A straightforward protocol for the synthesis of 3-fluoroallyl alcohols via fluorine-hydrogen bonding promoted gold catalyzed hydrofluorination using Et3N·3HF under acidic additive-free conditions has been developed.
The hydrofluorination of enynoates has been developed for the synthesis of fluorinated dienoates.
We disclose a method for the net coupling of nucleophiles with a single fluorine of unactivated (trifluoromethyl)alkanes.
A gold-catalyzed hydrofluorination of terminal alkynes using potassium bifluoride (KHF2) as a cheaper, safer, and water-free fluoride source, is reported.
A process to shuttle HF from a fluoroalkane to alkynes has been developed. The consecutive dehydrofluorination and hydrofluorination steps are catalysed by an amorphous zirconium chlorofluoride at room temperature.