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We present a water-soluble fluorescence/MR dual-modality probe NBD[Gd] for H2S detection. It showed 88.4% of fluorescence quenching and a 36% reduction in r1 upon exposure to H2S. It is readily uptaken by cells to sense the endogenous H2S. Besides providing a bimodal H2S imaging probe, our study also confirms the high H2S level in CT26 cells and its functional consequence in promoting cell growth.

Graphical abstract: A water-soluble Gd(iii)-based fluorescence/T1-MR dual-modality probe for H2S sensing

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