Beyond serendipity: uncovering novel ratiometric urea·24DHBA cocrystals through mechanochemistry and MicroED

Abstract

Mechanochemical synthesis of urea cocrystals with 2,4-dihydroxybenzoic acid (24DHBA) reveals two new stoichiometric forms: (urea)2·(24DHBA) and (urea)2·(24DHBA)2, not accessible via solution methods. The known (urea)0.5·(24DHBA) form remains the most stable. These findings provide critical insights into stoichiometric tuning of agro-cocrystals and pave the way for their practical application in sustainable agriculture.

Graphical abstract: Beyond serendipity: uncovering novel ratiometric urea·24DHBA cocrystals through mechanochemistry and MicroED

Supplementary files

Article information

Article type
Communication
Submitted
27 Jun 2025
Accepted
26 Aug 2025
First published
03 Sep 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025, Advance Article

Beyond serendipity: uncovering novel ratiometric urea·24DHBA cocrystals through mechanochemistry and MicroED

A. Bonia, D. Gogoi, N. Kalita, T. Nakane, A. Kawamoto, K. Althubeiti, T. Sasaki, G. Kurisu and R. Thakuria, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03628C

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