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Issue 1, 2019
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A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

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Abstract

A simple route to enantiomerically pure (S)-2-aminobutyramide – the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

Graphical abstract: A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

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Article information


Submitted
26 அக்டோபர் 2018
Accepted
05 நவம்பர் 2018
First published
05 நவம்பர் 2018

Org. Biomol. Chem., 2019,17, 35-38
Article type
Communication

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

I. Baglai, M. Leeman, R. M. Kellogg and W. L. Noorduin, Org. Biomol. Chem., 2019, 17, 35
DOI: 10.1039/C8OB02660B

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