A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones†
Ayan
Acharya, 
‡a
Mithilesh
Nagpure,
‡a
Nibedita
Roy,
a
Santosh K.
Giri,
a
Angshuman
R. Choudhury
b
and
Sankar K.
Guchhait
*a
‡a
Mithilesh
Nagpure,
‡a
Nibedita
Roy,
a
Santosh K.
Giri,
a
Angshuman
R. Choudhury
b
and
Sankar K.
Guchhait
*a
Abstract
Herein, we report a Pd(0)-catalyzed cascade reaction of intramolecular indolyl isocyanide-insertion, isocyanide-initiated scaffold-rearrangement with indolyl migration and redox-neutral process, which affords an efficient access to indolylisoindolinones. Isocyanide as a C(sp3)H–N synthon and the alkyl motif of isocyanide as a hydride source have been explored for the first time.
- This article is part of the themed collection: 2022 CRSI Medal Winners Collection
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