Issue 22, 2017

MoS2/Pt nanocomposite-functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cells

Abstract

This work describes the adaptive use of a conventional stainless steel acupuncture needle as the electrode substrate for construction of a molybdenum disulfide (MoS2) and platinum nanoparticles (PtNPs) layer-modified microneedle sensor for real-time monitoring of hydrogen peroxide (H2O2) release from living cells. To construct the nanocomposite-functionalized microneedle, the needle surface was first coated with a gold film by ion sputtering to enhance the conductivity. Subsequently, an electrochemical deposition method was successfully employed to deposit MoS2 nanosheet and Pt nanoparticles on the needle tip as the sensing interface. Electrochemical study demonstrated that the MoS2/PtNPs nanocomposite-modified needle exhibited excellent catalytic performance and low over-potential toward the reduction of H2O2. Not only did the microneedle achieve a wide linear range from 1 to 100 μmol L−1 with a limit of detection down to 0.686 μmol L−1, but it also realized the highly specific detection of H2O2. Owing to these remarkable analytical advantages, the prepared microneedle was applied to determine H2O2 release from living cells with satisfactory results. The MoS2/PtNPs nanocomposite-functionalized microneedle sensor is simple and affordable, and can serve as a promising electrochemical nonenzymatic sensing platform. Moreover, this superfine needle sensor shows great potential for real-time monitoring of reactive oxygen species in vivo with minimal damage.

Graphical abstract: MoS2/Pt nanocomposite-functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cells

Supplementary files

Article information

Article type
Paper
Submitted
01 Sep 2017
Accepted
12 Okt 2017
First published
13 Okt 2017

Analyst, 2017,142, 4322-4329

MoS2/Pt nanocomposite-functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cells

J. Zhou, L. Tang, F. Yang, F. Liang, H. Wang, Y. Li and G. Zhang, Analyst, 2017, 142, 4322 DOI: 10.1039/C7AN01446E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements