Issue 24, 2024

Near-infrared AIEgens for sulfatase imaging in breast cancer in vivo

Abstract

Aggregation-induced emission luminogens (AIEgens) enable highly sensitive and in situ visualization of sulfatase to benefit the early diagnosis of breast cancer (BC), but current sulfatase AIEgens always emit visible light (<650 nm). Herein, a near-infrared (NIR) AIEgen QMT-SFA is developed for sulfatase imaging in vivo. Hydrophilic QMT-SFA is cleaved by sulfatase to yield hydrophobic QMT-OH, which subsequently aggregates into nanoparticles to turn the AIE fluorescence “on”, enabling sensitive sulfatase imaging in 4T1 cells and mouse models.

Graphical abstract: Near-infrared AIEgens for sulfatase imaging in breast cancer in vivo

Supplementary files

Article information

Article type
Communication
Submitted
25 Mac 2024
Accepted
28 Mei 2024
First published
30 Mei 2024

Nanoscale, 2024,16, 11538-11541

Near-infrared AIEgens for sulfatase imaging in breast cancer in vivo

L. Xu, Y. Deng, H. Gao, Y. Yao, X. Liu, W. Zhan, G. Liang and X. Sun, Nanoscale, 2024, 16, 11538 DOI: 10.1039/D4NR01314J

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