Themed collection Nanoscale Most Popular 2025 Articles
Iron-based nanozymes induced ferroptosis for tumor therapy
This review highlights iron-based nanozymes including iron oxides, single-atom nanozymes, and MOFs that induce ferroptosis via ROS generation and Fenton chemistry, achieved by POD-, CAT-, OXD- and SOD-like activities.
Nanoscale, 2025,17, 14103-14117
https://doi.org/10.1039/D5NR00880H
Organic semiconductor bulk heterojunctions for solar-to-chemical conversion: recent advances and challenges
This minireview highlights recent progress in BHJ-based photoelectrochemical cells and photocatalysts for solar-to-chemical conversions.
Nanoscale, 2025,17, 1889-1921
https://doi.org/10.1039/D4NR03938F
Smart wearable fibers and textiles: status and prospects
Smart wearable fibers and textiles: status and prospects.
Nanoscale, 2025,17, 22733-22762
https://doi.org/10.1039/D5NR02801A
A review: metal and metal oxide nanoparticles for environmental applications
Environmental applications of metal and metal oxide nanoparticles primarily comprise contaminant adsorbents, catalysts, and sensors for hazardous substances, etc.
Nanoscale, 2025,17, 15068-15085
https://doi.org/10.1039/D5NR01973G
Metal–organic frameworks: a biomimetic odyssey in cancer theranostics
This review emphasizes the need for continued research into biomimetic MOFs for cancer theranostics, highlighting their potential to overcome current obstacles and provide safe, effective, and targeted therapeutic options. The graphical abstract was created in BioRender (www.biorender.com).
Nanoscale, 2025,17, 12620-12647
https://doi.org/10.1039/D5NR00794A
Advanced disease therapeutics using engineered living drug delivery systems
This review highlights how smart nanomaterials overcome biological barriers by enhancing targeting, reducing off-target effects, and enabling controlled drug release. Created in BioRender. Orash, A. (2025) https://BioRender.com/g97k271
Nanoscale, 2025,17, 7673-7696
https://doi.org/10.1039/D4NR05298F
Engineering the next generation of MXenes: challenges and strategies for scalable production and enhanced performance
Optimization strategy of MXene scale preparation.
Nanoscale, 2025,17, 6204-6265
https://doi.org/10.1039/D4NR04560B
Latest developments in the synthesis of metal–organic frameworks and their hybrids for hydrogen storage
Metal–organic frameworks (MOFs) are promising materials for hydrogen (H2) storage due to their versatile structures, high surface areas and substantial pore volumes.
Nanoscale, 2025,17, 6390-6413
https://doi.org/10.1039/D4NR03969F
Nanomaterial-enabled anti-biofilm strategies: new opportunities for treatment of bacterial infections
Scheme of nano-delivery systems in anti-biofilm application. Created with BioRender.com.
Nanoscale, 2025,17, 5605-5628
https://doi.org/10.1039/D4NR04774E
Bioactive surface-functionalized MXenes for biomedicine
This work reviews the surface modification strategies and biomedical applications of MXene, discusses the challenges, trends and prospects of MXenes nanomaterials, which provides information for enhancing the clinical translation of nanomedicine.
Nanoscale, 2025,17, 4854-4891
https://doi.org/10.1039/D4NR04260C
From synthesis to application: a review of BaZrS3 chalcogenide perovskites
This review covers BaZrS3 thin-film synthesis methods, optical, optoelectronic, electronic, and defect properties, and highlights device applications.
Nanoscale, 2025,17, 4250-4300
https://doi.org/10.1039/D4NR03880K
Recent advances in SERS assays for detection of multiple extracellular vesicles biomarkers for cancer diagnosis
This review provides insights on recent advances using label-free and label-based SERS assays for detecting multiple small extracellular vesicle biomarkers for cancer diagnosis, including issues surrounding their translation from lab to clinic.
Nanoscale, 2025,17, 3635-3655
https://doi.org/10.1039/D4NR04014G
Recent advances in biotin-based therapeutic agents for cancer therapy
Biotin binds to drugs in two main modes: SMBCs and NBCs. Tumor cells have more biotin receptors than normal cells, allowing for greater biotin uptake, which can enhance drug delivery to tumors.
Nanoscale, 2025,17, 1812-1873
https://doi.org/10.1039/D4NR03729D
Patterning technologies of quantum dots for color-conversion micro-LED display applications
A comprehensive summary of patterning technologies of quantum dots for construction of color-conversion layers in full-color micro-LED displays is provided.
Nanoscale, 2025,17, 1764-1789
https://doi.org/10.1039/D4NR03925D
Recent progress in two-dimensional Bi2O2Se and its heterostructures
Overview of the key aspects of 2D Bi2O2Se and representative schematic diagrams.
Nanoscale, 2025,17, 661-686
https://doi.org/10.1039/D4NR03769C
CeO2- and Mn3O4-based nanozymes exhibit scavenging of singlet oxygen species and hydroxyl radicals
Dex-CeO2 and Dex-Mn3O4 nanoparticles exhibit hydroxyl radical and singlet oxygen scavenging activities, with the potential to alleviate oxidative stress in mammalian systems.
Nanoscale, 2025,17, 18077-18082
https://doi.org/10.1039/D5NR00430F
Enhanced antifungal activity of siRNA-loaded anionic liposomes against the human pathogenic fungus Aspergillus fumigatus
Application of anionic liposomes co-loaded with amphotericin B and siRNA demonstrates a temporary antifungal effect lasting 3–4 days, highlighting their therapeutic potential.
Nanoscale, 2025,17, 7002-7007
https://doi.org/10.1039/D4NR03225J
Facile synthesis of magnetic core–shell structures for tunable microwave absorption
SnCo/C@MoS2 with core-shell structure had the RLmin of −64.27 dB, the EAB of 5.20 GHz and the RCS value below −20 dBm2, exhibiting remarkable microwave absorption properties.
Nanoscale, 2025,17, 18633-18645
https://doi.org/10.1039/D5NR01174D
A new computational approach for evaluating bending rigidity of graphene sheets incorporating disclinations
Two-dimensional (2D) materials exhibit remarkable flexibility and can be transformed into various shapes.
Nanoscale, 2025,17, 18112-18126
https://doi.org/10.1039/D5NR01102G
Electrochemical analysis of flexible symmetric supercapacitors using WSe2@graphite thin film electrodes under different pH conditions
A key focus of this research is to investigate the influence of electrolyte pH on the supercapacitive performance of a flexible symmetric supercapacitor (SS) based on WSe2@graphite composite electrodes.
Nanoscale, 2025,17, 16457-16475
https://doi.org/10.1039/D5NR01328C
Activated carbon derived from shrimp waste enhanced by ball milling: a green solution for CO2 capture and waste valorization
Shrimp waste-derived biochar (BC), pretreated with HCl, was chemically activated with KOH at varying mass ratios and subjected to ball milling to engineer high-performance CO2 adsorbents.
Nanoscale, 2025,17, 14696-14708
https://doi.org/10.1039/D5NR00725A
Magnetically driven lipid vesicles for directed motion and light-triggered cargo release
Systematic investigation of lipid vesicles propelled by encapsulated magnetic particles via an inhomogeneous magnetic field, enabling navigational control and remotely triggered drug release for targeted delivery and precision medicine applications.
Nanoscale, 2025,17, 13720-13726
https://doi.org/10.1039/D5NR00942A
PEGylated lipid screening, composition optimization, and structure–activity relationship determination for lipid nanoparticle-mediated mRNA delivery
Screening PEG-lipids and optimizing lipid nanoparticle (LNP) composition for intramuscular mRNA delivery. Advanced characterization of LNPs elucidates the structure–activity relationship and identifies key LNP attributes for in vivo transfection.
Nanoscale, 2025,17, 11329-11344
https://doi.org/10.1039/D5NR00433K
Spectroscopic evidence of intra-unit-cell charge redistribution in a charge-neutral magnetic topological insulator
Intra-unit-cell charge imbalance in the charge-neutral Sb-doped MnBi6Te10 crystal leads to a nanoscale p–n junction, resulting in the multiple surface photovoltage effects at the boundaries of crystal domains in time-resolved ARPES measurements.
Nanoscale, 2025,17, 10663-10669
https://doi.org/10.1039/D4NR04812A
A nanoscale chemical oscillator: reversible formation of palladium nanoparticles in ionic liquid
During transmission electron microscopy imaging, nanoparticles display cyclic behaviour resembling that of living organisms: birth, growth, and decay, followed by the next generation of nanoparticles repeating the cycle.
Nanoscale, 2025,17, 10105-10116
https://doi.org/10.1039/D4NR04150J
Combined effects of electrode morphology and electrolyte composition on single H2 gas bubble detachment during hydrogen evolution reaction
Depending on the direction of the Marangoni effects, gas bubble locations and consequently the force balance determining gas bubble detachment can vary significantly.
Nanoscale, 2025,17, 10020-10034
https://doi.org/10.1039/D5NR00234F
A comparative study of bulk and surface W-doped high-Ni cathode materials for lithium-ion batteries
This study examines tungsten (W) doping in NCM811 cathodes via bulk (co-precipitation) and surface (solid-state) methods. W doping enhances charge transfer and stabilizes structure, reducing capacity fade (retain 92% capacity after 500 cycles).
Nanoscale, 2025,17, 8192-8205
https://doi.org/10.1039/D4NR04691A
Functionalized graphitic carbon nitride as an efficient electro-analytical platform for the label-free electrochemical sensing of interleukin-8 in saliva samples
An illustrative diagram outlining the sequential process of creating an immunoassay platform to detect the IL8 biomarker in saliva samples utilizing g-C3N4 as the foundation.
Nanoscale, 2025,17, 7926-7944
https://doi.org/10.1039/D4NR02039A
What makes β-NaYF4:Er3+,Yb3+ such a successful luminescent thermometer?
The upconversion phosphor β-NaYF4:Er3+,Yb3+ is one of the primary working horse examples for ratiometric luminescent Boltzmann thermometry. But why? Theoretical arguments are used in this work to unravel that recorded success.
Nanoscale, 2025,17, 7091-7099
https://doi.org/10.1039/D4NR04392H
Simultaneous pore confinement and sidewall modification of an N-rich COF with Pd(II): an efficient and sustainable heterogeneous catalyst for cross-coupling reactions
A Palladium-supported covalent organic framework (COF) designed for efficient C–C cross-coupling reactions with good stability and recyclability.
Nanoscale, 2025,17, 4765-4775
https://doi.org/10.1039/D4NR03796K
Enhanced detection of Brain-Derived Neurotrophic Factor (BDNF) using a reduced graphene oxide field-effect transistor aptasensor
Neurodegenerative diseases, characterized by the progressive deterioration of neuronal function and structure, pose significant global public health and economic challenges.
Nanoscale, 2025,17, 4543-4555
https://doi.org/10.1039/D4NR04228J
Eco-friendly synthesis of a porous reduced graphene oxide–polypyrrole–gold nanoparticle hybrid nanocomposite for electrochemical detection of methotrexate using a strip sensor
Chemotherapy is a crucial cancer treatment, but its effectiveness requires precise monitoring of drug concentrations in patients.
Nanoscale, 2025,17, 4472-4484
https://doi.org/10.1039/D4NR04010D
Oral delivery of MOMIPP lipid nanoparticles for methuosis-induced cancer chemotherapy
MOMIPP-SEDDS increased the relative bioavailability by 19.98-fold and achieved favorable tumor inhibition. Clear evidence of methuosis in the tumor tissue following MOMIPP-SEDDS treatment was revealed by TEM imaging.
Nanoscale, 2025,17, 4082-4098
https://doi.org/10.1039/D4NR04044A
Strain-tunable optoelectronic and photocatalytic properties of 2D GaN/MoSi2P4 heterobilayers: potential optoelectronic/photocatalytic materials
Biaxial tensile strain can induce type-II band alignment with the Z-scheme in a GaN/MoSi2P4 heterobilayer, indicating potential applications in optoelectronic and photocatalytic devices.
Nanoscale, 2025,17, 3900-3909
https://doi.org/10.1039/D4NR04545A
Theoretical insights into spacer molecule design to tune stability, dielectric, and exciton properties in 2D perovskites
We investigate how spacer molecules influence the properties of RP-type 2D perovskites. Modifying aromatic units (PMA, THMA, FUMA) reveals that small adjustments can significantly affect dielectric screening, exciton binding energy, and structure.
Nanoscale, 2025,17, 2658-2667
https://doi.org/10.1039/D4NR04406A
Ultrasensitive non-enzymatic electrochemical detection of paraoxon-ethyl in fruit samples using 2D Ti3C2Tx/MWCNT-OH
A highly sensitive non-enzymatic electrochemical sensor using a Ti3C2Tx/MWCNT-OH nanocomposite detects paraoxon-ethyl in fruit with high selectivity, a 0.1–100 μM range, and a 10 nM LOD, offering a sustainable alternative for pesticide monitoring.
Nanoscale, 2025,17, 2554-2566
https://doi.org/10.1039/D4NR04060K
Rational design of NiCo2O4@carbon hollow spheres as a high-performance electrode material for flexible supercapacitors
The unique hollow morphology of NiCo2O4, combined with a uniform carbon coating, provides exceptional ion accessibility and electron transport.
Nanoscale, 2025,17, 2252-2258
https://doi.org/10.1039/D4NR04709E
Sustainable and energy-saving hydrogen production via binder-free and in situ electrodeposited Ni–Mn–S nanowires on Ni–Cu 3-D substrates
A bi-functional electrocatalyst based on Ni–Mn–S nanowires@Ni–Cu micro–nano dendrites was designed for the HER and UOR, which demonstrated favorable catalytic activity and stability for energy-saving hydrogen production.
Nanoscale, 2025,17, 2162-2173
https://doi.org/10.1039/D4NR03486D
Construction of a circularly polarized luminescence sensor based on self-assembly of carbon dots and G-quartet chiral nanofibers
This study develops a highly sensitive chiroptical sensor for detecting Hg2+ and I− ions through the co-assembly of G-quartet nanofibers and N–S-CDs.
Nanoscale, 2025,17, 1342-1349
https://doi.org/10.1039/D4NR03178D
Machine learning-guided discovery of gas evolving electrode bubble inactivation
Experimental interrogation unveils that as much as 75% of the area underneath bubbles is electrochemically active. A simple method for estimating the degree of electrode inactivation due to bubbles is demonstrated.
Nanoscale, 2025,17, 1270-1281
https://doi.org/10.1039/D4NR02628D
Biodegradable cellulose nanocrystal composites doped with carbon dots for packaging and anticounterfeiting applications
This work focuses on water-based carbon dots and CNCs from Vigna mungo, used in anti-counterfeit inks and sensor films. These CDs are UV-visible, pH-sensitive, antimicrobial, and biodegradable, offering multifunctional packaging solutions.
Nanoscale, 2025,17, 904-918
https://doi.org/10.1039/D4NR03768E
About this collection
Showcasing some of the most cited and most accessed articles published in Nanoscale during 2025.
Congratulations to all of the authors whose articles have been featured!