We have engineered a hairpin ribozyme that in a two-step reaction supports RNA recombination by catalysing the cleavage of two non-functional RNA precursors (first step) followed by the recombination of two of the cleavage fragments into a functional RNA (second step). The recombination product (yield: 76%) is a fully functional hammerhead ribozyme.
R. Hieronymus, S. P. Godehard, D. Balke and S. Müller, Chem. Commun., 2016, 52, 4365 DOI: 10.1039/C6CC00383D
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