Issue 12, 2020

Vibrational optical activity for structural characterization of natural products

Abstract

Covering: 2015 to up to 2019

This review presents the recent progress towards elucidating the structures of chiral natural products and applications using vibrational optical activity (VOA) spectroscopy. Vibrational circular dichroism (VCD) and vibrational Raman optical activity (VROA) are two separate branches of VOA spectroscopy, providing independent and complementary structural information. While determining the absolute configuration (AC) of a given natural product is the primary goal, the determination or assessment of major conformations associated with each diastereomer is also a significant part of this enquiry. The latest developments in experimental and computational aspects of VOA spectroscopies and their applications for inferring the AC and predominant conformations of natural products are summarized. The prospects and limitations in the application of VOA spectroscopy to new natural products are summarized.

Graphical abstract: Vibrational optical activity for structural characterization of natural products

Article information

Article type
Review Article
Submitted
14 Mei 2020
First published
01 Jul 2020

Nat. Prod. Rep., 2020,37, 1661-1699

Author version available

Vibrational optical activity for structural characterization of natural products

P. L. Polavarapu and E. Santoro, Nat. Prod. Rep., 2020, 37, 1661 DOI: 10.1039/D0NP00025F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements