Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)†
Qisi
Zhang, 
a
Cyrille S.
Kounde,
a
Milon
Mondal,
a
Jake L.
Greenfield,
a
Jennifer R.
Baker,
b
Sergei
Kotelnikov,
cd
Christopher P.
Tinworth,
e
Leran
Zhang,
a
Daniel
Conole,
a
Elena
De Vita,
a
Dima
Kozakov,
cd
Adam
McCluskey,
b
John D.
Harling,
e
Matthew J.
Fuchter
a
and
Edward W.
Tate
*a
a
Cyrille S.
Kounde,
a
Milon
Mondal,
a
Jake L.
Greenfield,
a
Jennifer R.
Baker,
b
Sergei
Kotelnikov,
cd
Christopher P.
Tinworth,
e
Leran
Zhang,
a
Daniel
Conole,
a
Elena
De Vita,
a
Dima
Kozakov,
cd
Adam
McCluskey,
b
John D.
Harling,
e
Matthew J.
Fuchter
a
and
Edward W.
Tate
*a
Abstract
Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
- This article is part of the themed collection: 2022 Pioneering Investigators
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