Issue 25, 2020

Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

Abstract

Nanoparticle-enhanced assays read by high-magnification dark-field microscopy require time-intensive analysis methods subject to selection bias, which can be resolved by using low magnification dark-field assays (LMDFA), at the cost of reduced sensitivity. We have simulated and experimentally validated a tunable linker-based signal amplification strategy yielding 6-fold enhanced LMDFA sensitivity.

Graphical abstract: Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

  • This article is part of the themed collection: Biosensors

Supplementary files

Article information

Article type
Communication
Submitted
08 பிப்ரவரி 2020
Accepted
19 மே 2020
First published
19 மே 2020

J. Mater. Chem. B, 2020,8, 5416-5419

Author version available

Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

D. Sun, L. Yang, C. J. Lyon and T. Hu, J. Mater. Chem. B, 2020, 8, 5416 DOI: 10.1039/D0TB00350F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements