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Radical-mediated oxidative annulations of 1,n-enynes involving C–H functionalization
Yang Li, Gao-Ang Pan, Mu-Jia Luo and Jin-Heng Li
Chem. Commun., 2020, 56, 6907
DOI: 10.1039/D0CC02335C

Visible-light–induced regioselective chalcogenation of indoloquinoxalines via cross-dehydrogenative coupling under metal-free, open-air conditions
Biman Bera, Rahul Dutta, Shubhankar Ghorai, Jhuma Ganguly and Mrinal K. Bera
Org. Biomol. Chem., 2025, 23, 8695
DOI: 10.1039/D5OB01088H

Transition-metal-catalyzed alkene-relayed intermolecular C–H activation
Qiongqiong Zhu, Ming-Shun Mei, Xiang Zuo and Yanghui Zhang
Chem. Commun., 2025, 61, 11921
DOI: 10.1039/D5CC02983J

Remote C(sp3)–H functionalizationviacatalytic cyclometallation: beyond five-membered ring metallacycle intermediates
Mario Martínez Mingo, Nuria Rodríguez, Ramón Gómez Arrayás and Juan C. Carretero
Org. Chem. Front., 2021, 8, 4914
DOI: 10.1039/D1QO00389E

Tertiary amine-directed and involved carbonylative cyclizations through Pd/Cu-cocatalyzed multiple C–X (X = H or N) bond cleavage
Qiu-Chao Mu, Yi-Xue Nie, Xing-Feng Bai, Jing Chen, Lei Yang, Zheng Xu, Li Li, Chun-Gu Xia and Li-Wen Xu
Chem. Sci., 2019, 10, 9292
DOI: 10.1039/C9SC03081F

Continuous-flow directed C–H amidation reactions using immobilized Cp*Rh(iii) catalysts
Yuki Saito, Taro Konno and Shū Kobayashi
Green Chem., 2024, 26, 8680
DOI: 10.1039/D4GC01747A

An unusual four-step cascade reaction for accessing furo[3,4-c]pyridine-1,4-dionesviarhodium catalysis
Yidi Li, Huiying Xu, Zhi Zhou, Lin Huang, Zhenhao Tang, Wei Yi and Xiaowei Wu
Org. Chem. Front., 2023, 10, 4658
DOI: 10.1039/D3QO00909B

Ruthenium-catalysed late-stage C–H alkynylation of carboxylic acids using sustainable deep eutectic solvents
Julia Wtulich, Ian A. Nicholls and Subban Kathiravan
New J. Chem., 2025, 49, 6666
DOI: 10.1039/D5NJ00359H

Synthesis of 1,2-dihydro-1,3,5-triazine derivatives via Cu(ii)-catalyzed C(sp3)–H activation of N,N-dimethylethanolamine with amidines
Min Yan, Renchao Ma, Rener Chen, Lei Wang, Zhiming Wang and Yongmin Ma
Chem. Commun., 2020, 56, 10946
DOI: 10.1039/D0CC03820B

Guggulsterone – a potent bioactive phytosteroid: synthesis, structural modification, and its improved bioactivities
T. P. Adarsh Krishna, T. P. Ajeesh Krishna, Baldev Edachery and S. Antony Ceasar
RSC Med. Chem., 2024, 15, 55
DOI: 10.1039/D3MD00432E

Recent advances and perspectives in manganese-catalyzed C–H activation
Thaipparambil Aneeja, Mohan Neetha, C. M. A. Afsina and Gopinathan Anilkumar
Catal. Sci. Technol., 2021, 11, 444
DOI: 10.1039/D0CY02087G

Transition-metal catalyzed C–H activation as a means of synthesizing complex natural products
Soumya Kumar Sinha, Pintu Ghosh, Shubhanshu Jain, Siddhartha Maiti, Shaeel A. Al-Thabati, Abdulmohsen Ali Alshehri, Mohamed Mokhtar and Debabrata Maiti
Chem. Soc. Rev., 2023, 52, 7461
DOI: 10.1039/D3CS00282A

Isoxazole as a nitrile synthon: en routes to the ortho-alkenylated isoxazole and benzonitrile with allyl sulfone catalyzed by Ru(ii)
Pritishree Panigrahi, Subhendu Ghosh, Tamanna Khandelia, Raju Mandal and Bhisma K. Patel
Chem. Commun., 2023, 59, 10536
DOI: 10.1039/D3CC02996D

Asymmetric formal synthesis of (−)-tetrazomine
Wei-Yi Qi, Sheng-Long Fang, Xue-Tao Xu, Kun Zhang and Bing-Feng Shi
Org. Chem. Front., 2021, 8, 1802
DOI: 10.1039/D1QO00029B

C(sp2)–H functionalization in non-aromatic azomethine-based heterocycles
Alexey A. Akulov, Mikhail V. Varaksin, Pieter Mampuys, Valery N. Charushin, Oleg N. Chupakhin and Bert U. W. Maes
Org. Biomol. Chem., 2021, 19, 297
DOI: 10.1039/D0OB01580F

Insights into the mechanism of 3d transition-metal-catalyzed directed C(sp3)–H bond functionalization reactions
Andrés García-Viada, Juan C. Carretero, Javier Adrio and Nuria Rodríguez
Chem. Soc. Rev., 2025, 54, 4353
DOI: 10.1039/D4CS00657G

Ruthenium(ii)-catalysed selective C(sp2)–H bond benzoxylation of biologically appealing N-arylisoindolinones
Yu-Chao Yuan, Christian Bruneau, Thierry Roisnel and Rafael Gramage-Doria
Org. Biomol. Chem., 2019, 17, 7517
DOI: 10.1039/C9OB01122F

One reaction – double stereoinduction: C–H activation as a privileged route towards complex atropisomeric molecules
Amandine Luc and Joanna Wencel-Delord
Chem. Commun., 2023, 59, 8159
DOI: 10.1039/D3CC01328F

O-Directed C–H functionalization via cobaltacycles: a sustainable approach for C–C and C–heteroatom bond formations
Shyam Kumar Banjare, Tanmayee Nanda, Bedadyuti Vedvyas Pati, Pragati Biswal and Ponneri Chandrababu Ravikumar
Chem. Commun., 2021, 57, 3630
DOI: 10.1039/D0CC08199J

C–H functionalization of quinazolinones by transition metal catalysis
Prasanjit Ghosh, Bhaskar Ganguly and Sajal Das
Org. Biomol. Chem., 2020, 18, 4497
DOI: 10.1039/D0OB00742K

Formal allylic C(sp3)–H alkylation of α-alkylstyrenes by rearrangement of intermediate alkenyl sulfonium salts
Zeyu Shao, Junqi Zhou, Ziyu Wang, Biao Liu, Liang-Hua Zou, Cheng Wang and Jian Wen
Org. Chem. Front., 2023, 10, 3275
DOI: 10.1039/D3QO00459G

Synthesis of tryptophan-containing 2,5-diketopiperazines via sequential C–H activation: total syntheses of tryprostatin A, maremycins A and B
Xue-Song Yin, Wei-Yi Qi and Bing-Feng Shi
Chem. Sci., 2021, 12, 13137
DOI: 10.1039/D1SC02343H

Transition metal catalysed direct selanylation of arenes and heteroarenes
Daniel S. Rampon, Eduardo Q. Luz, David B. Lima, Renata A. Balaguez, Paulo Henrique Schneider and Diego Alves
Dalton Trans., 2019, 48, 9851
DOI: 10.1039/C9DT00473D

Visible-light-mediated site-selective C(sp2)–H alkylation of tropones facilitates semi-synthesis of cephafortunoids A and B
Qi-Xiang Zeng, Cheng-Yu Zheng, Zhan-Peng Ge, Jin-Xin Zhao and Jian-Min Yue
Chem. Sci., 2025, 16, 8836
DOI: 10.1039/D5SC01006C

Palladium-catalyzed synthesis of β-hydroxy compounds via a strained 6,4-palladacycle from directed C–H activation of anilines and C–O insertion of epoxides
Raju S. Thombal, Taisiia Feoktistova, Gisela A. González-Montiel, Paul H.-Y. Cheong and Yong Rok Lee
Chem. Sci., 2020, 11, 7260
DOI: 10.1039/D0SC01462A

A visible-light-induced cascade cyclization strategy for the synthesis of N,S-containing polycyclic compounds
Shichao Yang, Ruihua Zhao, Dan Liu, Huanfeng Jiang, Gui-Juan Cheng and Wanqing Wu
Org. Chem. Front., 2024, 11, 5067
DOI: 10.1039/D4QO00683F

Iron-catalysed alkene and heteroarene H/D exchange by reversible protonation of iron-hydride intermediates
Luke Britton, Jamie H. Docherty, Jan Sklyaruk, Jessica Cooney, Gary S. Nichol, Andrew P. Dominey and Stephen P. Thomas
Chem. Sci., 2022, 13, 10291
DOI: 10.1039/D2SC03802A

Multifaceted photocatalysis enables cobalt catalyzed enantioselective C–H activation and APEX reaction for C–N axially chiral molecules
Mainak Koner, Nityananda Ballav, Anirudh J. Varma, Suman Ghosh, Tuhin Mondal, Rositha Kuniyil and Mahiuddin Baidya
Chem. Sci., 2025
DOI: 10.1039/D5SC05287D

Access to distal meta-C–H functionalization of arylmethanesulfonic acid derivatives
Dasari Srinivas, Kurella Mounika and Gedu Satyanarayana
Chem. Commun., 2023, 59, 9106
DOI: 10.1039/D3CC02260A

C(sp3)–H Ritter amination by excitation of in situ generated iodine(iii)–BF3 complexes
Rok Narobe, Kathiravan Murugesan, Christoph Haag, Tobias Emanuel Schirmer and Burkhard König
Chem. Commun., 2022, 58, 8778
DOI: 10.1039/D2CC03283J

C–H deuteration of organic compounds and potential drug candidates
Gaurav Prakash, Nilanjan Paul, Gwyndaf A. Oliver, Daniel B. Werz and Debabrata Maiti
Chem. Soc. Rev., 2022, 51, 3123
DOI: 10.1039/D0CS01496F

Traceless directing groups: a novel strategy in regiodivergent C–H functionalization
Geetika Rani, Vijay Luxami and Kamaldeep Paul
Chem. Commun., 2020, 56, 12479
DOI: 10.1039/D0CC04863A

Photoinduced iodine-mediated tandem dehydrogenative Povarov cyclisation/C–H oxygenation reactions
Eva Schendera, Alexander Villinger and Malte Brasholz
Org. Biomol. Chem., 2020, 18, 6912
DOI: 10.1039/D0OB01494J

Pd-Catalyzed and ligand-enabled alkene difunctionalization via unactivated C–H bond functionalization
Balaji D. Barve, Yao-Haur Kuo and Wen-Tai Li
Chem. Commun., 2021, 57, 12045
DOI: 10.1039/D1CC04397H

Access to benzene-modified 2nd generation strigolactams and GR24 by merging C–H olefination with decarboxylative Giese cyclization
Yuhua Ge, Xingyue Chen, Yi Dong, Hua-Nan Wang, Yangyan Li and Gang Chen
Org. Biomol. Chem., 2021, 19, 7141
DOI: 10.1039/D1OB01234G

Multiple annulations of inert C(sp2)–H bonds with alkynes
Arijit Saha, Majji Shankar, Somratan Sau and Akhila K. Sahoo
Chem. Commun., 2022, 58, 4561
DOI: 10.1039/D2CC00172A

Transition metal-catalyzed C–H/C–C activation and coupling with 1,3-diyne
Bedadyuti Vedvyas Pati, Nitha Nahan Puthalath, Shyam Kumar Banjare, Tanmayee Nanda and Ponneri C. Ravikumar
Org. Biomol. Chem., 2023, 21, 2842
DOI: 10.1039/D3OB00238A

K2S2O8 activation by glucose at room temperature for the synthesis and functionalization of heterocycles in water
Joydev K. Laha and Mandeep Kaur Hunjan
Chem. Commun., 2021, 57, 8437
DOI: 10.1039/D1CC03777C

Direct C–H difluoroallylation of α,β-unsaturated amides and aryl amides by rhodium catalysis
Wenqian Ding, Wanqi Hu, Xingyu Chen, Yan Wang, Xueqing Liu, Weiqi Liu and Xiaowei Wu
Chem. Commun., 2024, 60, 13036
DOI: 10.1039/D4CC03804E

Experimental and theoretical studies of the rhodium(i)-catalysed C–H oxidative alkenylation/cyclization ofN-(2-(methylthio)phenyl)benzamides with maleimides
Aymen Skhiri, Attila Taborosi, Nozomi Ohara, Yusuke Ano, Seiji Mori and Naoto Chatani
Org. Chem. Front., 2023, 10, 1617
DOI: 10.1039/D3QO00023K

Insight into the mechanism of the arylation of arenes via norbornene relay palladation through meta- to para-selectivity
Shengnan Liu, Qiong Wang, Fang Huang, Wenjuan Wang, Chong Yang, Jianbiao Liu and Dezhan Chen
Org. Chem. Front., 2022, 9, 129
DOI: 10.1039/D1QO01500A

Rhodium-catalyzed enone carbonyl directed C–H activation for the synthesis of indanones containing all-carbon quaternary centers
Jiang Lou, Wenjia Han, Zhuqing Liu and Jiaqi Xiao
Org. Chem. Front., 2021, 8, 1447
DOI: 10.1039/D1QO00056J

Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity
Zhen Zhang, Sneha Ray, Leah Imlay, Lauren T. Callaghan, Hanspeter Niederstrasser, Prema Latha Mallipeddi, Bruce A. Posner, Dawn M. Wetzel, Margaret A. Phillips and Myles W. Smith
Chem. Sci., 2021, 12, 10388
DOI: 10.1039/D1SC02838C

Heteroarylation of unactivated C–H bonds suitable for late-stage functionalization
Austin S. Miller and Erik J. Alexanian
Chem. Sci., 2022, 13, 11878
DOI: 10.1039/D2SC04605A

Iron-catalyzed carboamination of vinylarenes with alkanes and nitrogen nucleophiles
Fengxiang Zhu and Jianxin Xue
Org. Chem. Front., 2024, 11, 1742
DOI: 10.1039/D3QO01934A

Iridium-catalyzed regioselective C–H sulfonamidation of 1,2,4-thiadiazoles with sulfonyl azides in water
Xian-Ting Cao, Su-Ning Wei, Hao-Tian Sun, Meng Li, Zuo-Ling Zheng and Guannan Wang
RSC Adv., 2021, 11, 22000
DOI: 10.1039/D1RA04450H

Photolysis of Tp′Rh(CNneopentyl)(PhNCNneopentyl) in the presence of ketones and esters: kinetic and thermodynamic selectivity for activation of different aliphatic C–H bonds
Astrid M. Parsons and William D. Jones
Dalton Trans., 2019, 48, 10945
DOI: 10.1039/C9DT01802F

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Bhargav Desai, Ajay Uppuluru, Ashutosh Dey, Neha Deshpande, Bharatkumar Z. Dholakiya, Akella Sivaramakrishna, Togati Naveen and Kishor Padala
Org. Biomol. Chem., 2023, 21, 673
DOI: 10.1039/D2OB01936A

Rh(iii)-catalyzed selective mono- and dual-functionalization/cyclization of 1-aryl-5-aminopyrazoles with iodonium ylides
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu and Jiuzhong Huang
Chem. Commun., 2024, 60, 432
DOI: 10.1039/D3CC05266D

Palladium-catalyzed remote meta-C–H olefination of cinnamates
Manickam Bakthadoss, Mir Ashiq Hussain and Tadiparthi Thirupathi Reddy
Chem. Commun., 2023, 59, 5249
DOI: 10.1039/D3CC00289F

A three component 1,3-difunctionalization of vinyl diazo esters enabled by a cobalt catalyzed C–H activation/carbene migratory insertion
Nandkishor Prakash Khot, Prajyot Jayadev Nagtilak, Nitish Kumar Deo and Manmohan Kapur
Chem. Commun., 2023, 59, 6076
DOI: 10.1039/D3CC00295K

Double annulation of ortho- and peri-C–H bonds of fused (hetero)arenes to unusual oxepino-pyridines
Majji Shankar, Raja K. Rit, Somratan Sau, Kallol Mukherjee, Vincent Gandon and Akhila K. Sahoo
Chem. Sci., 2020, 11, 10770
DOI: 10.1039/D0SC01373K

Conceptual advances in nucleophilic organophosphine-promoted transformations
Lona Dutta, Atanu Mondal, Jay Prakash Maurya, Dipto Mukhopadhyay and S. S. V. Ramasastry
Chem. Commun., 2023, 59, 11045
DOI: 10.1039/D3CC03648K

Electronic control over site-selectivity in hydrogen atom transfer (HAT) based C(sp3)–H functionalization promoted by electrophilic reagents
Marco Galeotti, Michela Salamone and Massimo Bietti
Chem. Soc. Rev., 2022, 51, 2171
DOI: 10.1039/D1CS00556A

Directing group assisted rhodium catalyzed meta-C–H alkynylation of arenes
Sheuli Sasmal, Gaurav Prakash, Uttam Dutta, Ranjini Laskar, Goutam Kumar Lahiri and Debabrata Maiti
Chem. Sci., 2022, 13, 5616
DOI: 10.1039/D2SC00982J

Easy access to drug building-blocks through benzylic C–H functionalization of phenolic ethers by photoredox catalysis
Tobias Brandhofer, Martin Stinglhamer, Volker Derdau, María Méndez, Christoph Pöverlein and Olga García Mancheño
Chem. Commun., 2021, 57, 6756
DOI: 10.1039/D1CC01756J

Cobalt-catalyzed regio- and stereoselective synthesis of atropisomers with vicinal C–C and C–N diaxes
Suman Ghosh, Partha Sarathi Saha, Shib Nath Saha, Sanoop P. Chandrasekharan, Mainak Koner and Mahiuddin Baidya
Chem. Commun., 2025, 61, 15231
DOI: 10.1039/D5CC04297F

Progress in copper-catalysed/mediated intramolecular dehydrogenative coupling
Rasmi P. Bhaskaran, Kalinga H. Nayak, Mariswamy K. Sreelekha and Beneesh P. Babu
Org. Biomol. Chem., 2023, 21, 237
DOI: 10.1039/D2OB01796B

Visible light promoted cross-dehydrogenative coupling: a decade update
Avik Kumar Bagdi, Matiur Rahman, Dhananjay Bhattacherjee, Grigory V. Zyryanov, Sumit Ghosh, Oleg N. Chupakhin and Alakananda Hajra
Green Chem., 2020, 22, 6632
DOI: 10.1039/D0GC02437F

Remote ortho-C–H functionalization via medium-sized cyclopalladation
Mario Martínez Mingo, Nuria Rodríguez, Ramón Gómez Arrayás and Juan C. Carretero
Chem. Commun., 2022, 58, 2034
DOI: 10.1039/D1CC05310H

Recent advances in intramolecular C–O/C–N/C–S bond formationviaC–H functionalization
Paran J. Borpatra, Bhaskar Deka, Mohit L. Deb and Pranjal K. Baruah
Org. Chem. Front., 2019, 6, 3445
DOI: 10.1039/C9QO00863B

Ru(ii)/Ru(iv)-catalyzed C(sp2)–H allylation with alkene difunctionalization to access isochroman-1-imines
Ashish Joshi, Shruti Moorthy, Lilesh Rambhai Chavada, Saurabh Kumar Singh and Ashok Kumar Pandey
Chem. Commun., 2023, 59, 9497
DOI: 10.1039/D3CC01604H

Rhodium(iii)-catalyzed chemoselective C–H functionalization of benzamides with methyleneoxetanones controlled by the solvent
Mengyao Bian, Kuangshun Ma, Hamdulla Mawjuda, Xiyong Yu, Xingwei Li, Hui Gao, Zhi Zhou and Wei Yi
Org. Biomol. Chem., 2019, 17, 6114
DOI: 10.1039/C9OB00645A

Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds
Praveen P. Singh, Pravin K. Singh and Vishal Srivastava
Org. Chem. Front., 2023, 10, 216
DOI: 10.1039/D2QO01582J

Transition metal-catalyzed cascade C–H activation/cyclization with alkynes: an update on sulfur-containing directing groups
Fen Xu, Shi-Yu Zhang, Ya-Peng Li, Jia-Qi Huo and Fan-Wang Zeng
Chem. Commun., 2025, 61, 1729
DOI: 10.1039/D4CC05807K

Late stage C–H functionalization via chalcogen and pnictogen salts
Christopher B. Kelly and Rosaura Padilla-Salinas
Chem. Sci., 2020, 11, 10047
DOI: 10.1039/D0SC03833D

Recent advances in Rh(i)-catalyzed enantioselective C–H functionalization
Yue Zhang, Jing-Jing Zhang, Lujun Lou, Ruofan Lin, Nicolai Cramer, Shou-Guo Wang and Zhen Chen
Chem. Soc. Rev., 2024, 53, 3457
DOI: 10.1039/D3CS00762F

Pd-catalyzed regioselective activation of C(sp2)–H and C(sp3)–H bonds
Wajid Ali, Gwyndaf A. Oliver, Daniel B. Werz and Debabrata Maiti
Chem. Soc. Rev., 2024, 53, 9904
DOI: 10.1039/D4CS00408F

Salient features of the aza-Wacker cyclization reaction
Annu Anna Thomas, Someshwar Nagamalla and Shyam Sathyamoorthi
Chem. Sci., 2020, 11, 8073
DOI: 10.1039/D0SC02554B

Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification
Xiaoyan Hou, Nikolaos Kaplaneris, Binbin Yuan, Johanna Frey, Tsuyoshi Ohyama, Antonis M. Messinis and Lutz Ackermann
Chem. Sci., 2022, 13, 3461
DOI: 10.1039/D1SC07267F

C–H modification of natural products: a minimalist enabling tactic for drug discovery, API processing and bioconjugation
Saumitra Sengupta, Srihari Pabbaraja and Goverdhan Mehta
Chem. Commun., 2023, 59, 9445
DOI: 10.1039/D3CC01644G

Selective preparative ‘oxidase phase’ in sesquiterpenoids: the radical approach
Maria Kourgiantaki, Georgia G. Bagkavou, Christos I. Stathakis and Alexandros L. Zografos
Org. Chem. Front., 2023, 10, 2095
DOI: 10.1039/D3QO00314K

Multiple activations of CH bonds in arenes and heteroarenes
Richard D. Adams and Poonam Dhull
Dalton Trans., 2019, 48, 8530
DOI: 10.1039/C9DT01584A

Rh(iii)-Catalyzed olefination to build diverse oxazole derivatives from functional alkynes
Yuan He, Ting Zheng, Yin-Hui Huang and Lin Dong
Org. Biomol. Chem., 2021, 19, 4937
DOI: 10.1039/D1OB00507C

Reframing primary alkyl amines as aliphatic building blocks
Kathleen J. Berger and Mark D. Levin
Org. Biomol. Chem., 2021, 19, 11
DOI: 10.1039/D0OB01807D

Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
Subban Kathiravan, Tianshu Zhang and Ian A. Nicholls
RSC Adv., 2023, 13, 11291
DOI: 10.1039/D3RA02031B

Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone
Renzhi Chen, Sihan Yang and Yandong Zhang
Org. Biomol. Chem., 2020, 18, 1036
DOI: 10.1039/C9OB02642H

Ruthenium-catalyzed (spiro)annulation of N-aryl-2,3-dihydrophthalazine-1,4-diones with quinones to access pentacyclic spiro-indazolones and fused-cinnolines
Sushma Naharwal, Pidiyara Karishma, Chikkagundagal K. Mahesha, Kiran Bajaj, Sanjay K. Mandal and Rajeev Sakhuja
Org. Biomol. Chem., 2022, 20, 4753
DOI: 10.1039/D2OB00493C

Zinc catalysed electrophilic C–H borylation of heteroarenes
Matthew E. Grundy, Kang Yuan, Gary S. Nichol and Michael J. Ingleson
Chem. Sci., 2021, 12, 8190
DOI: 10.1039/D1SC01883C

Merging Cu-catalysed C–H functionalisation and intramolecular annulations: computational and experimental studies on an expedient construction of complex fused heterocycles
Timothy L. Wootton, Jack A. Porter, Karmjit S. Grewal, Paula G. Chirila, Sarah Forbes, Simon J. Coles, Peter N. Horton, Alex Hamilton and Christopher J. Whiteoak
Org. Chem. Front., 2020, 7, 1235
DOI: 10.1039/D0QO00283F

Metal-free oxoammonium salt-mediated C(sp3)–H oxidative Ugi-azide multicomponent reaction
Niklas Lohmann, Vesna Milovanović, Dariusz G. Piekarski and Olga García Mancheño
Org. Biomol. Chem., 2022, 20, 2896
DOI: 10.1039/D2OB00101B

Rhodium-catalysed additive-free carbonylation of benzamides with diethyl dicarbonate as a carbonyl source
Hirotsugu Suzuki, Seigo Kiyobe and Takanori Matsuda
Org. Biomol. Chem., 2024, 22, 2744
DOI: 10.1039/D4OB00059E

Metal-catalysed non-directed C(sp2)–H bond activation
Shubham K. Agrawal, Sandip Porey, Yogesh Bairagi, Siddhartha Maiti, Alex C. Bissember and Debabrata Maiti
Chem. Soc. Rev., 2025, 54, 6122
DOI: 10.1039/D5CS00165J

Catalyst-free and additive-free reactions enabling C–C bond formation: a journey towards a sustainable future
Biswajita Baruah and Mohit L. Deb
Org. Biomol. Chem., 2021, 19, 1191
DOI: 10.1039/D0OB02149K

Rhodium(iii)-catalyzed regioselective C(sp2)–H activation of indoles at the C4-position with iodonium ylides
Fuhai Wu, Lin Xiao, Hui Xie, Shao-Yong Chen, Jia-Lin Song, Yi-Chuan Zheng, Yan-Zhi Liu and Shang-Shi Zhang
Org. Biomol. Chem., 2022, 20, 5055
DOI: 10.1039/D2OB00722C

Recent advances in transition metal-catalyzed olefinic C–H functionalization
Bingxian Liu, Lingyun Yang, Pengfei Li, Fen Wang and Xingwei Li
Org. Chem. Front., 2021, 8, 1085
DOI: 10.1039/D0QO01159B

Visible light-promoted photocatalyst-free activation of persulfates: a promising strategy for C–H functionalization reactions
Sudipta Saha and Avik Kumar Bagdi
Org. Biomol. Chem., 2022, 20, 3249
DOI: 10.1039/D2OB00109H

Pd-catalyzed bidentate auxiliary assisted remote C(sp3)–H functionalization
Kangkan Talukdar, Tariq A. Shah, Tanumay Sarkar, Subhasish Roy, Prabhat Kumar Maharana and Tharmalingam Punniyamurthy
Chem. Commun., 2021, 57, 13221
DOI: 10.1039/D1CC05291H

Rhodium-catalyzed regioselective C–H activation/Lossen rearrangement/annulation for the green synthesis of trisubstituted 2-pyridones
Yidi Li, Huiying Xu, Lin Huang, Zhi Zhou, Zhenhao Tang, Haifang Meng, Wei Zhang, Wei Yi and Xiaowei Wu
Org. Chem. Front., 2023, 10, 3000
DOI: 10.1039/D3QO00469D

Carbene functionalization of porphyrinoids through tosylhydrazones
Grigory L. Kozhemyakin, Vladimir S. Tyurin, Alena O. Shkirdova, Evgeny S. Belyaev, Ekaterina S. Kirinova, Gelii V. Ponomarev, Alexey A. Chistov, Andrey V. Aralov, Victor A. Tafeenko and Ilya A. Zamilatskov
Org. Biomol. Chem., 2021, 19, 9199
DOI: 10.1039/D1OB01626A

Nickel/Brønsted acid dual-catalyzed regioselective C–H bond allylation of phenols with 1,3-dienes
Jiao Long, Chao Ding and Guoyin Yin
Org. Chem. Front., 2022, 9, 3834
DOI: 10.1039/D2QO00637E

The C–H functionalization of N-alkoxycarbamoyl indoles by transition metal catalysis
Prasanjit Ghosh and Sajal Das
Org. Biomol. Chem., 2021, 19, 7949
DOI: 10.1039/D1OB01121A

Visible light promoted C–H functionalization of imidazoheterocycles
Avik Kumar Bagdi and Alakananda Hajra
Org. Biomol. Chem., 2020, 18, 2611
DOI: 10.1039/D0OB00246A

Magnetically recoverable nickel-palladium alloy nanocatalysts for direct C–H arylation reactions
Yunus Zozik, Melike Sevim, Ferruh Lafzi, Haydar Kilic and Önder Metin
Dalton Trans., 2021, 50, 17515
DOI: 10.1039/D1DT02985A

Origin of ligand-controlled regioselectivity in Co-catalyzed borylation of fluorinated arenes
Xiaofang Zhai, Han Gao, Feng Ye, Wujie Wang, Yuliang Li and Gang Lu
Org. Chem. Front., 2025
DOI: 10.1039/D5QO00897B

C–H bond functionalization by high-valent cobalt catalysis: current progress, challenges and future perspectives
Lukass Lukasevics, Aleksandrs Cizikovs and Liene Grigorjeva
Chem. Commun., 2021, 57, 10827
DOI: 10.1039/D1CC04382J

Metallaphotoredox catalysis for sp3C–H functionalizations through hydrogen atom transfer (HAT)
Jingchang Zhang and Magnus Rueping
Chem. Soc. Rev., 2023, 52, 4099
DOI: 10.1039/D3CS00023K

Recent advances in cobalt-catalysed C–H functionalizations
Alessio Baccalini, Stefania Vergura, Pravas Dolui, Giuseppe Zanoni and Debabrata Maiti
Org. Biomol. Chem., 2019, 17, 10119
DOI: 10.1039/C9OB01994D

Chiral amino acids: evolution in atroposelective C–H activation
Diksha Parmar, Rohit Kumar and Upendra Sharma
Org. Biomol. Chem., 2024, 22, 5032
DOI: 10.1039/D4OB00739E

Palladium(ii)-catalyzed asymmetric C–H carbonylation to diverse isoquinoline derivatives bearing all-carbon quaternary stereocenters
Yan Li, Xiu-Fen Cheng, Fan Fei, Tian-Rui Wu, Kang-Jie Bian, Xin Zhou and Xi-Sheng Wang
Chem. Commun., 2020, 56, 11605
DOI: 10.1039/D0CC05219A

Visible-light-promoted α-methoxymethylation and aminomethylation of ketones with methanol as the C1 source
Jingya Yang, Cai Liu, Hongyan Zhou, Rundong Fan, Ben Ma and Zheng Li
Org. Biomol. Chem., 2021, 19, 5572
DOI: 10.1039/D1OB00765C

Transition-metal-free radical relay cyclization of vinyl azides with 1,4-dihydropyridines involving a 1,5-hydrogen-atom transfer: access to α-tetralone scaffolds
Yangzhen Liao, Yu Ran, Guijun Liu, Peijun Liu and Xiaozu Liu
Org. Chem. Front., 2020, 7, 3638
DOI: 10.1039/D0QO01042A

The cross-coupling reaction of organoalane reagents with 2-methylthiobenzo[d]thiazolesviaC–S bond cleavage catalyzed by nickel
Xin Jiang, Hongliu Xiao, Xiaoying Jia, Jiaxia Pu, Lirong Han and Qinghan Li
New J. Chem., 2023, 47, 14078
DOI: 10.1039/D3NJ02026F

Diastereoselective C(sp3)–H acetoxylation of phosphoramidites
Anirban Mondal, Vanda Dašková, Xiaobing Chen, Niklas O. Thiel, Georgios Alachouzos and Ben L. Feringa
Chem. Commun., 2025, 61, 6510
DOI: 10.1039/D5CC00550G

Ru(ii)-Catalyzed regioselective carbene insertion into β-carbolines and isoquinolines
Stephy Elza John, Darshana Bora and Nagula Shankaraiah
Org. Biomol. Chem., 2022, 20, 5852
DOI: 10.1039/D2OB00946C

Recent advances in hydride transfer-involved C(sp3)–H activation reactions
Xiao-De An and Jian Xiao
Org. Chem. Front., 2021, 8, 1364
DOI: 10.1039/D0QO01502D

Divergent stereochemical outcomes in the insertion of donor/donor carbenes into the C–H bonds of stereogenic centers
Sarah N. Dishman, Croix J. Laconsay, James C. Fettinger, Dean J. Tantillo and Jared T. Shaw
Chem. Sci., 2022, 13, 1030
DOI: 10.1039/D1SC04622E

Precise control of the site selectivity in ruthenium-catalyzed C–H bond amidations using cyclic amides as powerful directing groups
Yu-Chao Yuan, Qiu-Li Lu, Xiao-Tong Zhu, Sergio Posada-Pérez, Miquel Solà, Albert Poater, Thierry Roisnel and Rafael Gramage-Doria
Org. Chem. Front., 2023, 10, 42
DOI: 10.1039/D2QO01434C

Rh(i)-catalysed imine-directed C–H functionalization via the oxidative [3 + 2] cycloaddition of benzylamine derivatives with maleimides
Amrita Das and Naoto Chatani
Chem. Commun., 2022, 58, 1123
DOI: 10.1039/D1CC06622F

Copper-catalyzed synthesis of pyrido-fused quinazolinones from 2-aminoarylmethanols and isoquinolines or tetrahydroisoquinolines
Thao T. Nguyen, Khang X. Nguyen, Phuc H. Pham, Duc Ly, Duyen K. Nguyen, Khoa D. Nguyen, Tung T. Nguyen and Nam T. S. Phan
Org. Biomol. Chem., 2021, 19, 4726
DOI: 10.1039/D1OB00229E

Synthetic applications of hydride abstraction reactions by organic oxidants
Jenna L. Miller, Jean-Marc I. A. Lawrence, Freddy O. Rodriguez del Rey and Paul E. Floreancig
Chem. Soc. Rev., 2022, 51, 5660
DOI: 10.1039/D1CS01169C

Chemoselective formal β-functionalization of substituted aliphatic amides enabled by a facile stereoselective oxidation event
Adriano Bauer and Nuno Maulide
Chem. Sci., 2019, 10, 9836
DOI: 10.1039/C9SC03715B

Chiral Cyclopentadienyl Cobalt(III) Complexes Enable Highly Enantioselective 3d-Metal-Catalyzed C–H Functionalizations
Kristers Ozols, Yun-Suk Jang and Nicolai Cramer
J. Am. Chem. Soc., 2019, 141, 5675
DOI: 10.1021/jacs.9b02569

Transition-Metal-Catalyzed C–H Activation Reactions for the Creation and Modification of Organic Fluorophores
Tapasi Chand and Manmohan Kapur
Synthesis, 2024, 56, 1505
DOI: 10.1055/a-2262-9575

N−H and C−H Functionalization of Sulfoximine: Recent Advancement and Prospects
Prasanjit Ghosh, Bhaskar Ganguly and Sajal Das
Asian J Org Chem, 2020, 9, 2035
DOI: 10.1002/ajoc.202000320

Synthetic Studies toward the Aphidicolin Family of Diterpenoid Natural Products
Jack Hayward Cooke, Safaa Jamshed and Richmond Sarpong
J. Org. Chem., 2025, 90, 9999
DOI: 10.1021/acs.joc.5c01047

Site-Selective Ruthenium-Catalyzed C–H Bond Arylations with Boronic Acids: Exploiting Isoindolinones as a Weak Directing Group
Yu-Chao Yuan, Christian Bruneau, Thierry Roisnel and Rafael Gramage-Doria
J. Org. Chem., 2019, 84, 12893
DOI: 10.1021/acs.joc.9b01563

Meta-Selective C–H Functionalization of Arylsilanes Using a Silicon Tethered Directing Group
Jaehan Bang, Seyun Gi, Yoonjung Lee, Kian L. Tan and Sunggi Lee
Org. Lett., 2022, 24, 5181
DOI: 10.1021/acs.orglett.2c02015

Sterically Controlled C−H Olefination of Heteroarenes
Hao Chen, Mirxan Farizyan, Francesca Ghiringhelli and Manuel van Gemmeren
Angew Chem Int Ed, 2020, 59, 12213
DOI: 10.1002/anie.202004521

Iron‐Catalysed C(sp2)‐H Borylation with Expanded Functional Group Tolerance†
Luke Britton, Jamie H. Docherty, Gary S. Nichol, Andrew P. Dominey and Stephen P. Thomas
Chin. J. Chem., 2022, 40, 2875
DOI: 10.1002/cjoc.202200465

Enzymatic Kinetic Resolution by Addition of Oxygen
Lucy A. Harwood, Luet L. Wong and Jeremy Robertson
Angewandte Chemie, 2021, 133, 4482
DOI: 10.1002/ange.202011468

Total Synthesis of (−)-Clavicipitic Acid via γ,γ-Dimethylallyltryptophan (DMAT) and Chemoselective C–H Hydroxylation
Francesca Bartoccini, Silvia Venturi, Michele Retini, Michele Mari and Giovanni Piersanti
J. Org. Chem., 2019, 84, 8027
DOI: 10.1021/acs.joc.9b00879

Rhodium(II)‐Catalyzed Site‐Selective Intramolecular Insertion of Aryldiazoacetates into Unactivated Primary C−H Bond: A Direct Route to 2‐Unsubstituted Indanes
Hisanori Nambu, Ryoya Amano, Takafumi Tamura and Takayuki Yakura
Adv Synth Catal, 2022, 364, 2422
DOI: 10.1002/adsc.202200115

Ir(III)‐Catalyzed C−H Alkylation of Aryl Ketone and Chromanone under Mild Conditions; Two‐Step Synthesis of Cytosporones B and N
Pitambar Patel, Arup Roy and Gongutri Borah
ChemistrySelect, 2023, 8
DOI: 10.1002/slct.202301423

Intermolekulare radikalische C(sp3)‐H‐Aminierung unter Iod‐Katalyse
Alexandra E. Bosnidou and Kilian Muñiz
Angewandte Chemie, 2019, 131, 7564
DOI: 10.1002/ange.201901673

Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation
Yumei Huo, Beibei Chen, Xiaoyu Ren, Chao Wang, Rupeng Qi and Zhaoqing Xu
Green Synthesis and Catalysis, 2025, 6, 114
DOI: 10.1016/j.gresc.2023.11.004

Catalytic Synthesis of Atropoisomers via Non‐Canonical Friedel‐Crafts Reactions
Xutong Ye, Xixiang Yu, Rui Deng, Fangrui Zhong and Guojiao Wu
Adv Synth Catal, 2024, 366, 1670
DOI: 10.1002/adsc.202400084

Cobalt‐Catalyzed Enantioselective C−H Carbonylation towards Chiral Isoindolinones
Ming‐Ya Teng, Yong‐Jie Wu, Jia‐Hao Chen, Fan‐Rui Huang, De‐Yang Liu, Qi‐Jun Yao and Bing‐Feng Shi
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202318803

Copper-catalyzed remote trifluoromethylthiolation-peroxidation of unactivated alkenes via 1,5-hydrogen atom transfer
Leilei Wang, Shiming Shu, Leiyang Lv and Zhiping Li
Tetrahedron Letters, 2022, 104, 154029
DOI: 10.1016/j.tetlet.2022.154029

Free Amine-Directed Redox Neutral Ruthenium(II) Catalysis toward Regioselective Synthesis of Heterobiaryls
Suman Ghosh, Mainak Koner, Anusree A. Kunhiraman and Mahiuddin Baidya
Org. Lett., 2024, 26, 2987
DOI: 10.1021/acs.orglett.4c00568

Enzymatic and Bio-Inspired Enantioselective Oxidation of Non-Activated C(sp 3)–H Bonds
Andrea Palone, Massimo Bietti and Miquel Costas
Synthesis, 2025, 57, 1280
DOI: 10.1055/a-2403-0760

Synthesis of Dibenzosuberones Bearing an Isoxazole Group via Palladium-Catalyzed Intramolecular C–H/C–Br Bond Cross-Coupling of Ortho-Aroylated 3,5-Diarylisoxazoles
Tung Chao, Zhe-Hong Su, Ko-Wang Yen, Ming-Jung Wu and Jean-Ho Chu
J. Org. Chem., 2020, 85, 5559
DOI: 10.1021/acs.joc.0c00346

Two-Phase Total Synthesis of Taxanes: Tactics and Strategies
Yuzuru Kanda, Yoshihiro Ishihara, Nathan C. Wilde and Phil S. Baran
J. Org. Chem., 2020, 85, 10293
DOI: 10.1021/acs.joc.0c01287

Site Selective Chlorination of C(sp3)−H Bonds Suitable for Late‐Stage Functionalization
Alexander Fawcett, M. Josephine Keller, Zachary Herrera and John F. Hartwig
Angew Chem Int Ed, 2021, 60, 8276
DOI: 10.1002/anie.202016548

Photoredox‐Mediated Hydrogen Isotope Exchange Reactions of Amino‐Acids, Peptides, and Peptide‐Derived Drugs
Fabien Legros, Patricia Fernandez‐Rodriguez, Anurag Mishra, Remo Weck, Armin Bauer, Martin Sandvoss, Sven Ruf, María Méndez, Helena Mora‐Radó, Nils Rackelmann, Christoph Pöverlein and Volker Derdau
Chemistry A European J, 2020, 26, 12738
DOI: 10.1002/chem.202003464

Site‐Selective C(sp3)−H and C(sp2)−H Functionalization of Amines Using a Directing‐Group‐Guided Strategy
Mohit Kapoor, Adhish Singh, Kirti Sharma and Ming Hua Hsu
Adv Synth Catal, 2020, 362, 4513
DOI: 10.1002/adsc.202000689

11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C–H Functionalizations
Baiyang Jiang and Mingji Dai
J. Am. Chem. Soc., 2021, 143, 20084
DOI: 10.1021/jacs.1c11060

The Recent Advances in Iron‐Catalyzed C(sp3)−H Functionalization
Desai Bhavyesh, Sudha Soliya, Ramaiah Konakanchi, Eeshwaraiah Begari, Kashamalla Chinna Ashalu and Togati Naveen
Chemistry — An Asian Journal, 2024, 19
DOI: 10.1002/asia.202301056

Nucleophilic C–H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer
Thomas R. Puleo, Danielle R. Klaus and Jeffrey S. Bandar
J. Am. Chem. Soc., 2021, 143, 12480
DOI: 10.1021/jacs.1c06481

Copper-catalyzed sp3-carbon radical/carbamoyl radical cross coupling: A direct strategy for carbamoylation of 1,3-dicarbonyl compounds
Xu-Ping Yan, Cheng-Kun Li, Shao-Fang Zhou, Adedamola Shoberu and Jian-Ping Zou
Tetrahedron, 2020, 76, 131342
DOI: 10.1016/j.tet.2020.131342

Palladium-Mediated Remote Functionalization in γ- and ε-Arylations and Alkenylations of Unblocked Cyclic Enones
Gaurav Saini, Arpan Mondal and Manmohan Kapur
Org. Lett., 2019, 21, 9071
DOI: 10.1021/acs.orglett.9b03462

Electrochemical Benzylic C─H Sulfation beyond the O‐Sulfonation Limitation
Wei Sheng, Huanhuan Peng, Ben Gao, Chunlan Song and Jiakun Li
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202507048

Catalytic Behavior of Mono‐N‐Protected Amino‐Acid Ligands in Ligand‐Accelerated C−H Activation by Palladium(II)
Chase A. Salazar, Joseph J. Gair, Kaylin N. Flesch, Ilia A. Guzei, Jared C. Lewis and Shannon S. Stahl
Angew Chem Int Ed, 2020, 59, 10873
DOI: 10.1002/anie.202002484

Scope and Mechanism of the Ruthenium-Catalyzed sp3 C–H Coupling Reaction of 2-Alkylindoles with Enones for the Synthesis of Carbazole Derivatives
Krishna Prasad Gnyawali, Mina Son, Donghun Hwang, Nuwan Pannilawithana, Mu-Hyun Baik and Chae S. Yi
Organometallics, 2025, 44, 325
DOI: 10.1021/acs.organomet.4c00470

Strategies Toward the Catalyst-Free α-C–H Functionalizations of Tertiary Amines
Mohit L. Deb and Pranjal K. Baruah
Top Curr Chem (Z), 2023, 381
DOI: 10.1007/s41061-023-00424-x

Ruthenium-Catalyzed Enantioselective C–H Functionalization: A Practical Access to Optically Active Indoline Derivatives
Zhong-Yuan Li, Hetti Handi Chaminda Lakmal, Xiaolin Qian, Zhenyu Zhu, Bruno Donnadieu, Sarah J. McClain, Xue Xu and Xin Cui
J. Am. Chem. Soc., 2019, 141, 15730
DOI: 10.1021/jacs.9b07251

Rh(III)-Catalyzed Redox-Neutral C–H Activation/[3 + 2] Annulation of N-Phenoxy Amides with Propargylic Monofluoroalkynes
Xiuhua Zhong, Shuang Lin, Hui Gao, Fu-Xiaomin Liu, Zhi Zhou and Wei Yi
Org. Lett., 2021, 23, 2285
DOI: 10.1021/acs.orglett.1c00418

Transition Metal‐Catalysed Direct C−H Bond Functionalizations of 2‐Pyridone Beyond C3‐Selectivity
Aniruddha Biswas, Saurabh Maity, Subarna Pan and Rajarshi Samanta
Chemistry — An Asian Journal, 2020, 15, 2092
DOI: 10.1002/asia.202000506

Multiple Catalytic C−H Bond Functionalization for Natural Product Synthesis
Olivier Baudoin
Angew Chem Int Ed, 2020, 59, 17798
DOI: 10.1002/anie.202001224

Diversification of (E,E)-1,6-Dioxo-2,4-Dienes for the Synthesis of (+)-Aspicillin, Isolaurepan, and β-Parinaric Acid
Dattatraya H. Dethe, Aparna Srivastava, Appasaheb K. Nirpal, Nagabhushana C. Beeralingappa, Vimlesh Kumar and Arsheed A. Bhat
J. Org. Chem., 2022, 87, 11021
DOI: 10.1021/acs.joc.2c01280

Recent Development of Photoinduced Iron-Catalysis in Organic Synthesis
Qian Dou, Taimin Wang, Lijing Fang, Hongbin Zhai and Bin Cheng
Chinese Journal of Organic Chemistry, 2023, 43, 1386
DOI: 10.6023/cjoc202209001

Conformational Design Principles in Total Synthesis
Renzhi Chen, Yang Shen, Sihan Yang and Yandong Zhang
Angewandte Chemie, 2020, 132, 14302
DOI: 10.1002/ange.202003735

Methylene C(sp3)−H Arylation Enables the Stereoselective Synthesis and Structure Revision of Indidene Natural Products
Anton Kudashev, Stefania Vergura, Marco Zuccarello, Thomas Bürgi and Olivier Baudoin
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202316103

Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C–H Functionalizations
Yuan Jin, Sovanneary Hok, John Bacsa and Mingji Dai
J. Am. Chem. Soc., 2024, 146, 1825
DOI: 10.1021/jacs.3c13492

Enzymatic Kinetic Resolution by Addition of Oxygen
Lucy A. Harwood, Luet L. Wong and Jeremy Robertson
Angew Chem Int Ed, 2021, 60, 4434
DOI: 10.1002/anie.202011468

Synthesis of Unnatural α-Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)–H Bonds
Florence Babawale, Kathiravan Murugesan, Rok Narobe and Burkhard König
Org. Lett., 2022, 24, 4793
DOI: 10.1021/acs.orglett.2c01822

Benzimidazole-based Nheterocyclic carbene ruthenium(II) complexes: Synthesis and C H bond activation properties
Mitat Akkoç
Journal of Molecular Structure, 2022, 1270, 133999
DOI: 10.1016/j.molstruc.2022.133999

Progress of Metal‐Free Visible‐Light‐Driven α‐C−H Functionalization of Tertiary Amines: A Decade Journey
Mohit L. Deb, B. Shriya Saikia, Paran J. Borpatra and Pranjal K. Baruah
Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202100706

Bioinspired Palladium‐Catalyzed Intramolecular C(sp3)−H Activation for the Collective Synthesis of Proline Natural Products
Quan‐Zhe Li, Si‐Hua Hou, Jun‐Chen Kang, Peng‐Fei Lian, Yu Hao, Chao Chen, Jia Zhou, Tong‐Mei Ding and Shu‐Yu Zhang
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202207088

Rh(III)-Catalyzed Reaction of α-Carbonyl Sulfoxonium Ylides and Alkenes: Synthesis of Indanones via [4 + 1] Cycloaddition
Yadagiri Kommagalla, Shunsuke Ando and Naoto Chatani
Org. Lett., 2020, 22, 1375
DOI: 10.1021/acs.orglett.9b04664

Programmable late-stage C−H bond functionalization enabled by integration of enzymes with chemocatalysis
Elliott J. Craven, Jonathan Latham, Sarah A. Shepherd, Imtiaz Khan, Alba Diaz-Rodriguez, Michael F. Greaney and Jason Micklefield
Nat Catal, 2021, 4, 385
DOI: 10.1038/s41929-021-00603-3

Activation of Heteroaromatic C–H Bonds in Furan and 2,5-Dimethylfuran
Richard D. Adams, Poonam Dhull, Meenal Kaushal and Mark D. Smith
Inorg. Chem., 2019, 58, 6008
DOI: 10.1021/acs.inorgchem.9b00328

Metal‐Free One‐Pot Three‐Component Synthesis of Quinazoline Derivatives via Peroxide‐Mediated Direct Oxidative Amination of C(sp3)–H Bonds
Tien V. Huynh, Son H. Doan, Khang H. Trinh, Trang H. Ly, Anh L. T. Phan, Tung T. Nguyen, Anh N. Q. Phan and Nam T. S. Phan
ChemistrySelect, 2019, 4, 11808
DOI: 10.1002/slct.201903154

[2.2]Benzoindenophane‐Based Chiral Indenyl Ligands: Design, Synthesis, and Applications in Asymmetric C−H Activation
Weicong Guo, Jijun Jiang and Jun Wang
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202400279

Mehrfache katalytische C‐H‐Bindungsfunktionalisierungen in der Naturstoffsynthese
Olivier Baudoin
Angewandte Chemie, 2020, 132, 17950
DOI: 10.1002/ange.202001224

Recent Advances in Functionalization of Aromatic C(sp2)—H Bonds Based on N-Nitroso Direction
Fang Wang and Lei Wang
Chinese Journal of Organic Chemistry, 2023, 43, 4157
DOI: 10.6023/cjoc202305029

Unlocking the Nucleophilicity of Strong Alkyl C–H Bonds via Cu/Cr Catalysis
Pan Peng, Yifan Zhong, Cong Zhou, Yongsheng Tao, Dandan Li and Qingquan Lu
ACS Cent. Sci., 2023, 9, 756
DOI: 10.1021/acscentsci.2c01389

Regioselective Olefination of 3‐Substituted Five‐Membered Heteroarenes
Hao Chen, Mirxan Farizyan and Manuel van Gemmeren
Eur J Org Chem, 2020, 2020, 6318
DOI: 10.1002/ejoc.202000659

Tandem C–C/C–N Bond Formation via Rh(III)-Catalyzed α-Fluoroalkenylation and Sequential Annulation of 2-Arylquinazolinones and gem-Difluorostyrenes
Binghan Pang, Yangyang Wang, Liqiang Hao, Gaorong Wu, Zhihong Ma and Yafei Ji
J. Org. Chem., 2023, 88, 143
DOI: 10.1021/acs.joc.2c02006

Aspartyl β-Turn-Based Dirhodium(II) Metallopeptides for Benzylic C(sp3)–H Amination: Enantioselectivity and X-ray Structural Analysis
Naudin van den Heuvel, Savannah M. Mason, Brandon Q. Mercado and Scott J. Miller
J. Am. Chem. Soc., 2023, 145, 12377
DOI: 10.1021/jacs.3c03587

Site Selective Chlorination of C(sp3)−H Bonds Suitable for Late‐Stage Functionalization
Alexander Fawcett, M. Josephine Keller, Zachary Herrera and John F. Hartwig
Angewandte Chemie, 2021, 133, 8357
DOI: 10.1002/ange.202016548

Highlights of aliphatic C(sp3)‐H hydrogen isotope exchange reactions
Mégane Valero and Volker Derdau
Labelled Comp Radiopharmac, 2020, 63, 266
DOI: 10.1002/jlcr.3783

Mechanistic insights for Aryl dilithium base enables the acylation of unactivated Csp3H
Changming Li, Hongdan Zhu, Can-Can Bao, Yongjia Lin, Bing-Tao Guan and Qian Peng
Chinese Chemical Letters, 2025, 36, 110809
DOI: 10.1016/j.cclet.2024.110809

Gold(III) Auracycles Featuring C(sp3)‐Au‐C(sp2) Bonds: Synthesis and Mechanistic Insights into the Cycloauration Step
Jorge A. González, Andrés Arribas, Puyang Tian, Sergio Díaz‐Alonso, José Luis Mascareñas, Fernando López and Cristina Nevado
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202402798

Light‐driven catalysis with engineered enzymes and biomimetic systems
Emily H. Edwards and Kara L. Bren
Biotech and App Biochem, 2020, 67, 463
DOI: 10.1002/bab.1976

Regioselective Hydroxylation of Flavonoids by Transition-Metal-Catalyzed C–H Bond Oxidation
Shu-Min Lu, Chao Chen, Chang Liu, Rudong Liu, Jia-Hua Chen, Zhongchao Zhang and Zhen Yang
Org. Lett., 2023, 25, 2264
DOI: 10.1021/acs.orglett.3c00517

Silver Ions Promoted Palladium-Catalyzed Inactive β-C(sp3)–H Bond Arylation in Batch and Continuous-Flow Conditions
Maram Gangadhar, Vankudoth Ramesh, Vadla Shiva Prasad and Praveen Reddy Adiyala
J. Org. Chem., 2022, 87, 9607
DOI: 10.1021/acs.joc.2c00606

Transition Metals Catalyzed Direct C-H Chalcogenation of Arenes and Heteroarenes
Atanu Mahata, Madhusudan Garain, Totan Roy, Dilip Gorai and Debasish Kundu
COS, 2024, 21, 764
DOI: 10.2174/1570179420666230428122124

Pd(II)‐Catalyzed Tandem Enantioselective Methylene C(sp3)−H Alkenylation–Aza‐Wacker Cyclization to Access β‐Stereogenic γ‐Lactams
Yi Ding, Ye‐Qiang Han, Le‐Song Wu, Tao Zhou, Qi‐Jun Yao, Ya‐Lan Feng, Ya Li, Ke‐Xin Kong and Bing‐Feng Shi
Angew Chem Int Ed, 2020, 59, 14060
DOI: 10.1002/anie.202004504

“Iron catalyzed alkynylation of thiohydantoins with terminal alkyne via cross-dehydrogenative coupling (CDC)”
Mayur I. Morja, Prakashsingh M. Chauhan and Kishor H. Chikhalia
Tetrahedron Letters, 2021, 77, 153148
DOI: 10.1016/j.tetlet.2021.153148

Enantioselective Synthesis of Triarylmethanes via Intermolecular C–H Functionalization of Cyclohexadienes with Diaryldiazomethanes
Maizie Lee and Huw M. L. Davies
Org. Lett., 2023, 25, 4000
DOI: 10.1021/acs.orglett.3c00845

Carbon–nitrogen transmutation in polycyclic arenol skeletons to access N-heteroarenes
Hong Lu, Yu Zhang, Xiu-Hong Wang, Ran Zhang, Peng-Fei Xu and Hao Wei
Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-48265-6

Ultralarge-Scale Synthesis of Uniformly Dispersive Ultrafine Copper Nanoparticles/Copper(II)-Benzene-1,3,5-tricarboxylate for Selective C2-Acylation of Indole with α-Oxocarboxylic Acids
Fangshu Han, Lin Zhang, Junhao Shao, Yanqiu Ma, Shuai Yang, Changyan Guo, Jide Wang, Chenjiang Liu and Yonghong Zhang
Langmuir, 2025, 41, 19282
DOI: 10.1021/acs.langmuir.5c01700

Asymmetric Total Synthesis of Sarpagine and Koumine Alkaloids
Zhao Yang, Qiuyuan Tan, Yan Jiang, Jiaojiao Yang, Xiaojiao Su, Zhen Qiao, Wenqiang Zhou, Ling He, Hanyue Qiu and Min Zhang
Angewandte Chemie, 2021, 133, 13215
DOI: 10.1002/ange.202102416

Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity
Susanna Kunz, Fredrik Barnå, Mauricio Posada Urrutia, Fredric J. L. Ingner, Andrea Martínez-Topete, Andreas Orthaber, Paul J. Gates, Lukasz T. Pilarski and Christine Dyrager
J. Org. Chem., 2024, 89, 6138
DOI: 10.1021/acs.joc.4c00122

Recent Advances in Construction of Polycyclic Natural Product Scaffolds via One-Pot Reactions Involving Alkyne Annulation
Liyao Zheng and Ruimao Hua
Front. Chem., 2020, 8
DOI: 10.3389/fchem.2020.580355

Amine‐Free, Directing‐Group‐Free and Redox‐Neutral α‐Alkylation of Saturated Cyclic Ketones
Jia Qiao, Rui‐Nan Ci, Qi‐Chao Gan, Cheng Huang, Zan Liu, Hui‐Lan Hu, Chen Ye, Bin Chen, Chen‐Ho Tung and Li‐Zhu Wu
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202305679

Recent advances in the diversification of chromones and flavones by direct C H bond activation or functionalization
Shanghui Tian, Tian Luo, Yanping Zhu and Jie-Ping Wan
Chinese Chemical Letters, 2020, 31, 3073
DOI: 10.1016/j.cclet.2020.07.042

Introduction to Spatial Anion Control for Direct C–H Arylation
Jyoti Dhankhar and Ilija Čorić
Synlett, 2022, 33, 503
DOI: 10.1055/s-0040-1719860

Selective Ruthenium‐Catalyzed Photoredox α‐C(sp3)–H Alkynylation of Cyclic Amines under Visible Light
Caren D. G. Silva, Douglas B. Paixão, Eduardo G. O. Soares and Paulo H. Schneider
Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202500254

Advances in amide and thioamide assisted C(sp3) H functionalization
Peng Wen Tan and Jayasree Seayad
Tetrahedron Letters, 2019, 60, 151338
DOI: 10.1016/j.tetlet.2019.151338

Organocatalyst-controlled site-selective arene C–H functionalization
Jian-Hui Mao, Yong-Bin Wang, Limin Yang, Shao-Hua Xiang, Quan-Hao Wu, Yuan Cui, Qian Lu, Jie Lv, Shaoyu Li and Bin Tan
Nat. Chem., 2021, 13, 982
DOI: 10.1038/s41557-021-00750-x

Biocatalytic, Intermolecular C−H Bond Functionalization for the Synthesis of Enantioenriched Amides
Soumitra V. Athavale, Shilong Gao, Zhen Liu, Sharath Chandra Mallojjala, Jennifer S. Hirschi and Frances H. Arnold
Angew Chem Int Ed, 2021, 60, 24864
DOI: 10.1002/anie.202110873

A photoredox-catalyzed approach for formal hydride abstraction to enable C –H functionalization with nucleophilic partners (F, C, O, N, and Br/Cl)
Yufei Zhang, Nicholas A. Fitzpatrick, Mrinmoy Das, Ishani P. Bedre, Hatice G. Yayla, Manjinder S. Lall and Patricia Z. Musacchio
Chem Catalysis, 2022, 2, 292
DOI: 10.1016/j.checat.2021.12.010

Tertiary Arsine Ligands for Pd-Catalyzed Direct Arylation
Kenta Ogawa, Akifumi Sumida, Takashi Yumura, Hiroaki Imoto and Kensuke Naka
Organometallics, 2024, 43, 322
DOI: 10.1021/acs.organomet.3c00464

Cobalt-Catalyzed 2-(1-Methylhydrazinyl)pyridine-Assisted C–H Alkylation/Annulation: Mechanistic Insights and Rapid Access to Cyclopenta[c]isoquinolinone Derivatives
Hongbin Zhai, Miao Liu, Chao Wang, Shuxian Qiu, Jian Wei, Hongjian Yang and Yundong Wu
J. Org. Chem., 2021, 86, 14915
DOI: 10.1021/acs.joc.1c01658

Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily
Chi (Chip) Le, Minwoo Bae, Sina Kiamehr and Emily P. Balskus
Annu. Rev. Biochem., 2022, 91, 475
DOI: 10.1146/annurev-biochem-032620-110804

Exploiting photoredox catalysis for carbohydrate modification through C–H and C–C bond activation
Andrey Shatskiy, Elena V. Stepanova and Markus D. Kärkäs
Nat Rev Chem, 2022, 6, 782
DOI: 10.1038/s41570-022-00422-5

Palladium-Catalyzed Regiospecific peri- and ortho-C–H Oxygenations of Polyaromatic Rings Mediated by Tunable Directing Groups
Jing Jiang, Dandan Yuan, Congzhe Ma, Wanbin Song, Yaoyu Lin, Lihong Hu and Yinan Zhang
Org. Lett., 2021, 23, 279
DOI: 10.1021/acs.orglett.0c03701

Total synthesis of (−)-cylindrocyclophane A facilitated by C−H functionalization
Aaron T. Bosse, Liam R. Hunt, Camila A. Suarez, Tyler D. Casselman, Elizabeth L. Goldstein, Austin C. Wright, Hojoon Park, Scott C. Virgil, Jin-Quan Yu, Brian M. Stoltz and Huw M. L. Davies
Science, 2024, 386, 641
DOI: 10.1126/science.adp2425

Palladium-catalyzed benzylic C(sp3)–H arylation of o-alkylbenzaldehydes
Lan Lei, Ping Wu, Zhuqing Liu and Jiang Lou
Tetrahedron Letters, 2021, 67, 152865
DOI: 10.1016/j.tetlet.2021.152865

Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds
Zhi-Yun Liu and Silas P. Cook
Org. Lett., 2022, 24, 3313
DOI: 10.1021/acs.orglett.2c00447

Mechanochemical Solvent‐Free Catalytic C−H Methylation
Shengjun Ni, Matic Hribersek, Swarna K. Baddigam, Fredric J. L. Ingner, Andreas Orthaber, Paul J. Gates and Lukasz T. Pilarski
Angew Chem Int Ed, 2021, 60, 6660
DOI: 10.1002/anie.202010202

Development of Chiral Ligands for the Transition‐Metal‐Catalyzed Enantioselective Silylation and Borylation of C−H Bonds
Bo Su and John F. Hartwig
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202113343

Mechanistic Investigations of Cobalt-Catalyzed, Aminoquinoline-Directed C(sp2)–H Bond Functionalization
Lukass Lukasevics, George N. Oh, Xiqu Wang, Liene Grigorjeva and Olafs Daugulis
J. Am. Chem. Soc., 2025, 147, 2476
DOI: 10.1021/jacs.4c13086

Asymmetric Synthesis of Enantiopure Pyrrolidines by C(sp3)−H Amination of Hydrocarbons
Yanis Lazib, Pascal Retailleau, Tanguy Saget, Benjamin Darses and Philippe Dauban
Angew Chem Int Ed, 2021, 60, 21708
DOI: 10.1002/anie.202107898

Differentiation and functionalization of remote C–H bonds in adjacent positions
Hang Shi, Yi Lu, Jiang Weng, Katherine L. Bay, Xiangyang Chen, Keita Tanaka, Pritha Verma, Kendall N. Houk and Jin-Quan Yu
Nat. Chem., 2020, 12, 399
DOI: 10.1038/s41557-020-0424-5

Construction of Polyheterocyclic Skeletons through C−H Bond Activation‐Initiated Cascade Reactions by Using Cyclopropanol as Alkylating Agent as well as Masked Nucleophile and Electrophile
Xueying Yang, Xinyuan Cai, Xinying Zhang and Xuesen Fan
Adv Synth Catal, 2024, 366, 141
DOI: 10.1002/adsc.202301172

Rh(III)-Catalyzed C(sp3)–H Thiolation of 8-Methylquinolines Promoted by Benzoic Anhydride
Cheng-Kai Yuan, Yan-Nian Pan, Yi-Fei Wu, Wei-Yin Sun, Zhen Meng and Yi Lu
J. Org. Chem., 2024, 89, 11975
DOI: 10.1021/acs.joc.4c00559

Divergent Synthesis of Bioactive Dithiodiketopiperazine Natural Products Based on a Double C(sp3)−H Activation Strategy
Pierre Thesmar, Seemon Coomar, Alessandro Prescimone, Daniel Häussinger, Dennis Gillingham and Olivier Baudoin
Chemistry A European J, 2020, 26, 15298
DOI: 10.1002/chem.202003683

Catalytic, Enantioselective C2-Functionalization of 3-Aminobenzofurans Using N-Heterocyclic Carbenes
Shilpa Barik, Sayan Shee, Arghya Ghosh and Akkattu T. Biju
Org. Lett., 2020, 22, 3865
DOI: 10.1021/acs.orglett.0c01112

para‐Selective Arylation of Arenes: A Direct Route to Biaryls by Norbornene Relay Palladation
Uttam Dutta, Sandip Porey, Sandeep Pimparkar, Astam Mandal, Jagrit Grover, Adithyaraj Koodan and Debabrata Maiti
Angew Chem Int Ed, 2020, 59, 20831
DOI: 10.1002/anie.202005664

Dual Metallaphotoredox‐Catalyzed Directed C(sp2)−H Functionalization: Access to C−C/C‐Heteroatom Bonds
Tanumay Sarkar, Tariq A. Shah, Prabhat Kumar Maharana, Bijoy Debnath and Tharmalingam Punniyamurthy
Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202200541

Photochemically Mediated Ring Expansion of Indoles and Pyrroles with Chlorodiazirines: Synthetic Methodology and Thermal Hazard Assessment
Ben W. Joynson, Graham R. Cumming and Liam T. Ball
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202305081

Enantioselective Pd0‐Catalyzed C(sp2)–H Arylation for the Synthesis of Chiral Warped Molecules
David Savary and Olivier Baudoin
Angew Chem Int Ed, 2021, 60, 5136
DOI: 10.1002/anie.202013303

Visible‐Light Mediated C‐3 Amination of Quinoxalin‐ 2(1H)‐ones via Electron Donor‐Acceptor Complexation
Devidas A. More, P. R. Gayathri, Kishor R. Thete and M. Muthukrishnan
Asian J Org Chem, 2024, 13
DOI: 10.1002/ajoc.202400150

Ru3(CO)12‐Catalyzed Modular Assembly of Hemilabile Ligands by C−H Activation of Phosphines with Isocyanates
Lin Lin, Xue‐jun Zhang, Xinyu Xu, Yue Zhao and Zhuangzhi Shi
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202214584

Kinetic Resolution of Allyltriflamides through a Pd-Catalyzed C–H Functionalization with Allenes: Asymmetric Assembly of Tetrahydropyridines
José Manuel González, Borja Cendón, José Luis Mascareñas and Moisés Gulías
J. Am. Chem. Soc., 2021, 143, 3747
DOI: 10.1021/jacs.1c01929

Transition‐Metal‐Catalyzed Directing Group Assisted (Hetero)aryl C−H Functionalization: Construction of C−C/C‐Heteroatom Bonds
Tanumay Sarkar, Tariq A. Shah, Prabhat Kumar Maharana, Kangkan Talukdar, Bijay Ketan Das and Tharmalingam Punniyamurthy
The Chemical Record, 2021, 21, 3758
DOI: 10.1002/tcr.202100143

Skeletal Editing: Interconversion of Arenes and Heteroarenes
Ben W. Joynson and Liam T. Ball
Helvetica Chimica Acta, 2023, 106
DOI: 10.1002/hlca.202200182

Iridium nitrenoid-enabled arene C−H functionalization
Liang-Wen Qi, Torben Rogge, K. N. Houk and Yixin Lu
Nat Catal, 2024, 7, 934
DOI: 10.1038/s41929-024-01207-3

Recent advances in remote C(sp3)–H functionalization via chelating group-assisted metal-catalyzed chain-walking reaction
Jian Han, Li-Li Zeng, Qin-Yu Fei, Yan-Xiang Ge, Rong-Hui Huang and Fen-Er Chen
Chinese Chemical Letters, 2024, 35, 109647
DOI: 10.1016/j.cclet.2024.109647

Total Synthesis of Dalesconol A by Pd(0)/Norbornene-Catalyzed Three-Fold Domino Reaction and Pd(II)-Catalyzed Trihydroxylation
Ping Zhao, Yun Guo and Xinjun Luan
J. Am. Chem. Soc., 2021, 143, 21270
DOI: 10.1021/jacs.1c12118

Propargyl Alcohols as Bifunctional Reagents for Divergent Annulations of Biphenylamines via Dual C−H Functionalization/Dual Oxidative Cyclization
Dattatri, Maneesh Kumar Reddy Singam, Suresh Vavilapalli, Jagadeesh Babu Nanubolu and Maddi Sridhar Reddy
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202215825

Asymmetric Total Syntheses of (−)-Fennebricin A, (−)-Renieramycin J, (−)-Renieramycin G, (−)-Renieramycin M, and (−)- Jorunnamycin A via C–H Activation
Yu Zheng, Xue-Dan Li, Peng-Zhen Sheng, Hong-Dou Yang, Kun Wei and Yu-Rong Yang
Org. Lett., 2020, 22, 4489
DOI: 10.1021/acs.orglett.0c01493

Advancing the Logic of Chemical Synthesis: C−H Activation as Strategic and Tactical Disconnections for C−C Bond Construction
Nelson Y. S. Lam, Kevin Wu and Jin‐Quan Yu
Angewandte Chemie, 2021, 133, 15901
DOI: 10.1002/ange.202011901

Palladium‐Catalyzed Regioselectivity C─H Oxidation of Aromatics Utilizing Removable Directing Group Strategy
Shuwei Zhu, Yong Wang, Fumeng Yin, Yuqing Gu and Hongjun Zhu
ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202405019

Diastereoselective Synthesis of Spirodihydrobenzofuran Analogues of the Natural Product Filifolinol
Martin Becerra‐Ruiz, Antonio Galdámez, Brenda Modak and Marcelo Vilches‐Herrera(s)
ChemistrySelect, 2020, 5, 15175
DOI: 10.1002/slct.202003580

Investigation of Stepwise and Stoichiometric Palladium-Mediated ortho-C–H Bond Arylation and Alkylation of 9(10H)-Acridinone
Jean-Ho Chu, Zhe-Hong Su, Ko-Wang Yen and Hsuan-I Chien
Organometallics, 2020, 39, 3168
DOI: 10.1021/acs.organomet.0c00356

Transition‐Metal‐Catalyzed Directed C−H Functionalization in/on Water
Tariq A. Shah, Tanumay Sarkar, Subhradeep Kar, Prabhat Kumar Maharana, Kangkan Talukdar and Tharmalingam Punniyamurthy
Chemistry — An Asian Journal, 2024, 19
DOI: 10.1002/asia.202300815

Molecular complexity as a driving force for the advancement of organic synthesis
Brandon A. Wright and Richmond Sarpong
Nat Rev Chem, 2024, 8, 776
DOI: 10.1038/s41570-024-00645-8

Finding Opportunities from Surprises and Failures. Development of Rhodium-Stabilized Donor/Acceptor Carbenes and Their Application to Catalyst-Controlled C–H Functionalization
Huw M. L. Davies
J. Org. Chem., 2019, 84, 12722
DOI: 10.1021/acs.joc.9b02428

Synthesis of Natural Products by C−H Functionalization of Heterocycless
Yang Zhang and Michal Szostak
Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202104278

Radical C–H Sulfonation of Arenes: Its Applications on Bioactive and DNA-Encoded Molecules
Yue Zhang, Shengdi Xia, Wen-xia Shi, Bizhen Lin, Xiao-can Su, Weiwei Lu, Xinyuan Wu, Xuan Wang, Xiaojie Lu, Ming Yan and Xue-jing Zhang
Org. Lett., 2022, 24, 7961
DOI: 10.1021/acs.orglett.2c03077

C−H Functionalization—Prediction of Selectivity in Iridium(I)‐Catalyzed Hydrogen Isotope Exchange Competition Reactions
Mégane Valero, Thomas Kruissink, Jennifer Blass, Remo Weck, Stefan Güssregen, Alleyn T. Plowright and Volker Derdau
Angewandte Chemie, 2020, 132, 5675
DOI: 10.1002/ange.201914220

Alkynyl Triazenes as Fluoroalkyne Surrogates: Regioselective Access to 4-Fluoro-2-pyridones by a Rh(III)-Catalyzed C–H Activation–Lossen Rearrangement–Wallach Reaction
Jin-Fay Tan, Carl Thomas Bormann, Kay Severin and Nicolai Cramer
ACS Catal., 2020, 10, 3790
DOI: 10.1021/acscatal.0c00499

Construction of Biologically Important Biaryl Scaffolds through Direct C–H Bond Activation: Advances and Prospects
Shuo Yuan, Junbiao Chang and Bin Yu
Top Curr Chem (Z), 2020, 378
DOI: 10.1007/s41061-020-0285-9

Imidate as the Intact Directing Group for the Cobalt-Catalyzed C–H Allylation
Ryo Tanaka, Iku Tanimoto, Masahiro Kojima, Tatsuhiko Yoshino and Shigeki Matsunaga
J. Org. Chem., 2019, 84, 13203
DOI: 10.1021/acs.joc.9b01972

Palladium-Catalyzed Late-Stage ortho-C–H Bond Aroylation of Anilines Using 4-Methoxy-2-pyridinyl as a Removable Directing Group
Jean-Ho Chu, Meng-Fan Chiang, Chin-Wei Li, Zhe-Hong Su, Shao-Chi Lo and Ming-Jung Wu
Organometallics, 2019, 38, 2105
DOI: 10.1021/acs.organomet.9b00119

Assembly of 2-Substituted Tetrahydroquinolines from ortho-Methylbenzenesulfamides and Dienes, Using a C(sp3)–H Activation/Annulation Sequence
Iván Huertas-Morales, Borja Cendón, Domingo Costa, José Luis Mascareñas and Moisés Gulías
Org. Lett., 2024, 26, 7789
DOI: 10.1021/acs.orglett.4c02292

Efficient Amination of Activated and Non‐Activated C(sp3)−H Bonds with a Simple Iron–Phenanthroline Catalyst
Lucie Jarrige, Zijun Zhou, Marcel Hemming and Eric Meggers
Angewandte Chemie, 2021, 133, 6384
DOI: 10.1002/ange.202013687

Rhodium(III)‐Catalyzed Synthesis of Skipped Enynes via C(sp3)–H Alkynylation of Terminal Alkenes
Franco Della‐Felice, Margherita Zanini, Xiaoming Jie, Eric Tan and Antonio M. Echavarren
Angew Chem Int Ed, 2021, 60, 5693
DOI: 10.1002/anie.202014877

Asymmetric Total Synthesis of Sarpagine and Koumine Alkaloids
Zhao Yang, Qiuyuan Tan, Yan Jiang, Jiaojiao Yang, Xiaojiao Su, Zhen Qiao, Wenqiang Zhou, Ling He, Hanyue Qiu and Min Zhang
Angew Chem Int Ed, 2021, 60, 13105
DOI: 10.1002/anie.202102416

Gold(III) Auracycles Featuring C(sp3)‐Au‐C(sp2) Bonds: Synthesis and Mechanistic Insights into the Cycloauration Step
Jorge A. González, Andrés Arribas, Puyang Tian, Sergio Díaz‐Alonso, José Luis Mascareñas, Fernando López and Cristina Nevado
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202402798

Spiro[indene-1,4′-oxa-zolidinones] Synthesis via Rh(III)-Catalyzed Coupling of 4-Phenyl-1,3-oxazol-2(3H)-ones with Alkynes: A Redox-Neutral Approach
Zhongsu Liu, Wenjing Zhang, Shan Guo and Jin Zhu
J. Org. Chem., 2019, 84, 11945
DOI: 10.1021/acs.joc.9b01804

Substrate‐Rhodium Cooperativity in Photoinducedortho‐Alkynylation of Arenes
Argha Saha, Animesh Ghosh, Srimanta Guin, Sanjib Panda, Dibya Kanti Mal, Abhirup Majumdar, Munetaka Akita and Debabrata Maiti
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202210492

Palladium (0)-catalyzed C(sp)-H oxygenation with carboxylic acids
Jia-Yuan Yong, Huu-Manh Vu, Xu-Qin Li and Ai-Jun Gong
Tetrahedron, 2020, 76, 130969
DOI: 10.1016/j.tet.2020.130969

Skeletal Editing by Hypervalent Iodine Mediated Nitrogen Insertion
Anjali Gupta, Pratibha Bhatti, Joydev K. Laha and Srimanta Manna
Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202401993

Skeletal Editing of (Hetero)Arenes Using Carbenes
Zhaohong Liu, Paramasivam Sivaguru, Yongquan Ning, Yong Wu and Xihe Bi
Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202301227

Azolation of Benzylic C–H Bonds via Photoredox-Catalyzed Carbocation Generation
Mrinmoy Das, Leila Zamani, Christopher Bratcher and Patricia Z. Musacchio
J. Am. Chem. Soc., 2023, 145, 3861
DOI: 10.1021/jacs.2c12850

Rhodium(III)‐Catalyzed Synthesis of Skipped Enynes via C(sp3)–H Alkynylation of Terminal Alkenes
Franco Della‐Felice, Margherita Zanini, Xiaoming Jie, Eric Tan and Antonio M. Echavarren
Angewandte Chemie, 2021, 133, 5757
DOI: 10.1002/ange.202014877

C–H Bonds as Functional Groups: Simultaneous Generation of Multiple Stereocenters by Enantioselective Hydroxylation at Unactivated Tertiary C–H Bonds
Andrea Palone, Guillem Casadevall, Sergi Ruiz-Barragan, Arnau Call, Sílvia Osuna, Massimo Bietti and Miquel Costas
J. Am. Chem. Soc., 2023, 145, 15742
DOI: 10.1021/jacs.2c10148

Photoinduced meta-Selective C–H Oxygenation of Arenes
Wajid Ali, Argha Saha, Haibo Ge and Debabrata Maiti
JACS Au, 2023, 3, 1790
DOI: 10.1021/jacsau.3c00231

Intramolecular C(sp3)–H Bond Oxygenation by Transition‐Metal Acylnitrenoids
Yuqi Tan, Shuming Chen, Zijun Zhou, Yubiao Hong, Sergei Ivlev, K. N. Houk and Eric Meggers
Angewandte Chemie, 2020, 132, 21890
DOI: 10.1002/ange.202009335

Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)–H Bonds Enabled by Cobalt Catalysis
Ming-Zhu Lu, Xin Ding, Changdong Shao, Zhengsong Hu, Haiqing Luo, Sanjun Zhi, Huayou Hu, Yuhe Kan and Teck-Peng Loh
Org. Lett., 2020, 22, 2663
DOI: 10.1021/acs.orglett.0c00631

Asymmetric Total Synthesis of TAN-1085 Facilitated by Pd-Catalyzed Atroposelective C–H Olefination
Jun Fan, Qi-Jun Yao, Yan-Hua Liu, Gang Liao, Shuo Zhang and Bing-Feng Shi
Org. Lett., 2019, 21, 3352
DOI: 10.1021/acs.orglett.9b01099

Remote steric control for undirected meta -selective C–H activation of arenes
Boobalan Ramadoss, Yushu Jin, Sobi Asako and Laurean Ilies
Science, 2022, 375, 658
DOI: 10.1126/science.abm7599

Iron-Catalyzed Amination of Strong Aliphatic C(sp3)–H Bonds
Sandip Kumar Das, Satyajit Roy, Hillol Khatua and Buddhadeb Chattopadhyay
J. Am. Chem. Soc., 2020, 142, 16211
DOI: 10.1021/jacs.0c07810

A C–H Functionalization Strategy Enables an Enantioselective Formal Synthesis of (−)-Aflatoxin B2
Nicholas A. Falcone, Aaron T. Bosse, Hojoon Park, Jin-Quan Yu, Huw M. L. Davies and Erik J. Sorensen
Org. Lett., 2021, 23, 9393
DOI: 10.1021/acs.orglett.1c03502

Advancing the Logic of Chemical Synthesis: C−H Activation as Strategic and Tactical Disconnections for C−C Bond Construction
Nelson Y. S. Lam, Kevin Wu and Jin‐Quan Yu
Angew Chem Int Ed, 2021, 60, 15767
DOI: 10.1002/anie.202011901

Catalyst-Controlled Intermolecular Homobenzylic C(sp3)–H Amination for the Synthesis of β-Arylethylamines
Erwan Brunard, Vincent Boquet, Tanguy Saget, E. Daiann Sosa Carrizo, Marie Sircoglou and Philippe Dauban
J. Am. Chem. Soc., 2024, 146, 5843
DOI: 10.1021/jacs.3c10964

Cobalt-catalyzed atroposelective C−H activation/annulation to access N−N axially chiral frameworks
Tong Li, Linlin Shi, Xinhai Wang, Chen Yang, Dandan Yang, Mao-Ping Song and Jun-Long Niu
Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-40978-4

Iridium‐Catalyzed Electrooxidative Annulation of Naphthol with Acrylate via C−H Bond Activation for the Synthesis of Naphtho[1,8‐bc]furan
Nilam Patil, Debarati Das and Bhalchandra M. Bhanage
Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400361

Synthesis of Cytogenin Analogues by C(sp2)–H Functionalization under Ruthenium(II) Catalysis, and DFT Analysis
Ashish Joshi, Lilesh Rambhai Chavada, Mridula Choudhary, Dhruvilkumar Patel, Priyanka Mishra, Sneha Patil, Balasubramanian Sridhar, Saurabh Kumar Singh and Ashok Kumar Pandey
Synlett, 2025, 36, 2316
DOI: 10.1055/a-2564-5919

Preparative Scale Applications of C−H Activation in Medicinal Chemistry
Rita de Jesus, Kerstin Hiesinger and Manuel van Gemmeren
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202306659

Benzoxazole or Benzothiazole as an Innate Directing Group for Palladium- and Ruthenium-Catalyzed Complementary C–H Arylation: Functionalization of Biorelevant Heterocyclic Scaffolds
Mohit Maingle, Steeva Sunny, Loddipalle Sheeba, Firojkhan Rajekhan Pathan and Kapileswar Seth
Synthesis, 2024, 56, 312
DOI: 10.1055/a-2193-4804

Selective Functionalization of Benzene Ring via Carbene‐Initiated [4,5]‐Rearrangement
Xuerong Wang, Chuang Mei, Yulu Song, Fengyi Liu, Hongyan Yang, Yao Lei and Jiarong Shi
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202507149

Metal-Catalyzed C–H Bond Oxidation in the Total Synthesis of Natural and Unnatural Products
Victor C. S. Santana, Milena C. V. Fernandes, Isadora Cappuccelli, Ana Carolina G. Richieri and Emilio C. de Lucca Jr
Synthesis, 2022, 54, 5337
DOI: 10.1055/a-1918-4338

Direct Assembly of Vinyl Fluorinated Isoquinolines Via Rh(III)-Catalyzed [4 + 2] Annulation
Yi Luo, Yang-Hao Zeng and Lin Dong
J. Org. Chem., 2023, 88, 10789
DOI: 10.1021/acs.joc.3c00826

Methylene C(sp3)−H Arylation Enables the Stereoselective Synthesis and Structure Revision of Indidene Natural Products
Anton Kudashev, Stefania Vergura, Marco Zuccarello, Thomas Bürgi and Olivier Baudoin
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202316103

Cp*Rh(III)-Catalyzed Regioselective C(sp3)–H Methylation of 8-Methylquinolines with Organoborons
Rakesh Kumar, Ritika Sharma, Rohit Kumar and Upendra Sharma
Org. Lett., 2020, 22, 305
DOI: 10.1021/acs.orglett.9b04331

Regioselective and Chemodivergent Synthesis of Azulenolactones and Azulenolactams from Rhodium(III)‐Catalyzed Reactions of Azulenecarboxamides with Sulfoxonium Ylides
Seung Cheol Lee, Jeong‐Yu Son, Jin Young Kim, Hyeonsik Eom, Seong Bin Jang and Phil Ho Lee
Adv Synth Catal, 2021, 363, 512
DOI: 10.1002/adsc.202001082

Mechanistic Insights into the Chemo- and Regio-Selective B(C6F5)3 Catalyzed C–H Functionalization of Phenols with Diazoesters
Qi Zhang, Xiao-Fei Zhang, Mo Li, Cheng Li, Jia-Qin Liu, Yuan-Ye Jiang, Xin Ji, Lu Liu and Yu-Cheng Wu
J. Org. Chem., 2019, 84, 14508
DOI: 10.1021/acs.joc.9b02035

Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs
Jongwoo Son
Beilstein J. Org. Chem., 2021, 17, 1733
DOI: 10.3762/bjoc.17.122

Understanding the Role of Solvents and Spin–Orbit Coupling in an Oxygen‐Assisted SN2‐Type Oxidative Transmetalation Reaction
Boyli Ghosh, Ambar Banerjee and Ankan Paul
Chemistry A European J, 2019, 25, 16606
DOI: 10.1002/chem.201903281

Efficient Amination of Activated and Non‐Activated C(sp3)−H Bonds with a Simple Iron–Phenanthroline Catalyst
Lucie Jarrige, Zijun Zhou, Marcel Hemming and Eric Meggers
Angew Chem Int Ed, 2021, 60, 6314
DOI: 10.1002/anie.202013687

Acylsilanes as Weakly Coordinating Directing Groups for Metal-Catalyzed C–H Functionalization
Rowan L. Pilkington and Daniel L. Priebbenow
ACS Catal., 2025, 15, 6881
DOI: 10.1021/acscatal.5c00794

Expanding chemical space by para-C−H arylation of arenes
Sudip Maiti, Yingzi Li, Sheuli Sasmal, Srimanta Guin, Trisha Bhattacharya, Goutam Kumar Lahiri, Robert S. Paton and Debabrata Maiti
Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-31506-x

Synthetic studies towards arcutinidine: An alternative strategy for construction of the complete carbon framework
Xiaoqing Wu, Wei Nie, Min Fu, Xiao-Yu Liu, Fei Xue and Yong Qin
Tetrahedron, 2021, 86, 132092
DOI: 10.1016/j.tet.2021.132092

N‐Oxide‐Catalyzed Six‐Membered Ring Bromo‐Etherification of ϵ‐Alkenyl Alcohols
Yuki Hoshino, Honoka Kasahara, Ryusei Marushima and Katsuhiko Moriyama
Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202401209

Enantioselective para‐C(sp2)−H Functionalization of Alkyl Benzene Derivatives via Cooperative Catalysis of Gold/Chiral Brønsted Acid**
Xun‐Shen Liu, Zhiqiong Tang, Zhi‐Yao Si, Zhikun Zhang, Lei Zhao and Lu Liu
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202208874

Rh(III) Catalyzed Redox-Neutral C–H Activation/[5 + 2] Annulation of Aroyl Hydrazides and Sulfoxonium Ylides: Synthesis of Benzodiazepinones
Pothapragada S. K. Prabhakar Ganesh, Perumal Muthuraja and Purushothaman Gopinath
Org. Lett., 2023, 25, 8361
DOI: 10.1021/acs.orglett.3c03495

Bioinspired Palladium‐Catalyzed Intramolecular C(sp3)−H Activation for the Collective Synthesis of Proline Natural Products
Quan‐Zhe Li, Si‐Hua Hou, Jun‐Chen Kang, Peng‐Fei Lian, Yu Hao, Chao Chen, Jia Zhou, Tong‐Mei Ding and Shu‐Yu Zhang
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202207088

Selective Benzylic CH‐Borylations by Tandem Cobalt Catalysis
Pradip Ghosh, Roland Schoch, Matthias Bauer and Axel Jacobi von Wangelin
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202110821

Achiral Cp*Rh(III)/Chiral Lewis Base Cooperative Catalysis for Enantioselective Cyclization via C–H Activation
Takumaru Kurihara, Masahiro Kojima, Tatsuhiko Yoshino and Shigeki Matsunaga
J. Am. Chem. Soc., 2022, 144, 7058
DOI: 10.1021/jacs.2c01223

Half-Sandwich d6-Metal (CoIII, RhIII, IrIII, RuII)-Catalyzed Enantioselective C–H Activation
Pu-Fan Qian, Jun-Yi Li, Yi-Bo Zhou, Tao Zhou and Bing-Feng Shi
SynOpen, 2023, 07, 466
DOI: 10.1055/a-2167-8298

Palladium‐Catalyzed Cascade Cyclization for the Synthesis of Fused Benzo‐Aza‐Oxa‐[5‐6‐5] Tetracycles
Chao Liu, Xiangwen Tan, Lingzhi Zhan, Yaru Jing, Wanqing Wu, Zhuofeng Ke and Huanfeng Jiang
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202215020

Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis
Fan Wu, Jing Zhang, Fuhang Song, Sanshan Wang, Hui Guo, Qi Wei, Huanqin Dai, Xiangyin Chen, Xuekui Xia, Xueting Liu, Lixin Zhang, Jin-Quan Yu and Xiaoguang Lei
ACS Cent. Sci., 2020, 6, 928
DOI: 10.1021/acscentsci.0c00122

Iron-catalyzed synthesis of N-heterocycles via intermolecular and intramolecular cyclization reactions: A review
Maria Sohail, Muhammad Bilal, Tahir Maqbool, Nasir Rasool, Muhammad Ammar, Sajid Mahmood, Ayesha Malik, Muhammad Zubair and Ghulam Abbas Ashraf
Arabian Journal of Chemistry, 2022, 15, 104095
DOI: 10.1016/j.arabjc.2022.104095

Cobalt‐Catalyzed Enantioselective C−H Carbonylation towards Chiral Isoindolinones
Ming‐Ya Teng, Yong‐Jie Wu, Jia‐Hao Chen, Fan‐Rui Huang, De‐Yang Liu, Qi‐Jun Yao and Bing‐Feng Shi
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202318803

Recent Advancements in Allylic C(sp3)–H Functionalization of Olefins Catalyzed by Rh(III) or Ir(III) Complexes
Ramasamy Manoharan and Masilamani Jeganmohan
Eur J Org Chem, 2020, 2020, 7304
DOI: 10.1002/ejoc.202000936

Direct Construction of Diverse Polyheterocycles Bearing Pyrrolidinediones via Rh(III)‐Catalyzed Cascade C−H Activation/Spirocyclization
Shreedhar Devkota, Ha‐Jin Lee, Sung Hong Kim and Yong Rok Lee
Adv Synth Catal, 2019, 361, 5587
DOI: 10.1002/adsc.201901019

Transition Metal Catalyzed Free‐Amine (−NH2) Directed C−H Bond Activation and Functionalization for Biaryl Frameworks
Prasanjit Ghosh, Deepan Chowdhury, Suman Dana and Mahiuddin Baidya
The Chemical Record, 2021, 21, 3795
DOI: 10.1002/tcr.202100158

Skeletal Editing through Cycloaddition and Subsequent Cycloreversion Reactions
Pengwei Xu and Armido Studer
Acc. Chem. Res., 2025, 58, 647
DOI: 10.1021/acs.accounts.4c00813

Total Synthesis of Daphenylline via Diels–Alder Cycloaddition and Rhodium-Catalyzed C–H Alkynylation
Wei Chen, Aohang Liu, Jinwei Huang, Pengfei Yu, Huaxuan Zhang, Huilin Li, Xingang Xie, Gaoyuan Zhao and Xuegong She
Org. Lett., 2025, 27, 7423
DOI: 10.1021/acs.orglett.5c02227

Iridium complex immobilization on covalent organic framework for effective C—H borylation
Harsh Vardhan, Yanxiong Pan, Zhongyu Yang, Gaurav Verma, Ayman Nafady, Abdullah M. Al-Enizi, Tawfiq M. Alotaibi, Omar A. Almaghrabi and Shengqian Ma
APL Materials, 2019, 7
DOI: 10.1063/1.5122674

Gold‐Catalyzed Synthesis of Fluorenones via Intramolecular C–H Arylation
Osvaldo Felipe López‐Saladino, Diego Dusso, Howard Díaz‐Salazar, Brayan Alberto Martínez‐González, Miguel Angel Rosas‐Ortega and Susana Porcel
Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.70015

Unactivated C(sp3)-H functionalization via vinyl cations
Xi-Jia Liu, Yin Xu, Conghui Tang, Peng-Cheng Qian and Long-Wu Ye
Sci. China Chem., 2022, 65, 20
DOI: 10.1007/s11426-021-1117-2

Advances in the catalyst- and reagent-controlled site-divergent intermolecular functionalization of C(sp 3)–H bonds
Alexander Fawcett
Pure and Applied Chemistry, 2020, 92, 1987
DOI: 10.1515/pac-2020-0803

Enantioselective para‐C(sp2)−H Functionalization of Alkyl Benzene Derivatives via Cooperative Catalysis of Gold/Chiral Brønsted Acid**
Xun‐Shen Liu, Zhiqiong Tang, Zhi‐Yao Si, Zhikun Zhang, Lei Zhao and Lu Liu
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202208874

Chiral Transient Directing Groups in Transition-Metal-Catalyzed Enantioselective C–H Bond Functionalization
Maria I. Lapuh, Sara Mazeh and Tatiana Besset
ACS Catal., 2020, 10, 12898
DOI: 10.1021/acscatal.0c03317

Manganese-Catalyzed C(sp2)–H Borylation of Furan and Thiophene Derivatives
Luke Britton, Maciej Skrodzki, Gary S. Nichol, Andrew P. Dominey, Piotr Pawluć, Jamie H. Docherty and Stephen P. Thomas
ACS Catal., 2021, 11, 6857
DOI: 10.1021/acscatal.1c01563

Asymmetric Synthesis of Enantiopure Pyrrolidines by C(sp3)−H Amination of Hydrocarbons
Yanis Lazib, Pascal Retailleau, Tanguy Saget, Benjamin Darses and Philippe Dauban
Angewandte Chemie, 2021, 133, 21876
DOI: 10.1002/ange.202107898

Primary amides: Sustainable weakly coordinating groups in transition metal-catalyzed C–H bond functionalization reactions
Rima Thakur, Yogesh Jaiswal and Amit Kumar
Tetrahedron, 2021, 93, 132313
DOI: 10.1016/j.tet.2021.132313

The Ketone-Amine-Alkyne (KA2) coupling reaction: Transition metal-catalyzed synthesis of quaternary propargylamines
Leandros P. Zorba and Georgios C. Vougioukalakis
Coordination Chemistry Reviews, 2021, 429, 213603
DOI: 10.1016/j.ccr.2020.213603

A Review on Oxidative Gold‐Catalyzed C‐H Arylation of Arenes – Challenges and Opportunities
Christoph Fricke, William B. Reid and Franziska Schoenebeck
Eur J Org Chem, 2020, 2020, 7119
DOI: 10.1002/ejoc.202000856

Catalytic Asymmetric C(sp3)–H Carbene Insertion Approach to Access Enantioenriched 3-Fluoroalkyl 2,3-Dihydrobenzofurans
Xinyu Zhang, Paramasivam Sivaguru, Giuseppe Zanoni, Xinyue Han, Minghui Tong and Xihe Bi
ACS Catal., 2021, 11, 14293
DOI: 10.1021/acscatal.1c04523

Spatial Anion Control on Palladium for Mild C–H Arylation of Arenes
Jyoti Dhankhar, Elisa González-Fernández, Chao-Chen Dong, Tufan K. Mukhopadhyay, Anthony Linden and Ilija Čorić
J. Am. Chem. Soc., 2020, 142, 19040
DOI: 10.1021/jacs.0c09611

Streamlined Ruthenium(II) Catalysis for One-Pot 2-fold Unsymmetrical C–H Olefination of (Hetero)Arenes
Anup Mandal, Gunjan Mehta, Suman Dana and Mahiuddin Baidya
Org. Lett., 2019, 21, 5879
DOI: 10.1021/acs.orglett.9b02008

Palladium‐Catalyzed Cascade Cyclization for the Synthesis of Fused Benzo‐Aza‐Oxa‐[5‐6‐5] Tetracycles
Chao Liu, Xiangwen Tan, Lingzhi Zhan, Yaru Jing, Wanqing Wu, Zhuofeng Ke and Huanfeng Jiang
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202215020

Chameleon-like Behavior of the Directing Group in the Rh(III)-Catalyzed Regioselective C–H Amidation of Indole: An Experimental and Computational Study
Jinquan Zhang, Hujun Xie, Huajian Zhu, Shuaizhong Zhang, Madhava Reddy Lonka and Hongbin Zou
ACS Catal., 2019, 9, 10233
DOI: 10.1021/acscatal.9b02512

Recent Advances in Saturated N-Heterocycle C–H Bond Functionalization for Alkylated N-Heterocycle Synthesis
Cameron H. M. Zheng and Laurel L. Schafer
Synthesis, 2025, 57, 522
DOI: 10.1055/s-0043-1775377

Design, Synthesis, and Evaluation of Extended C4–Symmetric Dirhodium Tetracarboxylate Catalysts
Zachary J. Garlets, Yannick T. Boni, Jack C. Sharland, Randall P. Kirby, Jiantao Fu, John Bacsa and Huw M. L. Davies
ACS Catal., 2022, 12, 10841
DOI: 10.1021/acscatal.2c03041

Rhodium‐Catalyzed C−H Activation/Annulation of Aryl Hydroxamates with Benzothiadiazol‐Containing Acetylenes: Access to Isoquinoline‐Bridged Donor‐Acceptor Luminophores
Pavel S. Gribanov, Daria V. Vorobyeva, Sergey D. Tokarev, Dmitry A. Petropavlovskikh, Dmitry A. Loginov, Sergey E. Nefedov, Fedor M. Dolgushin and Sergey N. Osipov
Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202101572

Homoleptic Lanthanide Amide Catalysts for Organic Synthesis: Experiment and Theory
Rachel D. Dicken, Alessandro Motta and Tobin J. Marks
ACS Catal., 2021, 11, 2715
DOI: 10.1021/acscatal.0c04882

Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2H)‐ones as Potent Antitumor Agents
Mengyao Bian, Lei Ma, Min Wu, Liexin Wu, Hui Gao, Wei Yi, Chao Zhang and Zhi Zhou
ChemPlusChem, 2020, 85, 405
DOI: 10.1002/cplu.201900616

Rhodium(III)-Catalyzed Asymmetric C–H Activation of N-Methoxybenzamide with Quinone and Its Application in the Asymmetric Synthesis of a Dihydrolycoricidine Analogue
Xiaoqiang Yan, Peng Zhao, Hao Liang, Hui Xie, Jijun Jiang, Shaohua Gou and Jun Wang
Org. Lett., 2020, 22, 3219
DOI: 10.1021/acs.orglett.0c01002

Anwendungen der C−H‐Aktivierung im präparativen Maßstab in der medizinischen Chemie
Rita de Jesus, Kerstin Hiesinger and Manuel van Gemmeren
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202306659

Cobalt-Catalyzed C–H Bond Functionalization: a Personal Account
Aleksandrs Cizikovs, Lukass T. Lukasevics, Paula A. Zagorska and Liene Grigorjeva
Synlett, 2025, 36, 1659
DOI: 10.1055/s-0043-1775473

Intermolecular C‐Arylation of 2‐Amidobiphenyls Overcoming Intramolecular N‐Arylation
Ankita Bal, Saikat Maiti and Prasenjit Mal
Asian J Org Chem, 2020, 9, 1783
DOI: 10.1002/ajoc.202000439

Diaryldiazoketones as Effective Carbene Sources for Highly Selective Rh(II)-Catalyzed Intermolecular C–H Functionalization
Terrence-Thang H. Nguyen, Aaron T. Bosse, Duc Ly, Camila A. Suarez, Jiantao Fu, Kristin Shimabukuro, Djamaladdin G. Musaev and Huw M. L. Davies
J. Am. Chem. Soc., 2024, 146, 8447
DOI: 10.1021/jacs.3c14552

Iridium-Catalyzed Direct C–H Amidation Producing Multicolor Fluorescent Molecules Emitting Blue-to-Red Light and White Light
Soon-Hyeok Hwang and Tae-Lim Choi
Org. Lett., 2020, 22, 2935
DOI: 10.1021/acs.orglett.0c00618

Recent Advances in Synthetic Methods by Photocatalytic Single-Electron Transfer Chemistry of Pyridine N-Oxides
Vanaparthi Satheesh and Yongming Deng
J. Org. Chem., 2024, 89, 11864
DOI: 10.1021/acs.joc.4c01453

Application of Conjugated Carbonyls in the Synthesis of Heterocycles via Oxidative Cycloaddition and Cyclization Reactions
Avik Kumar Bagdi, Paramita Pattanayak, Suvam Paul, Mousree Mitra, Tathagata Choudhuri and Amir Sohel Sheikh
Adv Synth Catal, 2020, 362, 5601
DOI: 10.1002/adsc.202000970

The direct C(sp2)-H functionalization and coupling of aromatic N-heterocycles with (hetero)aryl bromides by [PdX2(imidazolidin-2-ylidene)(Py)] catalysts
Murat Kaloğlu, Ichraf Slimani, Namık Özdemir, Nevin Gürbüz, Naceur Hamdi and İsmail Özdemir
Journal of Organometallic Chemistry, 2021, 951, 122013
DOI: 10.1016/j.jorganchem.2021.122013

Waste-minimized C(sp3)-H activation for the preparation of fused N-heterocycles
Nihad Salameh, Francesco Minio, Gabriele Rossini, Assunta Marrocchi and Luigi Vaccaro
Green Synthesis and Catalysis, 2023, 4, 240
DOI: 10.1016/j.gresc.2023.02.004

From Reactivity and Regioselectivity to Stereoselectivity: An Odyssey of Designing PIP Amine and Related Directing Groups for C—H Activation
Qi Zhang and Bing‐Feng Shi
Chin. J. Chem., 2019, 37, 647
DOI: 10.1002/cjoc.201900090

Directing Group Assisted Unsymmetrical Multiple Functionalization of Arene C−H Bonds
Koushik Ghosh, Raja K. Rit, Majji Shankar, Kallol Mukherjee and Akhila K. Sahoo
The Chemical Record, 2020, 20, 1017
DOI: 10.1002/tcr.202000063

Pd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature
Mu-Yi Chen, Xavier Pannecoucke, Philippe Jubault and Tatiana Besset
Org. Lett., 2020, 22, 7556
DOI: 10.1021/acs.orglett.0c02750

Accessing 7,8-Dihydroquinoline-2,5-diones via Rh-Catalyzed Olefinic C–H Activation/[4+2] Cyclization
Xueqing Liu, Sijia Shi, Wenqian Ding, Zhiyue He, Yu Shen, Yong Nian and Xiaowei Wu
Org. Lett., 2024, 26, 5136
DOI: 10.1021/acs.orglett.4c01536

Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(sp3)–H Bonds
Bin Liu, Andrew M. Romine, Camille Z. Rubel, Keary M. Engle and Bing-Feng Shi
Chem. Rev., 2021, 121, 14957
DOI: 10.1021/acs.chemrev.1c00519

Photochemically Mediated Ring Expansion of Indoles and Pyrroles with Chlorodiazirines: Synthetic Methodology and Thermal Hazard Assessment
Ben W. Joynson, Graham R. Cumming and Liam T. Ball
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202305081

Palladium Catalyzed Direct Alkenylation of Dihydropyrrolo[2,1‐a]isoquinolines through the Oxidative Heck Reaction
Hai‐Lei Cui, Si‐Wei Liu and Xue Xiao
Eur J Org Chem, 2020, 2020, 5729
DOI: 10.1002/ejoc.202000959

Efficient and Divergent Total Synthesis of (−)-Epicoccin G and (−)-Rostratin A Enabled by Double C(sp3)–H Activation
Pierre Thesmar and Olivier Baudoin
J. Am. Chem. Soc., 2019, 141, 15779
DOI: 10.1021/jacs.9b09359

Pd-Nanoparticles-Catalyzed C(sp2)–H Arylation for the Synthesis of Functionalized Heterocycles: Recent Progress and Prospects
Steeva Sunny, Mohit Maingle, Loddipalle Sheeba, Firojkhan Rajekhan Pathan, Gowri Sankar J., Harika Juloori, Sainath Ganesh Gadewar and Kapileswar Seth
Synthesis, 2024, 56, 611
DOI: 10.1055/a-2060-3488

Multifaceted Hidden Catalysis Revealed by Mechanistic Analysis of FeBr3‐Catalysed Arene Borylation
Luke Britton, Andrew D. Bage, Sarah L. McOnie and Stephen P. Thomas
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202423929

A radical crossover into C–H functionalization
Grace A. Lutovsky and Tehshik P. Yoon
Chem Catalysis, 2022, 2, 221
DOI: 10.1016/j.checat.2022.01.019

Recent Advances in C–H Activation for the Synthesis of π-Extended Materials
Iain A. Stepek and Kenichiro Itami
ACS Materials Lett., 2020, 2, 951
DOI: 10.1021/acsmaterialslett.0c00206

Sterically Controlled C−H Olefination of Heteroarenes
Hao Chen, Mirxan Farizyan, Francesca Ghiringhelli and Manuel van Gemmeren
Angewandte Chemie, 2020, 132, 12311
DOI: 10.1002/ange.202004521

Di-tert-butyl peroxide-mediated carbon–heteroatom bond formation reactions
Ravi Varala, Kamsali Murali Mohan Achari, Mohammed Mujahid Alam and Seella Ramanaiah
Chem Heterocycl Comp, 2025, 61, 1
DOI: 10.1007/s10593-025-03392-w

Acid‐Cooperative Transition Metal‐Catalysed Oxygen‐Atom‐Transfer: Ruthenium‐Catalysed C−H Oxygenation
Daiki Doiuchi, Nanako Shimoda, Koushi Okazaki and Tatsuya Uchida
Adv Synth Catal, 2024, 366, 2026
DOI: 10.1002/adsc.202301453

Transition Metal‐Catalyzed Enantioselective C−H Functionalization via Chiral Transient Directing Group Strategies
Gang Liao, Tao Zhang, Zhi‐Keng Lin and Bing‐Feng Shi
Angewandte Chemie, 2020, 132, 19941
DOI: 10.1002/ange.202008437

Ni‐Catalyzed Chelation‐AssistedDirect Functionalization of Inert C—H Bonds
Yan‐Hua Liu, Yu‐Nong Xia and Bing‐Feng Shi
Chin. J. Chem., 2020, 38, 635
DOI: 10.1002/cjoc.201900468

Selectivity Switch in Non‐Directed Palladium‐Catalyzed C−H Olefination of Chlorobenzene Derivatives
Jeanne Fichez, Maria I. Lapuh, Lina Truong, Hassan Oulyadi, Floris Buttard and Tatiana Besset
Adv Synth Catal, 2024, 366, 2811
DOI: 10.1002/adsc.202400316

Synthesis of (−)-Mitrephorone A via a Bioinspired Late Stage C–H Oxidation of (−)-Mitrephorone B
Lukas Anton Wein, Klaus Wurst, Peter Angyal, Lara Weisheit and Thomas Magauer
J. Am. Chem. Soc., 2019, 141, 19589
DOI: 10.1021/jacs.9b11646

Forging C−heteroatom bonds by transition-metal-catalyzed enantioselective C–H functionalization
Qi Zhang, Le-Song Wu and Bing-Feng Shi
Chem, 2022, 8, 384
DOI: 10.1016/j.chempr.2021.11.015

Hydrogen-bond-acceptor ligands enable distal C(sp3)–H arylation of free alcohols
Daniel A. Strassfeld, Chia-Yu Chen, Han Seul Park, D. Quang Phan and Jin-Quan Yu
Nature, 2023, 622, 80
DOI: 10.1038/s41586-023-06485-8

Catalytic C−H Functionalization of Unreactive Furan Cores in Bio‐Derived Platform Chemicals
Bogdan Y. Karlinskii and Valentine P. Ananikov
ChemSusChem, 2021, 14, 558
DOI: 10.1002/cssc.202002397

Palladium-Catalyzed Cascade Reactions for Annulative π -Extension of Indoles to Carbazoles through C–H Bond Activation
Enakshi Dinda, Samir Kumar Bhunia and Ranjan Jana
COC, 2020, 24, 2612
DOI: 10.2174/1385272824999200817170058

Traceless Directing Groups in Sustainable Metal-Catalyzed C–H Activation
Athanasios Zarkadoulas, Ioanna Zgouleta, Nikolaos V. Tzouras and Georgios C. Vougioukalakis
Catalysts, 2021, 11, 554
DOI: 10.3390/catal11050554

Catalyst- and Solvent-Free Coupling of 2-Methyl Quinazolinones and Isatins: An Environmentally Benign Access of Diastereoselective Schizocommunin Analogues
Bhanwar Kumar Malviya, Karandeep Singh, Pradeep K. Jaiswal, Monika Shukla, Ved Prakash Verma, Murugesan Vanangamudi, Amanpreet Kaur Jassal, Pinki B. Punjabi and Siddharth Sharma
ACS Omega, 2019, 4, 12146
DOI: 10.1021/acsomega.9b01514

Total Synthesis of (+)-Cyclobutastellettolide B
Zhongchao Zhang, Sijia Chen, Fu Tang, Kai Guo, Xin-Ting Liang, Jun Huang and Zhen Yang
J. Am. Chem. Soc., 2021, 143, 18287
DOI: 10.1021/jacs.1c08880

Catalytic Selective Metal-Free Cross-Coupling of Heteroaromatic N-Oxides with Organosilanes
Mahesh Puthanveedu, Vasiliki Polychronidou and Andrey P. Antonchick
Org. Lett., 2019, 21, 3407
DOI: 10.1021/acs.orglett.9b01141

Ligand-Controlled Orthogonal Selectivity between δ and γ Positions of Long-Chain Picolinamides
Soumya Kumar Sinha, Nupur Goswami, Yingzi Li, Suman Maji, Dineshkumar Raja, Anjana Suseelan Sarala, Srimanta Guin, Robert S. Paton and Debabrata Maiti
ACS Catal., 2024, 14, 12681
DOI: 10.1021/acscatal.4c03126

Cobalt-Catalyzed Enantioselective C–H Annulation of Benzylamines with Alkynes: Application to the Modular and Asymmetric Syntheses of Bioactive Molecules
Yong-Jie Wu, Jia-Hao Chen, Ming-Ya Teng, Xiang Li, Tian-Yu Jiang, Fan-Rui Huang, Qi-Jun Yao and Bing-Feng Shi
J. Am. Chem. Soc., 2023, 145, 24499
DOI: 10.1021/jacs.3c10714

Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes
Kevin Hung, Matthew L. Condakes, Luiz F. T. Novaes, Stephen J. Harwood, Takahiro Morikawa, Zhi Yang and Thomas J. Maimone
J. Am. Chem. Soc., 2019, 141, 3083
DOI: 10.1021/jacs.8b12247

para‐Selective Arylation of Arenes: A Direct Route to Biaryls by Norbornene Relay Palladation
Uttam Dutta, Sandip Porey, Sandeep Pimparkar, Astam Mandal, Jagrit Grover, Adithyaraj Koodan and Debabrata Maiti
Angewandte Chemie, 2020, 132, 21017
DOI: 10.1002/ange.202005664

tert‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations
Ravi Varala, Vittal Seema, Mohamed Hussein, Mohammed Mujahid Alam and Durga Prasad Beda
ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202401937

Weakly coordinating group directed rhodium-catalyzed unconventional site-selective C–H olefination of indolizines at the 8-position
Xue Feng, Jiaxin Tian, Ying Sun, Huayou Hu, Mingzhu Lu, Yuhe Kan, Danjun Fang and Chao Wang
Chinese Chemical Letters, 2021, 32, 470
DOI: 10.1016/j.cclet.2020.02.039

A Divergent Strategy for Site‐Selective Radical Disulfuration of Carboxylic Acids with Trisulfide‐1,1‐Dioxides
Zijun Wu and Derek A. Pratt
Angew Chem Int Ed, 2021, 60, 15598
DOI: 10.1002/anie.202104595

Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C–H Bond Activation
Mu-Yi Chen, Xavier Pannecoucke, Philippe Jubault and Tatiana Besset
J. Org. Chem., 2019, 84, 13194
DOI: 10.1021/acs.joc.9b01872

Alkyne Linchpin Strategy for Drug:Pharmacophore Conjugation: Experimental and Computational Realization of a Meta-Selective Inverse Sonogashira Coupling
Sandip Porey, Xinglong Zhang, Suman Bhowmick, Vikas Kumar Singh, Srimanta Guin, Robert S. Paton and Debabrata Maiti
J. Am. Chem. Soc., 2020, 142, 3762
DOI: 10.1021/jacs.9b10646

Aliphatic Nitrile Template Enabled meta-C–H Olefination of Indene Enoate Esters under Microwave Accelerating Conditions
Kurella Mounika and Gedu Satyanarayana
Org. Lett., 2024, 26, 8899
DOI: 10.1021/acs.orglett.4c03357

Prins cyclization-mediated stereoselective synthesis of tetrahydropyrans and dihydropyrans: an inspection of twenty years
Asha Budakoti, Pradip Kumar Mondal, Prachi Verma and Jagadish Khamrai
Beilstein J. Org. Chem., 2021, 17, 932
DOI: 10.3762/bjoc.17.77

Catalytic Behavior of Mono‐N‐Protected Amino‐Acid Ligands in Ligand‐Accelerated C−H Activation by Palladium(II)
Chase A. Salazar, Joseph J. Gair, Kaylin N. Flesch, Ilia A. Guzei, Jared C. Lewis and Shannon S. Stahl
Angewandte Chemie, 2020, 132, 10965
DOI: 10.1002/ange.202002484

Activity‐Directed Synthesis: A Flexible Approach for Lead Generation
George Karageorgis, Samuel Liver and Adam Nelson
ChemMedChem, 2020, 15, 1776
DOI: 10.1002/cmdc.202000524

Polarclean/Water as a Safe and Recoverable Medium for Selective C2-Arylation of Indoles Catalyzed by Pd/C
Filippo Campana, Beatrice Maria Massaccesi, Stefano Santoro, Oriana Piermatti and Luigi Vaccaro
ACS Sustainable Chem. Eng., 2020, 8, 16441
DOI: 10.1021/acssuschemeng.0c05049

Regioselective Rh(III)-Catalyzed Spiro-Cyclization and ortho-C(sp2)–H-Annulations of Secondary Aromatic Amide with Maleimide: Construction of Spiropyrrolidinetriones and Dibenzoazocinetriones
Raju Vaggu, Marella Rosi Reddy, Mohamed Asik Ali, René Grée and Saibal Das
J. Org. Chem., 2025, 90, 11216
DOI: 10.1021/acs.joc.5c01089

C−H Functionalization—Prediction of Selectivity in Iridium(I)‐Catalyzed Hydrogen Isotope Exchange Competition Reactions
Mégane Valero, Thomas Kruissink, Jennifer Blass, Remo Weck, Stefan Güssregen, Alleyn T. Plowright and Volker Derdau
Angew Chem Int Ed, 2020, 59, 5626
DOI: 10.1002/anie.201914220

Weak bonding strategies for achieving regio- and site-selective transformations
Yang Jiao, Xiao-Yang Chen and J. Fraser Stoddart
Chem, 2022, 8, 414
DOI: 10.1016/j.chempr.2021.12.012

Regioselective Dichotomy in Ru(II)-Catalyzed C–H Annulation of Aryl Pyrazolidinones with 1,3-Diynes
Geetanjali S. Sontakke, Chiranjit Ghosh, Kuntal Pal and Chandra M. R. Volla
J. Org. Chem., 2022, 87, 14103
DOI: 10.1021/acs.joc.2c01691

Enantioselective sequential Michael addition/C-H olefination/Michael reaction for the efficient collective synthesis of clavine alkaloids
Zhi-Gang Ma, Yu Hao, Wei Jiang, Xian-Yu Pan, Tong-Mei Ding, Si-Hua Hou and Shu-Yu Zhang
Cell Reports Physical Science, 2024, 5, 102112
DOI: 10.1016/j.xcrp.2024.102112

Selective Functionalization of Benzene Ring via Carbene‐Initiated [4,5]‐Rearrangement
Xuerong Wang, Chuang Mei, Yulu Song, Fengyi Liu, Hongyan Yang, Yao Lei and Jiarong Shi
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202507149

Catalytic Enantioselective Functionalizations of C–H Bonds by Chiral Iridium Complexes
Łukasz Woźniak, Jin-Fay Tan, Qui-Hien Nguyen, Adrien Madron du Vigné, Vitalii Smal, Yi-Xuan Cao and Nicolai Cramer
Chem. Rev., 2020, 120, 10516
DOI: 10.1021/acs.chemrev.0c00559

Late-stage C–H functionalization offers new opportunities in drug discovery
Lucas Guillemard, Nikolaos Kaplaneris, Lutz Ackermann and Magnus J. Johansson
Nat Rev Chem, 2021, 5, 522
DOI: 10.1038/s41570-021-00300-6

Photochromic Oxime Directing Groups for Spatially Controlled Pd-Catalyzed C–H Difunctionalization with Tandem Electrophiles
Mahmoud R. Saleh, Mahmoud Afrasi, Ajay H. Bansode, Poulami Ghosh, Dan E. Wise and Marvin Parasram
ACS Catal., 2025, 15, 16917
DOI: 10.1021/acscatal.5c05469

Access to polycyclic diazepino[5,6,7-cd]indoles from isatins via tandem 1,5-hydride transfer/cyclization
Zhonglin Wang, Longfei Li, Bin Qiu, Xiao-De An and Jian Xiao
Tetrahedron Letters, 2023, 122, 154518
DOI: 10.1016/j.tetlet.2023.154518

Rhodium‐Catalyzed Meta‐C−H Arylation of Arenes with Varied Linker Lengths: Bridging Catalytic Selectivity with Structural Diversity
Astam Mandal, Jyoti Prasad Biswas and Debabrata Maiti
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202419954

Rhodium(III)-Catalyzed Cyclopropane C–H/C–C Activation Sequence Provides Diastereoselective Access to α-Alkoxylated γ-Lactams
Benoit Audic and Nicolai Cramer
Org. Lett., 2020, 22, 5030
DOI: 10.1021/acs.orglett.0c01606

Palladium catalyzed C(sp3)–H bond activation of free carboxylic acids: An adventure of ligand evolution
Dong Li, Xiao-Bao He, Liang Jin, Xin Yu and Qi Zhang
Tetrahedron Letters, 2024, 138, 154951
DOI: 10.1016/j.tetlet.2024.154951

The meta-Selective C–H Functionalization of Phenol Derivatives Using a Nitrile-Based Directing Group
Kurella Mounika, Dasari Srinivas and Gedu Satyanarayana
J. Org. Chem., 2025, 90, 7888
DOI: 10.1021/acs.joc.5c00812

Biocatalytic, Intermolecular C−H Bond Functionalization for the Synthesis of Enantioenriched Amides
Soumitra V. Athavale, Shilong Gao, Zhen Liu, Sharath Chandra Mallojjala, Jennifer S. Hirschi and Frances H. Arnold
Angewandte Chemie, 2021, 133, 25068
DOI: 10.1002/ange.202110873

Chemodivergent Spirocyclization of 2‐Sec‐Aminobenzilidene Imidazolones: Lewis Versus Brønsted Acids Catalysis
Dmitrii S. Ivanov, Elvira R. Zaitseva, Alexander Yu. Smirnov, Dina A. Rustamova, Andrey A. Mikhaylov, Maria A. Sycheva, Darya A. Gluschenko, Nadezhda S. Baleeva and Mikhail S. Baranov
Adv Synth Catal, 2022, 364, 1587
DOI: 10.1002/adsc.202200109

Direct Integration of Phthalazinone and Succinimide Scaffolds via Rh(III)‐Catalyzed C−H Functionalization
Yong Sun Cho, Hak Do Kim, Euntaek Kim, Sang Hoon Han, Soo Bong Han, Neeraj Kumar Mishra, Young Hoon Jung, Taejoo Jeong and In Su Kim
Asian J Org Chem, 2021, 10, 202
DOI: 10.1002/ajoc.202000454

Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes
Andrew Whyte, Alexa Torelli, Bijan Mirabi, Liher Prieto, José F. Rodríguez and Mark Lautens
J. Am. Chem. Soc., 2020, 142, 9510
DOI: 10.1021/jacs.0c03246

Biomimetic synthesis of pallavicinin, neopallavicinin, pallambins A–D, pallaviambins A/B, and pallavicinolides B/C
Lijun Chen, Peng Chen, Xiwu Zhang, Yu Zhang and Yanxing Jia
Chem, 2024, 10, 2473
DOI: 10.1016/j.chempr.2024.04.003

Bifunctional reagents in organic synthesis
Huan-Ming Huang, Peter Bellotti, Jiajia Ma, Toryn Dalton and Frank Glorius
Nat Rev Chem, 2021, 5, 301
DOI: 10.1038/s41570-021-00266-5

Catalytic Metal-free Allylic C–H Amination of Terpenoids
Wei Pin Teh, Derek C. Obenschain, Blaise M. Black and Forrest E. Michael
J. Am. Chem. Soc., 2020, 142, 16716
DOI: 10.1021/jacs.0c06997

Amidyl Radical Directed γ‐C(sp3)−H Functionalization with Silyl Enol Ethers via Photoredox Catalysis
Kedong Xu, Jiawen Yang, Haitao Qin and Feng Liu
Eur J Org Chem, 2023, 26
DOI: 10.1002/ejoc.202300543

Trialkoxysilane-Induced Iridium-Catalyzed para-Selective C–H Bond Borylation of Arenes
Guodong Ju, Zhibin Huang and Yingsheng Zhao
Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-47205-8

Single-Flask Manganese(I)-Catalyzed Dienylation and Diels–Alder Cascade: Synthesis of Indole–Cyclohexene Hybrids with Anti-Inflammatory Activity
Jinhwan Park, Da Young Kim, Yeongmi Park, Joohyun Lee, Seungmin Lee, Minsuk Kim, Ki Woo Kim and Jongwoo Son
Org. Lett., 2025, 27, 8411
DOI: 10.1021/acs.orglett.5c02044

Asymmetric Ru/Cinchonine Dual Catalysis for the One-Pot Synthesis of Optically Active Phthalides from Benzoic Acids and Acrylates
Dattatraya H. Dethe, Nagabhushana C. Beeralingappa, Salman A. Siddiqui and Prakash N. Chavan
J. Org. Chem., 2022, 87, 4617
DOI: 10.1021/acs.joc.1c02961

Multiple Aromatic C–H Bond Activations by an Unsaturated Dirhenium Carbonyl Complex
Richard D. Adams, Poonam Dhull, Mark D. Smith and Jonathan D. Tedder
Inorg. Chem., 2019, 58, 2109
DOI: 10.1021/acs.inorgchem.8b03201

Copper‐Catalyzed Remote C5‐Selective Chlorination of 8‐Amidoquinolines Using Sulfonyl Chlorides as Cl Source
Han Zhang, Miao Xu, Ningning Liu and Fanzhi Yang
ChemistrySelect, 2021, 6, 2319
DOI: 10.1002/slct.202100030

Preparative‐Scale Biocatalytic Oxygenation of N‐Heterocycles with a Lyophilized Peroxygenase Catalyst
Balázs Pogrányi, Tamara Mielke, Alba Díaz‐Rodríguez, Jared Cartwright, William P. Unsworth and Gideon Grogan
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202214759

An Efficient, One-Pot Transamidation of 8-Aminoquinoline Amides Activated by Tertiary-Butyloxycarbonyl
Wengang Wu, Jun Yi, Huipeng Xu, Shuangjun Li and Rongxin Yuan
Molecules, 2019, 24, 1234
DOI: 10.3390/molecules24071234

Double 1,2-Migration of Bromine and Silicon in Directed C–H Alkynylation Reactions with Silyl-Substituted Alkynyl Bromides through an Iridium Vinylidene Intermediate
Ken Yamazaki, Sanjit K. Mahato, Yusuke Ano and Naoto Chatani
Organometallics, 2022, 41, 20
DOI: 10.1021/acs.organomet.1c00581

Preparative‐Scale Biocatalytic Oxygenation of N‐Heterocycles with a Lyophilized Peroxygenase Catalyst
Balázs Pogrányi, Tamara Mielke, Alba Díaz‐Rodríguez, Jared Cartwright, William P. Unsworth and Gideon Grogan
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202214759

Non‐Directed C−H Arylation of Anisole Derivatives via Pd/S,O‐Ligand Catalysis
Ke‐Zuan Deng, Verena Sukowski and M. Ángeles Fernández‐Ibáñez
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202400689

Research Progress of C—H Bond Asymmetric Hydroxylation
Ye Wu, Chunxia Chen and Jinsong Peng
Chinese Journal of Organic Chemistry, 2025, 45, 2726
DOI: 10.6023/cjoc202412014

Unlocking C–H Functionalization at Room Temperature via a Light-Mediated Protodemetalation Reaction
Claire Empel, Sripati Jana, Adithyaraj Koodan and Rene M. Koenigs
ACS Catal., 2022, 12, 8229
DOI: 10.1021/acscatal.2c01267

Substrate‐Rhodium Cooperativity in Photoinducedortho‐Alkynylation of Arenes
Argha Saha, Animesh Ghosh, Srimanta Guin, Sanjib Panda, Dibya Kanti Mal, Abhirup Majumdar, Munetaka Akita and Debabrata Maiti
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202210492

Diverse Approaches for Enantioselective C−H Functionalization Reactions Using Group 9 CpxMIII Catalysts
Tatsuhiko Yoshino, Shun Satake and Shigeki Matsunaga
Chemistry A European J, 2020, 26, 7346
DOI: 10.1002/chem.201905417

Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions
William D. G. Brittain and Steven L. Cobb
J. Org. Chem., 2020, 85, 6862
DOI: 10.1021/acs.joc.9b03322

Metal‐Free Electrochemical C─H Chlorination of Terminal Alkanes
Qingxu Wang, Pengkai Fang, Jianyou Zhao, Xianting Huang, Xiaoqian Shen, Fan Wang and Zhong‐Quan Liu
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202504478

C3‐Functionalized Chromones Synthesis by Tandem C−H Elaboration and Chromone Annulation of Enaminones
Leiqing Fu and Jie‐Ping Wan
Asian J Org Chem, 2019, 8, 767
DOI: 10.1002/ajoc.201900196

Cyclization by C(sp3)–H Arylation with a Transient Directing Group for the Diastereoselective Preparation of Indanes
Philip A. Provencher, Katherine L. Bay, John F. Hoskin, K. N. Houk, Jin-Quan Yu and Erik J. Sorensen
ACS Catal., 2021, 11, 3115
DOI: 10.1021/acscatal.0c05081

Harnessing the Power of C–H Functionalization Chemistry to Accelerate Drug Discovery
Bing Li, Sriram Tyagarajan, Kevin D. Dykstra, Tim Cernak, Petr Vachal and Shane W. Krska
Synlett, 2024, 35, 862
DOI: 10.1055/a-2245-6202

Carbene insertion into acyl C-H bonds: Rh(III)-catalyzed cross-coupling of 2-aminobenzaldehydes with conjugated enynones
Yifan Ping, Taiwei Chang and Jianbo Wang
Tetrahedron, 2021, 92, 132274
DOI: 10.1016/j.tet.2021.132274

Applications of Cobalt‐Catalyzed Reactions in the Total Synthesis of Natural Products
Tayebeh Momeni, Vahideh Zadsirjan, Mohammad Hadi Meshkatalsadat and Mohammadali Pourmohammadi‐Mahunaki
ChemistrySelect, 2022, 7
DOI: 10.1002/slct.202202816

Sustainable Ruthenium(II)-Catalyzed C–H Activations in and on H2O
Nikolaos Kaplaneris, Marcelo Vilches-Herrera, Jun Wu and Lutz Ackermann
ACS Sustainable Chem. Eng., 2022, 10, 6871
DOI: 10.1021/acssuschemeng.2c00873

Selective C(sp3)−H Functionalization of Alkyl Esters with N‐/S‐/O‐Nucleophiles Using Perfluoroalkyl Iodide as Oxidant
Shi‐Wen Zhao, Song‐Zhou Cai, Mao‐Lin Wang, Weidong Rao, Haiyan Xu, Lei Zhang, Xue‐Qiang Chu and Zhi‐Liang Shen
Adv Synth Catal, 2020, 362, 3388
DOI: 10.1002/adsc.202000199

Transition Metal‐Catalyzed Enantioselective C−H Functionalization via Chiral Transient Directing Group Strategies
Gang Liao, Tao Zhang, Zhi‐Keng Lin and Bing‐Feng Shi
Angew Chem Int Ed, 2020, 59, 19773
DOI: 10.1002/anie.202008437

Copper-catalyzed direct carbodiazenylation of cycloalkanes with aryldiazonium salts under redox neutral conditions
Fengxiang Zhu, Jiajia Luo and Xiao-Feng Wu
Journal of Catalysis, 2023, 424, 102
DOI: 10.1016/j.jcat.2023.05.015

Method Development and Syntheses Examples of Isotopically Labeled Compounds to Foster Operational Excellence in Pharma Industry
Anna Sib and Volker Derdau
Synlett, 2024, 35, 2155
DOI: 10.1055/a-2222-1667

Helicity-modulated remote C-H functionalization
Na Yang, Chengshuo Shen, Guoli Zhang, Fuwei Gan, Yongle Ding, Jeanne Crassous and Huibin Qiu
Sci. Adv., 2023, 9
DOI: 10.1126/sciadv.adg6680

Photochemical C–H Borylation in Organic Synthesis
Supriya Rej, Stephanie G. E. Amos and Arjan W. Kleij
ACS Catal., 2025, 15, 1753
DOI: 10.1021/acscatal.4c07169

Comparison of 1,2-Diarylcyclopropanecarboxylates with 1,2,2-Triarylcyclopropanecarboxylates as Chiral Ligands for Dirhodium-Catalyzed Cyclopropanation and C–H Functionalization
Benjamin Wertz, Zhi Ren, John Bacsa, Djamaladdin G. Musaev and Huw M. L. Davies
J. Org. Chem., 2020, 85, 12199
DOI: 10.1021/acs.joc.0c01276

C(sp2)–H Activation with Pyridine Dicarbene Iron Dialkyl Complexes: Hydrogen Isotope Exchange of Arenes Using Benzene-d6 as a Deuterium Source
Javier Corpas, Peter Viereck and Paul J. Chirik
ACS Catal., 2020, 10, 8640
DOI: 10.1021/acscatal.0c01714

One‐Pot Two‐Step Double Annulation of N‐Methoxybenzamides with Alkynes and Alkenes: Regioselective Construction of Isoindolo[2,1‐b]isoquinolin‐5(7H)‐ones
Praveen Kumar Naikawadi, Lingaswamy Mucherla, Rambabu Dandela, Madhavi Sambari and K. Shiva Kumar
Adv Synth Catal, 2021, 363, 3796
DOI: 10.1002/adsc.202100414

Dual-Functional Enone-Directing Group/Electrophile for Sequential C–C Bond Formation with α-Diazomalonates: A Short Synthesis of Chiral 3,4-Fused Tricyclic Indoles
Shingo Harada, Mai Yanagawa and Tetsuhiro Nemoto
ACS Catal., 2020, 10, 11971
DOI: 10.1021/acscatal.0c03940

Rh(III)‐Catalyzed Cross‐Coupling/Annulation of Two Carbene Precursors: Construction of Dihydrobenzo[c]chromen‐6‐one Scaffolds and Application in the Total Synthesis of Cannabinol
Sanjeev Kumar, Saiprasad Nunewar and Vinaykumar Kanchupalli
Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202100689

Strategic application of C–H oxidation in natural product total synthesis
Ian Bakanas, Robert F. Lusi, Stefan Wiesler, Jack Hayward Cooke and Richmond Sarpong
Nat Rev Chem, 2023, 7, 783
DOI: 10.1038/s41570-023-00534-6

Enantioselective Pd0‐Catalyzed C(sp2)–H Arylation for the Synthesis of Chiral Warped Molecules
David Savary and Olivier Baudoin
Angewandte Chemie, 2021, 133, 5196
DOI: 10.1002/ange.202013303

Recent Advances in Rhodium‐Catalyzed Electrochemical C−H Activation
Vikash Kumar, Rajaram Maayuri, Lusina Mantry and Parthasarathy Gandeepan
Chemistry — An Asian Journal, 2023, 18
DOI: 10.1002/asia.202300060

Recent Advances in Di-tert-butyl Peroxide (DTBP)-Promoted C-C Bond Formation Reactions
Ravi Varala, Kamsali Murali Mohan Achari, Mohamed Hussein and Mohammed Mujahid Alam
MROC, 2025, 22, 590
DOI: 10.2174/0118756298333423241022033447

Steering Site‐Selectivity in Transition Metal‐Catalyzed C−H Bond Functionalization: the Challenge of Benzanilides
Rafael Gramage‐Doria
Chemistry A European J, 2020, 26, 9688
DOI: 10.1002/chem.202000672

Climbing the Oxidase Phase Ladder by Using Dioxygen as the Sole Oxidant: The Case Study of Costunolide
Kyriaki Gennaiou, Antonis Kelesidis and Alexandros L. Zografos
Org. Lett., 2024, 26, 2934
DOI: 10.1021/acs.orglett.4c00406

Amine‐Free, Directing‐Group‐Free and Redox‐Neutral α‐Alkylation of Saturated Cyclic Ketones
Jia Qiao, Rui‐Nan Ci, Qi‐Chao Gan, Cheng Huang, Zan Liu, Hui‐Lan Hu, Chen Ye, Bin Chen, Chen‐Ho Tung and Li‐Zhu Wu
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202305679

Three distinct strategies lead to programmable aliphatic C−H oxidation in bicyclomycin biosynthesis
Lian Wu, Jun-Bin He, Wanqing Wei, Hai-Xue Pan, Xin Wang, Sheng Yang, Yong Liang, Gong-Li Tang and Jiahai Zhou
Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-58997-8

Relay C–H Functionalization Enables De Novo Synthesis of Pyridines and Pyridones
Qing-Peng Liu, Xiaoyu Chen, Ning Yu, Yu-Lin Li, Kui-Cheng He, Wei-Hao Zheng, Yu-Qiang Zhou, Kun Jiang, Limin Yang and Ye Wei
ACS Catal., 2023, 13, 5795
DOI: 10.1021/acscatal.3c00067

DDQ-Catalyzed Oxidative C(sp3)–H Functionalization of Aryltetralins and Subsequent Chemoselective Oxidative Demethylation to Access Dihydronaphthalenes and Dihydronaphthoquinones
Dileep Kumar, Abdus Salam, Tonish Kumar Sahu, Sujit Soumitra Sahoo and Tabrez Khan
J. Org. Chem., 2021, 86, 15096
DOI: 10.1021/acs.joc.1c01780

Enantioselective Divergent Syntheses of Diterpenoid Pyrones
Yunpeng Ji, Yaqian Liu, Weiqiang Guan, Chuning Guo, Hongli Jia, Benke Hong and Houhua Li
J. Am. Chem. Soc., 2024, 146, 9395
DOI: 10.1021/jacs.4c01788

Mechanochemical Solvent‐Free Catalytic C−H Methylation
Shengjun Ni, Matic Hribersek, Swarna K. Baddigam, Fredric J. L. Ingner, Andreas Orthaber, Paul J. Gates and Lukasz T. Pilarski
Angewandte Chemie, 2021, 133, 6734
DOI: 10.1002/ange.202010202

Pd(II)‐Catalyzed Tandem Enantioselective Methylene C(sp3)−H Alkenylation–Aza‐Wacker Cyclization to Access β‐Stereogenic γ‐Lactams
Yi Ding, Ye‐Qiang Han, Le‐Song Wu, Tao Zhou, Qi‐Jun Yao, Ya‐Lan Feng, Ya Li, Ke‐Xin Kong and Bing‐Feng Shi
Angewandte Chemie, 2020, 132, 14164
DOI: 10.1002/ange.202004504

Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C–H/C–H Coupling: Four-Step Total Synthesis of (±)-Russujaponol F
Zhe Zhuang, Alastair N. Herron, Shuang Liu and Jin-Quan Yu
J. Am. Chem. Soc., 2021, 143, 687
DOI: 10.1021/jacs.0c12484

Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C–H Amination Biocatalysts
Viktoria Steck, Joshua N. Kolev, Xinkun Ren and Rudi Fasan
J. Am. Chem. Soc., 2020, 142, 10343
DOI: 10.1021/jacs.9b12859

A Metal–Organic Framework as a Multiphoton Excitation Regulator for the Activation of Inert C(sp3)−H Bonds and Oxygen
Guanfeng Ji, Liang Zhao, Jianwei Wei, Junkai Cai, Cheng He, Zenggang Du, Wei Cai and Chunying Duan
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202114490

Robinson Annulation Applied to the Total Synthesis of Natural Products
Majid M. Heravi, Batoul Alipour, Vahideh Zadsirjan and Masoume Malmir
Asian J Org Chem, 2023, 12
DOI: 10.1002/ajoc.202200668

Site-Selective C–H Functionalization of N-Aryl and N-Heteroaryl Piperidines, Morpholines, and Piperazines Controlled by a Chiral Dirhodium Tetracarboxylate Catalyst
Korkit Korvorapun, Yannick T. Boni, Thomas C. Maier, Armin Bauer, Thomas Licher, John E. Macor, Volker Derdau and Huw M. L. Davies
ACS Catal., 2023, 13, 2359
DOI: 10.1021/acscatal.2c05283

Rh(III)‐Catalyzed Annulation of (Het)aryl Amides with α‐Allenyl‐Containing α‐Amino Acid Derivatives
Daria V. Vorobyeva, Alexandra S. Bubnova, Ivan A. Godovikov, Alexander F. Smol'yakov and Sergey N. Osipov
Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.202400476

Remote C–H Amination and Alkylation of Camphor at C8 through Hydrogen-Atom Abstraction
Goh Sennari, Hiroki Yamagishi and Richmond Sarpong
J. Am. Chem. Soc., 2024, 146, 7850
DOI: 10.1021/jacs.4c01351

Visible Light Mediated Cyclization of Ynones for the Synthesis of 3‐Alkyl N‐Fused Indoles via Csp3−H Bond Functionalization
Peidong Xu, Weiwei Han, Yufeng Zhou, Heng‐Ying Xiong, Shao‐Fei Ni and Guangwu Zhang
Adv Synth Catal, 2023, 365, 4533
DOI: 10.1002/adsc.202300970

N‐(Pyridin‐2‐yl)Amide‐Directed, Copper‐Mediated Cyanatation of Arene CH Bonds: A New Approach for the Synthesis of 3‐(Pyridin‐2‐yl)Quinazoline‐2,4(1H,3H)‐Diones
Ali Nasirpour, Zarrin Ghasemi, Seyed Abolfazl Hosseini‐Yazdi, Michal Dusek and Monika Kucerakova
Journal of Heterocyclic Chem, 2025, 62, 430
DOI: 10.1002/jhet.4953

Directing group assists in transition metal‐catalyzed site‐selective C‐H bond activation/transformations
Ming‐Jung Wu and Jean‐Ho Chu
J Chinese Chemical Soc, 2020, 67, 399
DOI: 10.1002/jccs.201900471

Nondirected C–H/C–F Coupling for the Synthesis of α-Fluoro Olefinated Arenes
Sandip Porey, Yogesh Bairagi, Srimanta Guin, Xinglong Zhang and Debabrata Maiti
ACS Catal., 2023, 13, 14000
DOI: 10.1021/acscatal.3c02975

Conformational Design Principles in Total Synthesis
Renzhi Chen, Yang Shen, Sihan Yang and Yandong Zhang
Angew Chem Int Ed, 2020, 59, 14198
DOI: 10.1002/anie.202003735

Mechanistically Guided Workflow for Relating Complex Reactive Site Topologies to Catalyst Performance in C–H Functionalization Reactions
Ryan C. Cammarota, Wenbin Liu, John Bacsa, Huw M. L. Davies and Matthew S. Sigman
J. Am. Chem. Soc., 2022, 144, 1881
DOI: 10.1021/jacs.1c12198

Insight into the Scope and Mechanism for Transmetalation of Hydrocarbyl Ligands on Complexes Relevant to C–H Activation
Natalie H. Chan, Joseph J. Gair, Michael Roy, Yehao Qiu, Duo-Sheng Wang, Landon J. Durak, Liwei Chen, Alexander S. Filatov and Jared C. Lewis
Organometallics, 2021, 40, 6
DOI: 10.1021/acs.organomet.0c00628

Aqueous Palladium‐Catalyzed Direct Arylation Polymerization of 2‐Bromothiophene Derivatives
Yu‐Jen Lin, Han‐Sheng Sun, Hau‐Ren Yang, Yu‐Ying Lai, Kai‐Yuan Hou and Yi‐Hung Liu
Macromol. Rapid Commun., 2020, 41
DOI: 10.1002/marc.202000021

Scalable Formal Synthesis of (−)-Quinocarcin
Sheng-Long Fang, Meng-Xue Jiang, Shuo Zhang, Yong-Jie Wu and Bing-Feng Shi
Org. Lett., 2019, 21, 4609
DOI: 10.1021/acs.orglett.9b01511

Acetoxylation and Halogenation of 2‐Arylbenzoxazinones via Palladium‐Catalyzed C(sp2)‐H Bond Oxidation
Huu Manh Vu, Fei‐Wu Chen and Xu‐Qin Li
ChemistrySelect, 2019, 4, 9465
DOI: 10.1002/slct.201902611

Rh(III)-Catalyzed Dual C–H Functionalization and C–O/C–N Annulations of Monoamide Fumarates
Zhi-Jian Han, Ze-Xuan Zhang, Jin-Jin Lin, Bin Ma, Lu-Xi Yang, Wei-Gao Pu, Yu-Min Li, Hao Chen and Chao-Shan Da
J. Org. Chem., 2022, 87, 15547
DOI: 10.1021/acs.joc.2c02091

[2.2]Benzoindenophane‐Based Chiral Indenyl Ligands: Design, Synthesis, and Applications in Asymmetric C−H Activation
Weicong Guo, Jijun Jiang and Jun Wang
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202400279

Direct Arylation of Azoles Enabled by Pd/Cu Dual Catalysis
Tiffany Piou, Yuriy Slutskyy, Nancy J. Kevin, Zhongxiang Sun, Dong Xiao and Jongrock Kong
Org. Lett., 2021, 23, 1996
DOI: 10.1021/acs.orglett.1c00100

Intramolecular C(sp3)–H Bond Oxygenation by Transition‐Metal Acylnitrenoids
Yuqi Tan, Shuming Chen, Zijun Zhou, Yubiao Hong, Sergei Ivlev, K. N. Houk and Eric Meggers
Angew Chem Int Ed, 2020, 59, 21706
DOI: 10.1002/anie.202009335

BF3 Mediated [1,5]‐Hydride Shift Triggered Cyclization: Thioethers Join the Game
Elvira R. Zaitseva, Alexander Yu. Smirnov, Vladimir I. Timashev, Vadim I. Malyshev, Ekaterina A. Zhigileva, Andrey A. Mikhaylov, Michael G. Medvedev, Nadezhda S. Baleeva and Mikhail S. Baranov
Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202200547

Organo-photoredox-Catalyzed Selective Mono- and Bis-C–H Alkylation of Electron-Rich (Hetero)Arenes
Shyamal Pramanik, Partha Pratim Mondal and Soumitra Maity
J. Org. Chem., 2023, 88, 15256
DOI: 10.1021/acs.joc.3c01757

Non‐Directed C−H Arylation of Anisole Derivatives via Pd/S,O‐Ligand Catalysis
Ke‐Zuan Deng, Verena Sukowski and M. Ángeles Fernández‐Ibáñez
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202400689

Recent Advances in Copper‐Catalyzed Functionalization of Unactivated C(sp3)−H Bonds
Neha Deshpande, Piyushkumar Satani, Akshay Bharodiya and Togati Naveen
Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200532

Innovative advancements in transition metal-catalyzed C(sp)-H bond activation of phthalazinone: Unlocking the gateway to diverse hybrid polyheterocyclic architectures
Swarnali Ghosh, Anindita Sarkar, Rahul Dev Mandal and Asish R. Das
Tetrahedron Letters, 2025, 163, 155618
DOI: 10.1016/j.tetlet.2025.155618

Concise Total Synthesis of (−)‐Quinocarcin Enabled by Catalytic Enantioselective Reductive 1,3‐Dipolar Cycloaddition of Secondary Amides
Kan‐Lei Ji, Shu‐Fan He, Dong‐Dong Xu, Wen‐Xin He, Jian‐Feng Zheng and Pei‐Qiang Huang
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202302832

Palladium-Catalyzed Branch-Selective Allylic C–H Amination Enabled by Nucleophile Coordination
Zhong-Sheng Nong, Pu-Sheng Wang, Qi-Lin Zhou and Liu-Zhu Gong
Org. Lett., 2024, 26, 8481
DOI: 10.1021/acs.orglett.4c02935

Metal‐Free Electrochemical C─H Chlorination of Terminal Alkanes
Qingxu Wang, Pengkai Fang, Jianyou Zhao, Xianting Huang, Xiaoqian Shen, Fan Wang and Zhong‐Quan Liu
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202504478

Recent Advances to Mediate Reductive Processes of Nitroarenes Using Single-Electron Transfer, Organomagnesium, or Organozinc Reagents
Haoran Zhu and Tom G. Driver
Synthesis, 2022, 54, 3142
DOI: 10.1055/a-1792-6579

A General Enantioselective C−H Arylation Using an Immobilized Recoverable Palladium Catalyst
Nihad Salameh, Federica Valentini, Olivier Baudoin and Luigi Vaccaro
ChemSusChem, 2023, 16
DOI: 10.1002/cssc.202300609

Mechanism of Iron‐Catalyzed C—H Alkenylation of Pivalophenone Derivatives With Unsymmetric Internal Alkynes
Stefano Santoro
Int J of Quantum Chemistry, 2024, 124
DOI: 10.1002/qua.27479

Rhodium‐Catalyzed Meta‐C−H Arylation of Arenes with Varied Linker Lengths: Bridging Catalytic Selectivity with Structural Diversity
Astam Mandal, Jyoti Prasad Biswas and Debabrata Maiti
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202419954

Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C−H Activation
Anna Tomberg, Michael Éric Muratore, Magnus Jan Johansson, Ina Terstiege, Christian Sköld and Per-Ola Norrby
iScience, 2019, 20, 373
DOI: 10.1016/j.isci.2019.09.035

Late‐Stage C−H Activation of Drug (Derivative) Molecules with Pd(ll) Catalysis
Su Yong Shim
Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202302620

Total Synthesis of (−)-Maximiscin
Kyle S. McClymont, Feng-Yuan Wang, Amin Minakar and Phil S. Baran
J. Am. Chem. Soc., 2020, 142, 8608
DOI: 10.1021/jacs.0c03202

Direct oxidative C(sp3)─H/C(sp2)─H coupling reaction using recyclable Sr‐doped LaCoO3 perovskite catalyst
Khang H. Trinh, Phuong H. Tran, Thanh T. Nguyen, Son H. Doan, Minh‐Vien Le, Tung T. Nguyen and Nam T.S. Phan
Applied Organom Chemis, 2020, 34
DOI: 10.1002/aoc.5515

Reaction Path Determination of Rhodium(I)-Catalyzed C–H Alkylation of N-8-Aminoquinolinyl Aromatic Amides with Maleimides
Attila Taborosi, Qiyuan He, Yusuke Ano, Naoto Chatani and Seiji Mori
J. Org. Chem., 2022, 87, 737
DOI: 10.1021/acs.joc.1c02737

Advances in Carbon‐Carbon Bond Activation by Using Photocatalysts: A Mini Review
Thuy Thanh Pham
ChemistrySelect, 2022, 7
DOI: 10.1002/slct.202202679

Multifaceted Hidden Catalysis Revealed by Mechanistic Analysis of FeBr3‐Catalysed Arene Borylation
Luke Britton, Andrew D. Bage, Sarah L. McOnie and Stephen P. Thomas
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202423929

Synthesis of Substituted 1‐Hydroxy‐2‐Naphthaldehydes by Rhodium‐Catalyzed C−H Bond Activation and Vinylene Transfer of Enaminones with Vinylene Carbonate
Min Liu, Kelu Yan, Jiangwei Wen, Weihua Liu, Mingyu Wang, Lina Wang and Xiu Wang
Adv Synth Catal, 2022, 364, 512
DOI: 10.1002/adsc.202101181

Water‐Promoted Michael Addition Reaction of Sulfonyl Hydrazides and α, β‐Unsaturated Propionic Acids to 3‐Sulfone Propionic Acids
Zhiyuan Qi, Yifan Liu, Qilong Zhang, Panfeng Zhao, Lingfeng Gao, Xu Sun and Gengxiu Zheng
Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202101456

Metalated Porous Phenanthroline‐Based Polymers as Efficient Heterogeneous Catalysts for Regioselective C−H Activation of Heteroarenes
Yongquan Tang, Zhifeng Dai, Sai Wang, Fang Chen, Xiangju Meng and Feng‐Shou Xiao
Chemistry — An Asian Journal, 2021, 16, 2469
DOI: 10.1002/asia.202100695

Enantioselective Total Synthesis of Bipolarolides A and B
Yufei Liu, Ke Sun, Qi Wei, Jin Chen, Shengling Sun, Yaxin Li, Zhongkai Feng, Yingying Guo and Zhaohong Lu
J. Am. Chem. Soc., 2025, 147, 27219
DOI: 10.1021/jacs.5c09835

Copper-Catalyzed Formal C(sp3)–H Insertions via 1,5-Diyne Cyclization Triggered by a 1,6-Hydride Shift
Tao Cai, Jian-Xing Gong, Rui Chen, Qian Wang, Chong-Yang Shi, Ming-Yu Teng, Xin-Qi Zhu and Long-Wu Ye
Org. Lett., 2025, 27, 7558
DOI: 10.1021/acs.orglett.5c02052

Palladium‐Catalyzed 2‐(Neopentylsulfinyl)aniline Directed C–H Acetoxylation and Alkenylation of Arylacetamides
Maryia V. Barysevich, Marharyta V. Laktsevich‐Iskryk, Anastasiya V. Krech, Vladimir N. Zhabinskii, Vladimir A. Khripach and Alaksiej L. Hurski
Eur J Org Chem, 2020, 2020, 937
DOI: 10.1002/ejoc.201901646

Ru3(CO)12‐Catalyzed Modular Assembly of Hemilabile Ligands by C−H Activation of Phosphines with Isocyanates
Lin Lin, Xue‐jun Zhang, Xinyu Xu, Yue Zhao and Zhuangzhi Shi
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202214584

Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
Mégane Valero, Anurag Mishra, Jennifer Blass, Remo Weck and Volker Derdau
ChemistryOpen, 2019, 8, 1183
DOI: 10.1002/open.201900204

Selective functionalization of benzylic C(sp3)–H bonds to synthesize complex molecules
Yu Zhang, Tong Zhang and Shoubhik Das
Chem, 2022, 8, 3175
DOI: 10.1016/j.chempr.2022.10.005

Pd-catalyzed methylene γ-C(sp3)—H alkenylation of N-picolinoylcycloalkylamines with alkenyl iodides promoted by 2-tert-butyl-1,4-benzoquinone
Atsushi Seki and Yoshiaki Takahashi
Tetrahedron Letters, 2021, 74, 153130
DOI: 10.1016/j.tetlet.2021.153130

Propargyl Alcohols as Bifunctional Reagents for Divergent Annulations of Biphenylamines via Dual C−H Functionalization/Dual Oxidative Cyclization
Dattatri, Maneesh Kumar Reddy Singam, Suresh Vavilapalli, Jagadeesh Babu Nanubolu and Maddi Sridhar Reddy
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202215825

Key Selectivity Controlling Elements in Rhodium-Catalyzed C–H Functionalization with Donor/Acceptor Carbenes
Zhi Ren, Djamaladdin G. Musaev and Huw M. L. Davies
ACS Catal., 2022, 12, 13446
DOI: 10.1021/acscatal.2c04490

A Metal–Organic Framework as a Multiphoton Excitation Regulator for the Activation of Inert C(sp3)−H Bonds and Oxygen
Guanfeng Ji, Liang Zhao, Jianwei Wei, Junkai Cai, Cheng He, Zenggang Du, Wei Cai and Chunying Duan
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202114490

Electrochemical Benzylic C─H Sulfation beyond the O‐Sulfonation Limitation
Wei Sheng, Huanhuan Peng, Ben Gao, Chunlan Song and Jiakun Li
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202507048

Recent advances in decarboxylative C-C bond formation using direct or in situ generated alkenyl acids
Pavneet Kaur, Vinod Kumar and Rakesh Kumar
Catalysis Reviews, 2020, 62, 118
DOI: 10.1080/01614940.2019.1700736

Palladium‐Catalyzed Novel C(formyl)‐C(aryl)/C(aryl)‐N(amine) Coupling Sequence Between 2‐(Methylamino)nicotinaldehyde and 3‐Bromo‐2‐chlorothiophene: An Efficient Construction of 4‐Pyridone Fused Hybrid Scaffolds
Mayur I. Morja, Prakashsingh M. Chauhan and Kishor H. Chikhalia
ChemistrySelect, 2021, 6, 5014
DOI: 10.1002/slct.202100790

Hemilabile Benzyl Ether Enables γ-C(sp3)–H Carbonylation and Olefination of Alcohols
Keita Tanaka, William R. Ewing and Jin-Quan Yu
J. Am. Chem. Soc., 2019, 141, 15494
DOI: 10.1021/jacs.9b08238

Donor–Acceptor–Acceptor 1,3-Bisdiazo Compounds: An Exploration of Synthesis and Stepwise Reactivity
Dylan J. Abrams, Huw M. L. Davies and Erik J. Sorensen
Org. Lett., 2020, 22, 1791
DOI: 10.1021/acs.orglett.0c00103

A Divergent Strategy for Site‐Selective Radical Disulfuration of Carboxylic Acids with Trisulfide‐1,1‐Dioxides
Zijun Wu and Derek A. Pratt
Angewandte Chemie, 2021, 133, 15726
DOI: 10.1002/ange.202104595

Selective Benzylic CH‐Borylations by Tandem Cobalt Catalysis
Pradip Ghosh, Roland Schoch, Matthias Bauer and Axel Jacobi von Wangelin
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202110821

Light-Driven C(sp3)–C(sp3) Bond Functionalizations Enabled by the PCET Activation of Alcohol O–H Bonds
Danny Q. Thach and Robert R. Knowles
Acc. Chem. Res., 2025, 58, 2061
DOI: 10.1021/acs.accounts.5c00246

Photoredox-Catalyzed C–H Functionalization Reactions
Natalie Holmberg-Douglas and David A. Nicewicz
Chem. Rev., 2022, 122, 1925
DOI: 10.1021/acs.chemrev.1c00311

A Cheap and Efficient Oxidant (n-Bu)4NNO3-Enabled C(sp2)– and C(sp3)–H Olefination at Room Temperature
Cheng-Hao Gu, Zhen Zhang, Shuo-Jie Shen, Hua-Jin Xu and Yi Hu
Org. Lett., 2023, 25, 2622
DOI: 10.1021/acs.orglett.3c00621

Development of Chiral Ligands for the Transition‐Metal‐Catalyzed Enantioselective Silylation and Borylation of C−H Bonds
Bo Su and John F. Hartwig
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202113343

Rh(III)-catalyzed C(sp2) H arylation and esterification cascade reaction of aryl acids with organic boronates
Qing-Peng He, Rong Chi, Zhen-Ang Liu and Huai-Wei Wang
Tetrahedron Letters, 2025, 160, 155562
DOI: 10.1016/j.tetlet.2025.155562

CAN‐mediated Oxidative Coupling‐Reaction of Xanthenes with Enaminones
Changyuan Zhang, Yun Qiu, Jiantao Zhang, Lulu Chen, Shuting Xu, Huosheng Guo, Jian Luo and Yao Tan
Asian J Org Chem, 2021, 10, 160
DOI: 10.1002/ajoc.202000617

Direct β-C(sp3)–H Acetoxylation of Aliphatic Carboxylic Acids
Kiron K. Ghosh, Alexander Uttry, Aylin Koldemir, Mike Ong and Manuel van Gemmeren
Org. Lett., 2019, 21, 7154
DOI: 10.1021/acs.orglett.9b02741

Toolbox for Distal C–H Bond Functionalizations in Organic Molecules
Soumya Kumar Sinha, Srimanta Guin, Sudip Maiti, Jyoti Prasad Biswas, Sandip Porey and Debabrata Maiti
Chem. Rev., 2022, 122, 5682
DOI: 10.1021/acs.chemrev.1c00220

Functionalization of Piperidine Derivatives for the Site‐Selective and Stereoselective Synthesis of Positional Analogues of Methylphenidate
Wenbin Liu, Tobias Babl, Alexander Röther, Oliver Reiser and Huw M. L. Davies
Chemistry A European J, 2020, 26, 4236
DOI: 10.1002/chem.201905773

In Situ Kinetic Studies of Rh(II)-Catalyzed C–H Functionalization to Achieve High Catalyst Turnover Numbers
Bo Wei, Jack C. Sharland, Donna G. Blackmond, Djamaladdin G. Musaev and Huw M. L. Davies
ACS Catal., 2022, 12, 13400
DOI: 10.1021/acscatal.2c04115

Recent Advances in Selective C-H Bonds Functionalization through Aryl Radical- Mediated Hydrogen Atom Transfer Strategy
Linlin Xing and Yong Zhang
COC, 2023, 27, 747
DOI: 10.2174/1385272825666230727092717

New Strategies in the Efficient Total Syntheses of Polycyclic Natural Products
Weilong Liu, Benke Hong, Jin Wang and Xiaoguang Lei
Acc. Chem. Res., 2020, 53, 2569
DOI: 10.1021/acs.accounts.0c00531

Design of Chiral NHC‐Carboxylates as Potential Ligands for Pd‐Catalyzed Enantioselective C−H Activation
Nadja E. Niggli and Olivier Baudoin
Helvetica Chimica Acta, 2021, 104
DOI: 10.1002/hlca.202100015

Chiral Ligands Based on Binaphthyl Scaffolds for Pd-Catalyzed Enantioselective C–H Activation/Cycloaddition Reactions
José Manuel González, Xandro Vidal, Manuel Angel Ortuño, José Luis Mascareñas and Moisés Gulías
J. Am. Chem. Soc., 2022, 144, 21437
DOI: 10.1021/jacs.2c09479

Cp*Co(III) catalyzed annulation of N-Cbz hydrazones for the redox-neutral synthesis of isoquinolines via C–H/N–N bond activation
Dnyaneshwar D. Subhedar, Dewal S. Deshmukh and Bhalchandra M. Bhanage
Synthetic Communications, 2019, 49, 3121
DOI: 10.1080/00397911.2019.1655765

Use of Emerging C-H Functionalization Methods to Implement Strategies for the Divergent Total Syntheses of Bridged Polycyclic Natural Products
Goh Sennari and Richmond Sarpong
J. Synth. Org. Chem. Jpn., 2023, 81, 1028
DOI: 10.5059/yukigoseikyokaishi.81.1028

Cobalt-Catalyzed Enantioselective C–H Annulation with Alkenes
Dandan Yang, Xian Zhang, Xinghua Wang, Xiao-Ju Si, Jingtao Wang, Donghui Wei, Mao-Ping Song and Jun-Long Niu
ACS Catal., 2023, 13, 4250
DOI: 10.1021/acscatal.2c06355

Selective Oxidations in the Synthesis of Complex Natural ent-Kauranes and ent-Beyeranes
Victor C. S. Santana, Eduardo C. S. Rocha, Julian C. S. Pavan, Vladimir C. G. Heleno and Emilio C. de Lucca
J. Org. Chem., 2022, 87, 10462
DOI: 10.1021/acs.joc.2c01051

Co(III) Intermediates in Cobalt-Catalyzed, Bidentate Chelation Assisted C(sp2)-H Functionalizations
Aleksandrs Cizikovs and Liene Grigorjeva
Inorganics, 2023, 11, 194
DOI: 10.3390/inorganics11050194

Rearrangements of the Chrysanthenol Core: Application to a Formal Synthesis of Xishacorene B
Kerry E. Jones, Bohyun Park, Nicolle A. Doering, Mu-Hyun Baik and Richmond Sarpong
J. Am. Chem. Soc., 2021, 143, 20482
DOI: 10.1021/jacs.1c10804

Studies towards the Enantioselective Synthesis of Cryptowolinol via Pd0-Catalyzed C(sp3)–H Arylation/Parallel Kinetic Resolution
Takeru Miyakoshi, Domenic Kronenberg, Sota Tamaki, Rafael Lombardi and Olivier Baudoin
Org. Lett., 2024, 26, 2923
DOI: 10.1021/acs.orglett.4c00386

Concise Total Synthesis of (−)‐Quinocarcin Enabled by Catalytic Enantioselective Reductive 1,3‐Dipolar Cycloaddition of Secondary Amides
Kan‐Lei Ji, Shu‐Fan He, Dong‐Dong Xu, Wen‐Xin He, Jian‐Feng Zheng and Pei‐Qiang Huang
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202302832

Porous Organic Phenanthroline‐Based Polymer as an Efficient Transition‐Metal‐Free Heterogeneous Catalyst for Direct Aromatic C−H Activation
Yongquan Tang, Fang Chen, Sai Wang, Qi Sun, Xiangju Meng and Feng‐Shou Xiao
Chemistry A European J, 2021, 27, 8684
DOI: 10.1002/chem.202100288

Hydrogen-Evolution Allylic C(sp3)–H Alkylation with Protic C(sp3)–H Bonds via Triplet Synergistic Brønsted Base/Cobalt/Photoredox Catalysis
Meng-Yuan Dong, Chun-Yu Han, Dong-Sheng Li, Yang Hong, Fang Liu and Hong-Ping Deng
ACS Catal., 2022, 12, 9533
DOI: 10.1021/acscatal.2c02885

Rose‐Bengal‐Photocatalyzed Cross‐Dehydrogenative Coupling Reactions under Visible Light
Divyani P. Patel and Satish Kumar Singh
Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202301185

Recent Advances in C–H Functionalisation through Indirect Hydrogen Atom Transfer
Filip S. Meger and John A. Murphy
Molecules, 2023, 28, 6127
DOI: 10.3390/molecules28166127

Enzyme Kits to Facilitate the Integration of Biocatalysis into Organic Chemistry – First Aid for Synthetic Chemists
Nico D. Fessner, Christoffel P. S. Badenhorst and Uwe T. Bornscheuer
ChemCatChem, 2022, 14
DOI: 10.1002/cctc.202200156

Intermolecular Radical C(sp3)−H Amination under Iodine Catalysis
Alexandra E. Bosnidou and Kilian Muñiz
Angew Chem Int Ed, 2019, 58, 7485
DOI: 10.1002/anie.201901673

Free‐Radical‐Promoted Alkenylation of C(sp3)−H Bond in Chloroalkane with Cinnamic Acid and β‐Nitrostyrene
Minzhi Sun, Zhengbao Xu, Wenjie Li, Le Yang, Huichao You, Dan Yu, Fang Fang, Yaxin Wang and Zhong‐Quan Liu
Adv Synth Catal, 2020, 362, 2195
DOI: 10.1002/adsc.202000215

Mechanochemically Induced Cross Dehydrogenative Coupling Reactions under Ball Milling
Ilya N. Egorov, Anindita Mukherjee, Sougata Santra, Dmitry S. Kopchuk, Igor S. Kovalev, Yuanli Liu, Grigory V. Zyryanov, Adinath Majee, Oleg N. Chupakhin and Brindaban C. Ranu
Adv Synth Catal, 2022, 364, 2462
DOI: 10.1002/adsc.202200296

Mechanism and Origin of Remote Stereocontrol in the Organocatalytic Enantioselective Formal C(sp2)–H Alkylation Using Nitroalkanes as Alkylating Agents
Sharath Chandra Mallojjala, Rahul Sarkar, Rachael W. Karugu, Madhu Sudan Manna, Sayan Ray, Santanu Mukherjee and Jennifer S. Hirschi
J. Am. Chem. Soc., 2022, 144, 17399
DOI: 10.1021/jacs.2c02941

Asymmetric total synthesis of benzenoid cephalotane-type diterpenoids through a cascade C(sp2) & C(sp3)–H activation
Xiangxin Li, Zhaoxu Lu, Shaocong Liu, Mengyao Sun, Shengfu Duan and Zhixiang Xie
Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-59816-w