Issue 24, 2019

A multifunctional near-infrared laser-triggered drug delivery system using folic acid conjugated chitosan oligosaccharide encapsulated gold nanorods for targeted chemo-photothermal therapy

Abstract

The development of a new generation of multifunctional nanomaterials as a drug delivery system for chemo-photothermal therapy is of great necessity. In this study, we first prepared folic acid-conjugated and doxorubicin-loaded chitosan oligosaccharide encapsulated gold nanorods (FA–COS–TGA–GNRs–DOX) as a new photothermal agent for the delivery of drugs and heat to tumor areas. FA–COS–TGA–GNRs–DOX nanomaterials combine the advantages of COS, GNRs, FA, TGA, and DOX and have excellent biocompatibility, strong absorbance in the near-infrared (NIR) region, photostability, photothermal conversion efficiency, high targeting efficiency, fast drug release under laser irradiation, and tumor cell killing efficiency. FA–COS–TGA–GNRs–DOX exhibited significantly greater cell killing after laser irradiation. The intracellular uptake behavior of the targeted FA–COS–TGA–GNRs–DOX was confirmed by flow cytometry, two-photon fluorescence microscopy (TPFM), and confocal laser scanning microscopy (CLSM). More interestingly, the tumors in the presence of FA–COS–TGA–GNRs–DOX under laser irradiation were efficiently ablated and did not recur, showing an outstanding combined therapy of tumors. The combination of photothermal therapy (PTT) and photoacoustic imaging (PAI) could accurately locate and fully destroy tumor tissues after the intravenous injection of FA–COS–TGA–GNRs–DOX. Hence, this work offers a new avenue to develop a novel class of multifunctional nanomaterials as a drug delivery system for cancer therapy.

Graphical abstract: A multifunctional near-infrared laser-triggered drug delivery system using folic acid conjugated chitosan oligosaccharide encapsulated gold nanorods for targeted chemo-photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
25 Okt 2018
Accepted
22 Nov 2018
First published
29 Nov 2018

J. Mater. Chem. B, 2019,7, 3811-3825

A multifunctional near-infrared laser-triggered drug delivery system using folic acid conjugated chitosan oligosaccharide encapsulated gold nanorods for targeted chemo-photothermal therapy

P. Manivasagan, S. W. Jun, V. T. Nguyen, N. T. P. Truong, G. Hoang, S. Mondal, M. Santha Moorthy, H. Kim, T. T. Vy Phan, V. H. M. Doan, C. Kim and J. Oh, J. Mater. Chem. B, 2019, 7, 3811 DOI: 10.1039/C8TB02823K

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