Issue 17, 2016

A hydrothermal reaction of an aqueous solution of BSA yields highly fluorescent N doped C-dots used for imaging of live mammalian cells

Abstract

In the current study, we present a new and facile synthesis of N doped C-dots (N@C-dots) by hydrothermally reacting an aqueous solution of Bovine Serum Albumin (BSA). The as-prepared quantum dots (QDs) exhibited high quantum yield (44%), high photostability, colloidal stability, and high functionalization efficiency. In addition to their low cost, the N@C-dots have demonstrated a non-toxic and long-lasting effect when applied for imaging human cells (human osteosarcoma U2OS cells). Importantly, with high physiological stability, excellent biocompatibility, and homogenous distribution, the N@C-dot suspension was exploited for high quality cell imaging and to model the biological effects at the nuclear level. Moreover, the water-soluble N@C-dots are nontoxic to the selected cell line in our preliminary evaluation.

Graphical abstract: A hydrothermal reaction of an aqueous solution of BSA yields highly fluorescent N doped C-dots used for imaging of live mammalian cells

Supplementary files

Article information

Article type
Paper
Submitted
28 Feb 2016
Accepted
24 Mac 2016
First published
24 Mac 2016

J. Mater. Chem. B, 2016,4, 2913-2920

A hydrothermal reaction of an aqueous solution of BSA yields highly fluorescent N doped C-dots used for imaging of live mammalian cells

V. B. Kumar, J. Sheinberger, Z. Porat, Y. Shav-Tal and A. Gedanken, J. Mater. Chem. B, 2016, 4, 2913 DOI: 10.1039/C6TB00519E

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