Issue 31, 2016

Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

Abstract

Proflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.

Graphical abstract: Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

  • This article is part of the themed collection: Foldamers

Supplementary files

Article information

Article type
Communication
Submitted
26 ஜனவரி 2016
Accepted
09 மார்ச் 2016
First published
09 மார்ச் 2016

Chem. Commun., 2016,52, 5436-5439

Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

B. J. Cafferty, C. Musetti, K. Kim, E. D. Horowitz, R. Krishnamurthy and N. V. Hud, Chem. Commun., 2016, 52, 5436 DOI: 10.1039/C6CC00779A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements