Issue 85, 2022

Protein phosphatase 1 regulates phosphorylation of gasdermin D and pyroptosis

Abstract

We report that phosphorylation of gasdermin D (GSDMD)-NT, cleaved by inflammatory caspases, could inhibit pyroptosis. Phosphatase 1 (PP1) is responsible for the regulation of GSDMD phosphorylation and the capacity of GSDMD to induce cell death. Our findings reveal a critical regulatory mechanism as it provides insight into pyroptosis processes.

Graphical abstract: Protein phosphatase 1 regulates phosphorylation of gasdermin D and pyroptosis

Supplementary files

Article information

Article type
Communication
Submitted
28 ஜூன் 2022
Accepted
29 செப்டம்பர் 2022
First published
30 செப்டம்பர் 2022

Chem. Commun., 2022,58, 11965-11968

Protein phosphatase 1 regulates phosphorylation of gasdermin D and pyroptosis

Y. Li, D. Pu, J. Huang, Y. Zhang and H. Yin, Chem. Commun., 2022, 58, 11965 DOI: 10.1039/D2CC03590A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements