Issue 26, 2023

Functionalized ZnMnFe2O4–PEG–FA nanoenzymes integrating diagnosis and therapy for targeting hepatic carcinoma guided by multi-modality imaging

Abstract

With its insidious onset and atypical early symptoms, hepatic carcinoma is one of the most common and malignant tumors in the world. Therefore, it is necessary to actively pursue efficient diagnostic and treatment modalities for this malignancy. Photothermal therapy (PTT) is a non-invasive treatment technique that can generate high temperatures locally to induce tumor cell death, but its effectiveness is limited by the tissue-penetration depth of infrared light. Enzyme-catalyzed therapy promotes the production of toxic hydroxyl groups (˙OH) from hydrogen peroxide in tumor cells in situ, but its efficacy is also affected by the catalytic efficiency of ˙OH. Thus, given the complexity of tumors, multimodal therapy is critical for cancer treatment. Herein, we report a novel biomimetic nanoparticle (NP) platform (ZnMnFe2O4–PEG–FA) that enables combined PTT and nanozyme-catalyzed therapy. Due to the excellent photothermal effect of ZnMnFe2O4–PEG–FA, these NPs can reach an ideal temperature and damage tumor cells under lower near-infrared laser power irradiation, while exhibiting enhanced catalytic ability, largely alleviating the limitations of conventional PTT and catalytic therapy. Hence, the combination of these two treatments can provide significantly greater cytotoxicity. Additionally, ZnMnFe2O4–PEG–FA NPs have excellent photoacoustic imaging and magnetic resonance imaging capabilities, which enable monitoring and can guide cancer treatment. Therefore, ZnMnFe2O4–PEG–FA NPs integrate the diagnosis and treatment of tumors. Hence, this study provides a potential model of combined cancer diagnosis and treatment, which could be applied as a multimodal antitumor strategy in clinical settings in the future.

Graphical abstract: Functionalized ZnMnFe2O4–PEG–FA nanoenzymes integrating diagnosis and therapy for targeting hepatic carcinoma guided by multi-modality imaging

Supplementary files

Article information

Article type
Paper
Submitted
15 ஏப்ரல் 2023
Accepted
30 மே 2023
First published
01 ஜூன் 2023

Nanoscale, 2023,15, 11013-11025

Functionalized ZnMnFe2O4–PEG–FA nanoenzymes integrating diagnosis and therapy for targeting hepatic carcinoma guided by multi-modality imaging

J. Liu, X. Shi, Y. Qu and G. Wang, Nanoscale, 2023, 15, 11013 DOI: 10.1039/D3NR01746J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements