Issue 7, 2016

Distance-based microfluidic quantitative detection methods for point-of-care testing

Abstract

Equipment-free devices with quantitative readout are of great significance to point-of-care testing (POCT), which provides real-time readout to users and is especially important in low-resource settings. Among various equipment-free approaches, distance-based visual quantitative detection methods rely on reading the visual signal length for corresponding target concentrations, thus eliminating the need for sophisticated instruments. The distance-based methods are low-cost, user-friendly and can be integrated into portable analytical devices. Moreover, such methods enable quantitative detection of various targets by the naked eye. In this review, we first introduce the concept and history of distance-based visual quantitative detection methods. Then, we summarize the main methods for translation of molecular signals to distance-based readout and discuss different microfluidic platforms (glass, PDMS, paper and thread) in terms of applications in biomedical diagnostics, food safety monitoring, and environmental analysis. Finally, the potential and future perspectives are discussed.

Graphical abstract: Distance-based microfluidic quantitative detection methods for point-of-care testing

Article information

Article type
Critical Review
Submitted
23 Des 2015
Accepted
18 Feb 2016
First published
18 Feb 2016

Lab Chip, 2016,16, 1139-1151

Distance-based microfluidic quantitative detection methods for point-of-care testing

T. Tian, J. Li, Y. Song, L. Zhou, Z. Zhu and C. J. Yang, Lab Chip, 2016, 16, 1139 DOI: 10.1039/C5LC01562F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements