Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates

Thomas P. Corner, Eidarus Salah, Anthony Tumber, Lennart Brewitz and Christopher J. Schofield

RSC Chem. Biol., 2025, 6, 642
DOI: 10.1039/D4CB00311J

Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat

Thomas P. Corner, Eidarus Salah, Anthony Tumber, Samanpreet Kaur, Yu Nakashima, Mark D. Allen, Lara I. Schnaubelt, Giorgia Fiorini, Lennart Brewitz and Christopher J. Schofield

ChemMedChem, 2024, 19
DOI: 10.1002/cmdc.202400504

Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase

Thomas P. Corner, Anthony Tumber, Eidarus Salah, Mohammadparsa Jabbary, Yu Nakashima, Lara I. Schnaubelt, Shyam Basak, Faisal M. Alshref, Lennart Brewitz and Christopher J. Schofield

J. Med. Chem., 2025, 68, 9777
DOI: 10.1021/acs.jmedchem.5c00586

FIH‐1 Deletion in Intestinal Epithelial Cells Causes Radioprotection by Activating PI3K‐AKT Pathway

Yuwei Yang, Ziqi Zhang, Haochen Teng, Lixue Ma, Haikang Tang, Xin Meng, Xiaoliang Zhou and Wenqing Xu

The FASEB Journal, 2025, 39
DOI: 10.1096/fj.202403062RR

Biochemistry of the hypoxia-inducible factor hydroxylases

Giorgia Fiorini and Christopher J. Schofield

Current Opinion in Chemical Biology, 2024, 79, 102428
DOI: 10.1016/j.cbpa.2024.102428

Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease

Yue Wu, Zewei Zhang, Haiping Cai, Weiqing Zhang, Linjian Zhang, Zhihong Li, Le Yang, Yafen Chen, Thomas P. Corner, Zhe Song, Jie Yue, Fulai Yang, Xiang Li, Christopher J. Schofield and Xiaojin Zhang

J. Med. Chem., 2025, 68, 212
DOI: 10.1021/acs.jmedchem.4c01698

Light-Induced, Lysine-Targeting Irreversible Covalent Inhibition of the Human Oxygen Sensing Hydroxylase Factor Inhibiting HIF (FIH)

Yue Wu, Zhihong Li, Samanpreet Kaur, Zewei Zhang, Jie Yue, Anthony Tumber, Haoshu Zhang, Zhe Song, Peiyao Yang, Ying Dong, Fulai Yang, Xiang Li, Christopher J. Schofield and Xiaojin Zhang

J. Am. Chem. Soc., 2025, 147, 17871
DOI: 10.1021/jacs.5c01935

The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia

Hannah Lawson, James P. Holt-Martyn, Vilma Dembitz, Yuka Kabayama, Lydia M. Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon, Jozef Durko, Louie N. van de Lagemaat, Azzura L. De Pace, Anthony Tumber, Thomas Corner, Eidarus Salah, Christine Arndt, Lennart Brewitz, Matthew Bowen, Louis Dubusse, Derek George, Lewis Allen, Amelie V. Guitart, Tsz Kan Fung, Chi Wai Eric So, Juerg Schwaller, Paolo Gallipoli, Donal O’Carroll, Christopher J. Schofield and Kamil R. Kranc

Nat Cancer, 2024, 5, 916
DOI: 10.1038/s43018-024-00761-w

Knockout of the fih gene by CRISPR/Cas9 enhances the hypoxia tolerance in grass carp (Ctenopharyngodon idella)

Huimei Zhang, Ziquan Yang, Jianjun Fu, Ziming Yuan, Jie Chen, Rengao Shen, Guodong Zheng, Shuming Zou and Zaijie Dong

Aquaculture, 2025, 604, 742452
DOI: 10.1016/j.aquaculture.2025.742452