Issue 16, 2024

Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Abstract

With the increasing research and deepening understanding of the glioblastoma (GBM) tumour microenvironment (TME), novel and more effective therapeutic strategies have been proposed. The GBM TME involves intricate interactions between tumour and non-tumour cells, promoting tumour progression. Key therapeutic goals for GBM treatment include improving the immunosuppressive microenvironment, enhancing the cytotoxicity of immune cells against tumours, and inhibiting tumour growth and proliferation. Consequently, remodeling the GBM TME using nanotechnology has emerged as a promising approach. Nanoparticle-based drug delivery enables targeted delivery, thereby improving treatment specificity, facilitating combination therapies, and optimizing drug metabolism. This review provides an overview of the GBM TME and discusses the methods of remodeling the GBM TME using nanotechnology. Specifically, it explores the application of nanotechnology in ameliorating immune cell immunosuppression, inducing immunogenic cell death, stimulating, and recruiting immune cells, regulating tumour metabolism, and modulating the crosstalk between tumours and other cells.

Graphical abstract: Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Article information

Article type
Review Article
Submitted
14 Mei 2024
Accepted
08 Jul 2024
First published
09 Jul 2024

Biomater. Sci., 2024,12, 4045-4064

Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Y. Mu, Z. Zhang, H. Zhou, L. Ma and D. Wang, Biomater. Sci., 2024, 12, 4045 DOI: 10.1039/D4BM00665H

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