Enantioselective synthesis of triarylmethanes via organocatalytic transfer hydrogenation of para-quinone methides

Abstract

A new organocatalytic asymmetric method for the synthesis of enantioenriched triarylmethanes is developed. Different from the conventional approaches featuring asymmetric arylation, the present study employs asymmetric reduction via C–H bond formation as the key step. This approach does not require the presence of a heteroaryl ring or the presynthesis of unstable para-quinone methides. Instead, the stable racemic triarylmethanols were used as substrates for the in situ generation of the intermediates with a suitable chiral phosphoric acid catalyst.