Enabling technology for accelerated discovery of supramolecular materials

Abstract

Organic supramolecular materials, defined by their discrete, modular nature, promise to deliver flexible solutions to pressing challenges, including separations, storage, sensing, and catalysis. The absence of strong metallic or covalent bonding within their solid-state structures enables fine-tuning and post-synthetic processing to tailor properties towards specific applications. However, their production suffers from poor reproducibility, scalability, and sustainability; as a result, translation of these materials from the lab to real-world situations is rare. In this perspective, we discuss how the field stands to benefit from the emergence of ‘enabling technologies’, such as high-throughput screening (HTS), automation, and flow chemistry. We summarise recent advances and consider the opportunities these technologies present for the accelerated discovery, optimisation, and translation of supramolecular materials.

Graphical abstract: Enabling technology for accelerated discovery of supramolecular materials

Article information

Article type
Perspective
Submitted
30 May 2025
Accepted
06 Oct 2025
First published
08 Oct 2025
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2025, Advance Article

Enabling technology for accelerated discovery of supramolecular materials

C. E. Shields, A. M. Scholes and A. G. Slater, Chem. Sci., 2025, Advance Article , DOI: 10.1039/D5SC03960F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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