Themed collection Most popular 2025 organic methodology articles

Electrochemical cleavage of C–N bonds has emerged as a sustainable alternative to traditional methods. This review highlights advances (2015–2025) in electrochemically driven radical deamination. functionalization.

An overview of C(sp²)–H and C(sp³)–H acetoxylation: from noble and base metal catalysis to cutting-edge electrochemical and photochemical strategies, unveiling sustainable pathways and mechanistic elegance.

Atom-economical trifluoromethylation of (hetero)arenes, including selected biomolecules, was achieved using a substoichiometric amount of a Cu(III) trifluoromethyl complex.

An unprecedented chemo-selective and multi-orthogonal SeNEx chemistry is reported as a powerful tool for programmable synthesis, on-plate nanomole-scale parallel synthesis and DNA-encoded library synthesis, thus accelerating functional discovery.

The first defluorinative sulfoximination and fluorosulfonylation of non-activated aryl fluorides at room temperature has been achieved.

An efficient copper-catalyzed carbonylative hydroallylation of vinylarenes has been developed using carbon monoxide as the C1 source.

Accelerated synthesis of heterocycles such as iminoboronates, boroxines, thiazolidines, and diazaborines using the reaction between boronic acid and amines in microdroplets.

Using ultrafast time-resolved IR spectroscopy, we find that charge-transfer excitation does not always localise on the strongest electron donor–acceptor pair. Solvation is another crucial factor which determines where the exciton is trapped.

Existing approaches to consider the synthesizability of generated molecules. This work demonstrates the use of an explicit retrosynthesis model directly as an optimization objective.

A multiligand-involved Cu catalysis offers an efficient Hiyama coupling of arylsilanes with unactivated alkyl halides, where copper with NHC and phenanthroline ligands were account for C(sp²)–Si activation and C(sp²)–C(sp³) formation, respectively.

A Ni-catalyzed cross-electrophile regioselective and site-divergent 1,2- and 1,3-arylalkylations of allylic amines has been developed, representing the first controllable migratory difunctionalization of alkenes under reductive conditions.

A new photocatalytic approach by using the assembly of DABCO A1 and B₂Nep₂B1 has been established to enable the cross-coupling of organohalides and alkenes for C(sp³)–C(sp³) bond formation.

Proton-coupled electron transfer (PCET) is a crucial chemical process involving the simultaneous or sequential transfer of protons and electrons, playing a vital role in biological processes and energy conversion technologies.

Nitriles stabilize neutral diarylboryl radicals, generating the RCN-BAr₂ complex, an efficient boron-nitrogen synthon that reacts with imines and olefins for photocatalytic synthesis of boron–nitrogen heterocycles, such as 1,4,2-diazaboroles.