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RSC Sustainability

Sustainable synthesis of sulfonamides via oxidative chlorination in alternative solvents: a general, mild, and eco-friendly strategy

Abelardo Gutiérrez Hernández,a   Francisco J. Sierra-Molero, ORCID logo b   Alejandro Baeza Carratalá, ORCID logo b   Francisco Méndez, ORCID logo c   Claudia Araceli Contreras-Celedón ORCID logo *a  and  Diego A. Alonso ORCID logo *b  

* Corresponding authors

a Departamento de Síntesis Orgánica, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mexico
E-mail: claudia.contreras@umich.mx

b Department of Organic Chemistry and Organic Synthesis Institute (ISO), Alicante University, Apdo. 99, 03080 Alicante, Spain
E-mail: diego.alonso@ua.es, alex.baeza@ua.es

c Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México 09340, Mexico

Abstract

A general, mild, and environmentally friendly method for synthesizing sulfonamides in sustainable solvents was developed. Sodium dichloroisocyanurate dihydrate (NaDCC·2H2O) served as an efficient oxidant for converting thiols to sulfonyl chlorides, which then reacted in situ with various amines to afford sulfonamides in good to excellent yields in water, EtOH, glycerol and the DES ChCl/glycerol: 1/2. The process features simple conditions and a solvent-free workup involving only filtration, highlighting its potential as a green and practical approach to sulfonamide synthesis.

Graphical abstract: Sustainable synthesis of sulfonamides via oxidative chlorination in alternative solvents: a general, mild, and eco-friendly strategy

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Article information

DOI
https://doi.org/10.1039/D5SU00405E
Article type
Paper
Submitted
04 Jun 2025
Accepted
05 Aug 2025
First published
06 Aug 2025
This article is Open Access
Creative Commons BY-NC license

RSC Sustainability, 2025, Advance Article

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Sustainable synthesis of sulfonamides via oxidative chlorination in alternative solvents: a general, mild, and eco-friendly strategy

A. G. Hernández, F. J. Sierra-Molero, A. B. Carratalá, F. Méndez, C. A. Contreras-Celedón and D. A. Alonso, RSC Sustainability, 2025, Advance Article , DOI: 10.1039/D5SU00405E

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