Issue 7, 2024

Applications of peptide-based nanomaterials in targeting cancer therapy

Abstract

To meet the demand for precision medicine, researchers are committed to developing novel strategies to reduce systemic toxicity and side effects in cancer treatment. Targeting peptides are widely applied due to their affinity and specificity, and their ability to be high-throughput screened, chemically synthesized and modified. More importantly, peptides can form ordered self-assembled structures through non-covalent supramolecular interactions, which can form nanostructures with different morphologies and functions, playing crucial roles in targeted diagnosis and treatment. Among them, in targeted immunotherapy, utilizing targeting peptides to block the binding between immune checkpoints and ligands, thereby activating the immune system to eliminate cancer cells, is an advanced therapeutic strategy. In this mini-review, we summarize the screening, self-assembly, and biomedical applications of targeting peptide-based nanomaterials. Furthermore, this mini-review summarizes the potential and optimization strategies of targeting peptides.

Graphical abstract: Applications of peptide-based nanomaterials in targeting cancer therapy

Article information

Article type
Review Article
Submitted
12 Des 2023
Accepted
03 Feb 2024
First published
07 Feb 2024

Biomater. Sci., 2024,12, 1630-1642

Applications of peptide-based nanomaterials in targeting cancer therapy

B. Sun, L. Zhang, M. Li, X. Wang and W. Wang, Biomater. Sci., 2024, 12, 1630 DOI: 10.1039/D3BM02026F

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