Issue 1, 2017

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Graphical abstract: Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

Supplementary files

Article information

Article type
Communication
Submitted
27 Sep 2016
Accepted
23 Nov 2016
First published
06 Des 2016

Biomater. Sci., 2017,5, 38-40

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

X. Luo, W. Wang, J. R. Dorkin, O. Veiseh, P. H. Chang, I. Abutbul-Ionita, D. Danino, R. Langer, D. G. Anderson and Y. Dong, Biomater. Sci., 2017, 5, 38 DOI: 10.1039/C6BM00683C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements