Recent advancements in research on halogen atom transfer (XAT)-driven carbon radical chemistry for organohalides from the perspective of various relayed radicals such as aryl, alkyl, silyl, and boryl radicals are discussed.
Efficient photooxidation of amines by visible-light-responsive metal–organic frameworks generating α-aminoalkyl radicals to achieve halogen-atom transfer (XAT) reactions of dehalogenation, hydroalkylation and polyfluoroarylation.
A DFT study of Lb–BH2+-mediated C–I activation, Lb–BH2˙-facilitated XAT and alkyl radical generation, and [Cu(II)]-mediated C–N bond formation through combined one-electron oxidation and two-electron reduction.
A new class of bench-stable zinc dithiolates as thiolating reagents have been developed for XAT-mediated radical functionalization of various alkyl iodides at room temperature.
The Sonogashira-like alkynylation of alkyl halides is achieved by a photocatalytic approach exploiting amine-ligated boryl radicals as halogen-atom transfer mediators in combination with alkynyl sulfones as SOMOphilic reagents.