesis of Indole‐Fused Eight‐Membered Heterocycles via Rh(III)‐Catalyzed NH‐Indole‐Directed C–H Activation/[5+3] Annulation of 7‐Phenylindoles with Methyleneoxetanones

Piao Lu, Siqi Zhang, Xiao Tan, Shao‐Fei Ni and Qiufeng Huang

Chin. J. Chem., 2026, 44, 1097
DOI: 10.1002/cjoc.70450

o-Quinone Methide-Involved Chemoselective and Diastereoselective [2＋3] Annulation

Ziqi Zhu, Lehua Ye, Yi Wu, Ziqi Guo and Feng Shi

Acta Chimica Sinica, 2025, 83, 1465
DOI: 10.6023/A25070265

Synthesis of Indole‐Fused Chromane‐Based Spirooxindoles via Brønsted Acid‐Catalyzed Regioselective [5+1] Annulation

Le‐Hua Ye, Xiao Cheng, Zi‐Qi Zhu and Feng Shi

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202401405

Organocatalytic Asymmetric Cycloaddition for the Construction of Chiral Indole‐Fused Medium‐ and Large‐Sized Rings

Bo‐Wen Lai, Hao‐Hui Zhang, Bo‐Xuan Yao, Rui Li, Shao‐Fei Ni, Kuiyong Dong and Feng Shi

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202507804

Substrate‐Dependent Asymmetric Allylic Alkylation of Morita–Baylis–Hillman Carbonates with 3‐Alkylidene Oxindoles

Bo‐Wei Huang, Yun‐Jie Tsou and Jeng‐Liang Han

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.70027

Halogen Bond-Driven Oxa-Pictet–Spengler Cyclization Using CBr₄: A Metal-Free and Regioselective Approach for the Synthesis of Tetracyclic Dihydrochromenoindole Scaffolds

Diksha Bansal, Pooja Sivaganesan, Ghanashyam Sivaprasad, Janani Ilango, Mrinal K. Das and Saikat Chaudhuri

Synlett, 2026, 37, 361
DOI: 10.1055/a-2711-1613

Phosphine-Catalyzed [5＋1] Annulation of Morita-Baylis-Hillman Carbonates with 1,3-Dicarbonyl Compounds

Yue Ren, Wangyu Shi, Yi Tang and Hongchao Guo

Chinese Journal of Organic Chemistry, 2024, 44, 3739
DOI: 10.6023/cjoc202405039

Organocatalytic γ,γ‐Regioselective Formal (1+5) Cycloaddition of Isoindolinone‐Derived Propargylic Alcohols

Li‐Ying Jiang, Guo‐Ke Zhang, Yiming Tian, Sen Zhang, Yi Wang, Da‐Hua Wang and Yu‐Chen Zhang

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202401444

Organocatalytic Asymmetric Cycloaddition for the Construction of Chiral Indole‐Fused Medium‐ and Large‐Sized Rings

Bo‐Wen Lai, Hao‐Hui Zhang, Bo‐Xuan Yao, Rui Li, Shao‐Fei Ni, Kuiyong Dong and Feng Shi

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202507804

Thiourea‐Amine Catalysts: Innovation, Integration, and Sustainability

Honghua Zhang, Yujun Qiao, Haile Chen and Yinliang Bai

Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.202500582

Enantioselective Synthesis of Nonfused Eight-Membered O-Heterocycles by Sequential Catalysis

Suo-Suo Qi, Xiao-Ping Sun, Yan-Biao Sun, Jing-Jing Zhai, Yi-Feng Wang, Shao-Jie Lou and Dan-Qian Xu

Org. Lett., 2025, 27, 340
DOI: 10.1021/acs.orglett.4c04253

Catalytic Asymmetric Construction of Nonadjacent Stereoelements

Chong‐Lei Ji, Xi‐Zhang Zou and De‐Wei Gao

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202504224

Chiral Phosphoric Acid-Catalyzed Enantioselective Synthesis of 2,2-Disubstituted 2,3-Dihydro-4-quinolones from Isatins and 2′-Aminoacetophenones

Hidenori Andatsu, Yuto Terashima, Rio Kawamura, Yoichiro Matsuda, Tsunayoshi Takehara, Takeyuki Suzuki, Naoki Yasukawa and Shuichi Nakamura

Org. Lett., 2025, 27, 258
DOI: 10.1021/acs.orglett.4c04249

Lewis Acid Catalyzed Regioselective Substitution of 2-Indolylmethanols with Pyrroles

Jun-Nan Gao, Wen-Xin Tan, Shuang Yang, Ning-Yi Wang, Jiebin Han, Da-Hua Wang, Yu-Chen Zhang and Feng Shi

Synthesis, 2025, 57, 1189
DOI: 10.1055/a-2503-3181

An Unusual Chemoselective Cycloaddition of Nonstabilized Azomethine Ylide: Synthesis of Oxazolidine Derivatives

Xiaolin Li, Jiahao Xu, Xiang Gao, Xiang Ren, Bowen Hu, Jian Yang, Yulong Zhang and Yushuang Chen

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.70392

Organocatalytic syn-Selective [3 + 2]/[4 + 2] Annulations of (E)-Pyrazoloneyldiene Oxindole

Jialiang Qin, Yuzhen Chen, Wenhong Suo, Xiaodong Han, Weihong Liang, Huicai Huang and Bo Liu

Org. Lett., 2025, 27, 12070
DOI: 10.1021/acs.orglett.5c03738

B(C6F5)3-Catalyzed Multicomponent Reactions of 2,3-Diketoesters, Amines, Allenes, and Nucleophiles: Synthesis of 2α-Functionalized Pyrroles

Wei-Wei Zhang and Qiang Sha

J. Org. Chem., 2024, 89, 12286
DOI: 10.1021/acs.joc.4c01221

Bro̷nsted Acid-Catalyzed Regioselective [5 + 1] Annulation for the Synthesis of Indole-Fused Dihydrochromanes

Si-Yi Liu, Lu Fan, Zi-Qi Zhu and Feng Shi

J. Org. Chem., 2024, 89, 16791
DOI: 10.1021/acs.joc.4c02101

Organocatalytic Asymmetric Oxa‐[3+3]‐annulation for Chiral Tricyclic Chromans with Contiguous Stereocenters

Meng‐Yuan Wu, Xu‐Yi Huang, Beiling Gao and Guang‐Jian Mei

Chin. J. Chem., 2026, 44, 47
DOI: 10.1002/cjoc.70309

Recent Advances in Organocatalytic Enantioselective Reactions of α‐Functionalized Propargylic Alcohols

Yan Xia, Meiwen Liu, Wenjun Li and Pengfei Li

Asian J Org Chem, 2024, 13
DOI: 10.1002/ajoc.202400377

Pentafluorophenol (C6F5OH) catalyzed Regioselective annulation for the synthesis of tetracyclic Dihydrochromeno indoles

Diksha Bansal, Pooja Sivaganesan, Gokulprasanth Nataraj, Chibisree Elanchezhian, Mrinal Kanti Das and Saikat Chaudhuri

Tetrahedron Letters, 2025, 165-166, 155660
DOI: 10.1016/j.tetlet.2025.155660

Dynamic Kinetic Resolution of Azlactones with Hydrazines via Negative Catalysis: Synthesis of α-Chiral Amino Acid Hydrazides and Their Preferential Enrichment Phenomenon

Sungyong Won, Yuta Yamaguchi, Yasutaka Kawai, Yuki Kono, Masato Ichikawa, Eiji Yamamoto, Takashi Kamachi, Akina Yoshizawa and Makoto Tokunaga

ACS Catal., 2025, 15, 16197
DOI: 10.1021/acscatal.5c02848

Organophosphoric Acid Catalyzed [3＋3] Cyclization for the Synthesis of Indenoquinolinedione Derivatives

Xinyan Guo, Haolei Yu, Honglin Wan, Yu Lu, Wei Tan and Feng Shi

Chinese Journal of Organic Chemistry, 2024, 44, 3727
DOI: 10.6023/cjoc202405040

Asymmetric Organocatalyzed Michael/Oxa-Michael Domino Reaction of Isoxazole-5-ones with 1,3-Nitroenynes: Access to Chiral Fused Dihydropyranisoxazolines

Akanksha Santosh Deshpande, Chhavi Khajuria, Rohtash Kumar and Vinod K. Singh

J. Org. Chem., 2026, 91, 2215
DOI: 10.1021/acs.joc.5c02955

Highly Enantioselective Construction of Chiral Eight-Membered Cyclic Ethers through Tandem Cyclization of Ynones and Dicarbonyl Compounds

Yuzhen Chen, Peishan Gu, Jialiang Qin, Huicai Huang and Yongbo Xue

J. Org. Chem., 2024, 89, 16736
DOI: 10.1021/acs.joc.4c02034

Organocatalytic Asymmetric (3+3) Cycloaddition of 4‐Hydroxycoumarins with α,β‐Unsaturated Aryl Esters

Hao Chen, Shuang Yang, Ning‐Yi Wang, Ya‐Ping Tian, Yu‐Chen Zhang and Feng Shi

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202401925

Copper-Catalyzed Oxidative (4 + 2) Cycloaddition of 2-Arylindoles and 2-Aminophenols To Prepare Indole-Fused 1,4-Benzoxazines

Wei-Min Shi, Pei-Sen Zou, Ke Huang, Hong-Yan Bi, Xiao-Pan Ma and Dong-Liang Mo

J. Org. Chem., 2026, 91, 2939
DOI: 10.1021/acs.joc.5c03088

Synthesis of 4‐Indolyl‐5‐Aminopyrazoles via Catalytic Arylation of 5‐Aminopyrazoles With 2‐Indolylmethanols

Yu‐Yu Chen, Tian‐Ya Liu, Jia Xue, Cheng‐Ye Xu, Yu‐Chen Zhang and Feng Shi

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202500861

DABCO-catalyzed [3+4] annulations of Schiff bases with α-substituted allenes: Construction of functionalized benzazepine derivatives

Ke Wu, Xiuqin Ruan, Shuolei Jia, Enyuan Wang and Qingfa Zhou

Chinese Chemical Letters, 2025, 36, 110646
DOI: 10.1016/j.cclet.2024.110646

Asymmetric Organocatalytic Benzylation of Morita–Baylis–Hillman Carbonates with 2,4-Dinitrotoluene Derivatives

Yu-Da Wu, Bo-Wei Huang, Yu-Chun Chen and Jeng-Liang Han

Synthesis, 2024, 56, 3181
DOI: 10.1055/a-2361-0011

In(OTf)3-Catalyzed [3 + 2] Cycloaddition Reactions of Donor–Acceptor Cyclopropanes with Thioamides

Chen-Ying Zhai, Wen-Zhi Zhao, Yue Lu and Yan Jiang

J. Org. Chem., 2025, 90, 17705
DOI: 10.1021/acs.joc.5c01959

DMAP‐Catalyzed Efficient Diastereo‐ and Regioselective Synthesis of Isoxazolone‐Based Bisspiroheterocyclic Oxindoles

Rong‐Rong Zhu and Da‐Ming Du

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400959

Synthesis of N,N'‐Bisindoles via Gold‐Catalyzed Formal (4 + 1) Cycloaddition

Hao‐Hui Zhang, Can Yang, Hao‐Cheng Tian, Kuiyong Dong and Feng Shi

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202500193

Skeletal Editing of Hydroxyl Oxindoles via Organoiodine‐Catalyzed Oxygen Atom Insertion Reaction

Yang Wang, Xin‐Zhi Zhou, Xin‐Yan Ke, Yue Wang, Shao‐Fei Ni and Feng Shi

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202519764

Asymmetric Diamination of the In Situ Generated Difluoroenol Species Using Azocarboxamides as an N Source

Xiongda Xie, Xinke Zhang, Gang Chen, Minghan Yao, Cheng Zhang, Yue Pan and Xinfang Xu

ACS Catal., 2025, 15, 18097
DOI: 10.1021/acscatal.5c05967

Base-Promoted Chemodivergent Construction of 2H-Chromen-2-one and Chromeno[2,3-c]pyrrole Scaffolds from para-Quinone Methides and α-Alkylidene Succinimides

Km Roshani, Mohammad Saim Raza and Rama Krishna Peddinti

Org. Lett., 2024, 26, 9114
DOI: 10.1021/acs.orglett.4c03436

Lewis Acid-Enabled Chemodivergent Cycloadditions of Donor–Acceptor Cyclopropanes with Indoline-2-Thiones

Chen-Ying Zhai, Bing Zhao, Xue-Long Wang, Huai-Yan Liu, Bo Zhao and Yan Jiang

J. Org. Chem., 2025, 90, 3209
DOI: 10.1021/acs.joc.4c02791

Synthesis of Trifluoromethylated Spiroisoxazolones via a [3+2] Cycloaddition of Nitrile Imines and Unsaturated Isoxazolones

Wei Zhang and Da-Ming Du

Molecules, 2025, 31, 73
DOI: 10.3390/molecules31010073

Brønsted‐Acid Catalyzed Aldehyde Insertion to Construct C−X Bond: High Regio‐ and Chemoselectivity Synthesis of Dihydrobenzo[1,5]oxazocines and Pyrrolo[3,4‐ d]tetrahydropyrimidines

Yuan‐Min Wen, Teng Liu, Gui‐Yun Zeng, Jun‐Jie Li, Zeng‐Hong Yao, Chi‐Xian He and Chao Huang

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202401287

Organocatalytic Asymmetric [4 + 4] Annulation Reaction of Ynones with Unsaturated Pyrazolones: Synthesis of Eight-Membered Ether-Embedded 4,5-Fused Pyrazoles

Dipankar Barman and Subhas Chandra Pan

Org. Lett., 2025, 27, 5338
DOI: 10.1021/acs.orglett.5c01118

Asymmetric Michael Addition of 3-Chlorooxindoles with Vinylidene Bisphosphonates: Synthesis of 3,3-Disubstituted 3-Chlorooxindoles and Spirocyclopropane-Fused Oxindoles

Si-Jia Wan, Yi-Hu Jin, Ya Li, Youcan Zhang and Ling-Yan Chen

J. Org. Chem., 2026, 91, 4239
DOI: 10.1021/acs.joc.5c03031

Catalytic Asymmetric Construction of Nonadjacent Stereoelements

Chong‐Lei Ji, Xi‐Zhang Zou and De‐Wei Gao

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202504224

Catalytic Asymmetric De Novo Synthesis of Chiral Pyrroles Through Desymmetrizing Oxidative [3+2]‐Cycloaddition and the Van Leusen Reaction

Rupkumar Khuntia, Diptendu Maity and Subhas Chandra Pan

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202404511

Phosphine-Catalyzed [2＋3] Annulation of Aurone-Derived Azadienes with Amino Crotonates

Gang Chen, Dong Chen, Guangjie Nie, Linxuan Li, Hui,Wang,Nengzhong Yao and Nianyu Huang

Chinese Journal of Organic Chemistry, 2025, 45, 2139
DOI: 10.6023/cjoc202501015