Issue 84, 2022

A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones

Abstract

Herein, we report a Pd(0)-catalyzed cascade reaction of intramolecular indolyl isocyanide-insertion, isocyanide-initiated scaffold-rearrangement with indolyl migration and redox-neutral process, which affords an efficient access to indolylisoindolinones. Isocyanide as a C(sp3)H–N synthon and the alkyl motif of isocyanide as a hydride source have been explored for the first time.

Graphical abstract: A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones

Supplementary files

Article information

Article type
Communication
Submitted
31 ஜூலை 2022
Accepted
22 செப்டம்பர் 2022
First published
23 செப்டம்பர் 2022

Chem. Commun., 2022,58, 11827-11830

A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones

S. Sisodiya, A. Acharya, M. Nagpure, N. Roy, S. K. Giri, H. R. Yadav, A. R. Choudhury and S. K. Guchhait, Chem. Commun., 2022, 58, 11827 DOI: 10.1039/D2CC04273H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements