Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance†
N. L.
Fletcher, 
*a
A.
Prior,
a
O.
Choy,
a
J.
Humphries,
a
P.
Huda,
a
S.
Ghosh,
a
Z. H.
Houston,
a
C. A.
Bell
a
and
K. J.
Thurecht
*a
*a
A.
Prior,
a
O.
Choy,
a
J.
Humphries,
a
P.
Huda,
a
S.
Ghosh,
a
Z. H.
Houston,
a
C. A.
Bell
a
and
K. J.
Thurecht
*a
Abstract
Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance of administered multifunctional branched PEGylated nanomedicines. The temporal influence of pre-targeting on polymer interaction with tumour cells and tissue is explored using in vitro assays through to preclinical validation.
- This article is part of the themed collections: Celebrating 10 years of ChemComm Emerging Investigators and Chemical Communications HOT Articles 2022
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